Patents by Inventor Charles Lespagnol
Charles Lespagnol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5240949Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,R.sub.2 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted thienyl, furyl, pyrrolyl or pyridinyl group,X represents a hydrogen atom,Y represents a hydroxyl group,or else X and Y together represent an oxygen atom, their enantiomers, diastereoisomers and epimers. Medicaments.Type: GrantFiled: March 27, 1992Date of Patent: August 31, 1993Assignee: Adir et CompagnieInventors: Daniel Lesieur, Charles Lespagnol, Said Yous
-
Patent number: 5182278Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl optionally substituted with a hydroxyl group,R.sub.2 and R.sub.3 :a- identical or different, denote a hydrogen atom, a lower alkyl, a lower alkenyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (lower alkyl)aryl,b- are such that they form, with the nitrogen which carries them, a saturated or unsaturated, mono- or bicyclic heterocyclic system containing at most 3 hetero atoms per ring, substituted or unsubstituted, with the exception of 1-arylpiperazine systems,X denotes a hydrogen atom,Y denotes a hydrogen atom or a hydroxyl,or alternatively X and Y denote an oxygen atom, provided thatR.sub.1 is then other than a methyl group,Z denotes a hydrogen atom or forms a .pi.Type: GrantFiled: July 29, 1991Date of Patent: January 26, 1993Assignee: Adir et CompagnieInventors: Daniel Lesieur, Charles Lespagnol, Jacqueline Bonnet
-
Patent number: 5166353Abstract: Compounds of general formula(I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,R.sub.2 represents a substituted or unsubstitutes alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted thienyl, furyl, pyrrolyl or pyridinyl group,X represents a hydrogen atom,Y represents a hydroxyl group,or else X and Y together represent an oxygen atom, their enantiomers, diastereoisomers and epimers. Medicaments.Type: GrantFiled: May 15, 1991Date of Patent: November 24, 1992Assignee: Adir et CompagnieInventors: Daniel Lesieur, Charles Lespagnol, Said Yous
-
Patent number: 5162350Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,R.sub.2 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted thienyl, furyl, pyrrolyl or pyridinyl group,X represents a hydrogen atom,Y represents a hydroxyl group,or else X and Y together represent an oxygen atom, their enantiomers, diastereoisomers and epimers. Medicaments.Type: GrantFiled: April 27, 1990Date of Patent: November 10, 1992Assignee: Adir et CompagnieInventors: Daniel Lesieur, Charles Lespagnol, Said Yous
-
Patent number: 5147883Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,A represents a hydrogen atom, and in this case B represents a group CO-G, G being:either a heteroaryl group selected from furan, indole, pyrrole, pyridine, quinoline, isoquinoline and benzofuran, optionally substituted with one or more lower alkyl or lower alkoxy groups or a halogen atoms,or a linear or branched lower alkyl group substituted with a carboxyl group,or a linear or branched lower alkenyl group substituted with a carboxyl group,or a phenyl or naphthyl group substituted with a carboxyl group,or alternatively A forms with B a group CO(CH.sub.2).sub.n CH(CH.sub.Type: GrantFiled: May 31, 1991Date of Patent: September 15, 1992Assignee: Adir et CompagnieInventors: Hocine Aichaioui, Daniel Lesieur, Charles Lespagnol, Michelle Devissaguet, Beatrice Guardiola
-
Patent number: 5132305Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl optionally substituted with a hydroxyl group,R.sub.2 and R.sub.3 :a--identical or different, denote a hydrogen atom, a lower alkyl, a lower alkenyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (lower alkyl)aryl,b--are such that they form, with the nitrogen which carries them, a saturated or unsaturated, mono- or bicyclic heterocyclic system containing at most 3 hetero atoms per ring, substituted or unsubstituted, with the exception of 1-arylpiperazine systems,X denotes a hydrogen atom,Y denotes a hydrogen atom or a hydroxyl,or alternatively X and Y denote an oxygen atom, provided that R.sub.1 is then other than a methyl group,Z denotes a hydrogen atom or forms a .pi. bond with Y, andT denotes a hydrogen atom or a lower alkyl, their stereoisomers and their quaternary ammonium salts, as well as their addition salts with a pharmaceutically acceptable acid.Type: GrantFiled: February 26, 1990Date of Patent: July 21, 1992Assignee: Adir et CompagnieInventors: Daniel Lesieur, Charles Lespagnol, Jacqueline Bonnet
-
Patent number: 4778792Abstract: The invention relates to products characterized by the general formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R and X have the meanings indicated in claim 1. The invention also related to pharmaceutical compositions administrable particularly orally, containing the abovesaid compounds in association with a pharmaceutically acceptable vehicle. They are useful as medicaments.Type: GrantFiled: October 20, 1986Date of Patent: October 18, 1988Assignee: Laboratories NegmaInventors: Isabelle Lesieur, Charles Lespagnol, Ziaddine Moussavi, Jean-Claude Fruchart, Jacques Sauzieres, Nicole Monfilliette
-
Patent number: 4558060Abstract: The invention relates to compounds of the formula: ##STR1## in which R represents hydrogen or a lower alkyl radical and R.sub.1 and R.sub.2 separately represent hydrogen, a lower alkyl, cycloalkyl or benzyl radical, or represent, together with the nitrogen atom to which they are bonded, a heterocyclic radical such as a morpholino, 4-(pyrimidin-2-yl)-piperazinyl or 4-phenylpiperazinyl the phenyl radical of which being optionally substituted by halogen, lower alkoxy or trifluoromethyl, having CNS activity and particularly hypnotic properties.Moreover the compounds in which R.sub.1 and R.sub.2 are hydrogen can be used in the treatment of heart failure.Type: GrantFiled: November 22, 1983Date of Patent: December 10, 1985Assignee: Riom Laboratories - Cerm S.A.Inventors: Daniel H. Caignard, Charles Lespagnol, Daniel Lesieur, Norbert Busch
-
Patent number: 4185114Abstract: Compounds of the formula ##STR1## wherein X and Y, which may be identical to or different from each other, are each hydrogen or halogen,R.sub.1 is hydrogen or straight or branched alkyl of 1 to 4 carbon atoms,R.sub.2 is hydrogen, straight or branched alkyl of 1 to 3 carbon atoms, carboxy-lower alkyl or acyl, preferably lower aliphatic carboxylic acyl,R.sub.3 is hydrogen or acyl, preferably lower aliphatic carboxylic acyl, andn is 1 or 2;non-toxic, pharmacologically acceptable acid addition salts thereof; sulfonium salts thereof; and, when R.sub.1 is hydrogen, salts thereof formed with inorganic or organic bases or basic aminoacids. The compounds as well as their various salts are useful as mucolytics.Type: GrantFiled: June 27, 1977Date of Patent: January 22, 1980Assignee: Boehringer Ingelheim GmbHInventors: Henri Baille-Barrelle, Maurice Vigneron, Charles Lespagnol