Patents by Inventor Charles Lewis
Charles Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240148980Abstract: A needle actuator assembly for a drug delivery system includes a housing, a needle having retracted and extended positions, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position to a use position where the needle is in the extended position and to a post-use position where the needle is in the retracted position, with the needle actuator having a button contact surface, and an actuator button received by the housing.Type: ApplicationFiled: January 19, 2024Publication date: May 9, 2024Inventors: Oliver Charles Gazeley, Gareth James Lewis, David Aubrey Plumptre, Malcolm Stanley Boyd
-
Publication number: 20240115721Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: ApplicationFiled: January 13, 2022Publication date: April 11, 2024Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, DAIICHI SANKYO COMPANY, LIMITEDInventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ, Hironori MATSUNAGA
-
Publication number: 20240115720Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.Type: ApplicationFiled: January 13, 2022Publication date: April 11, 2024Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, DAIICHI SANKYO COMPANY, LIMITEDInventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ, Hironori MATSUNAGA
-
Patent number: 11939086Abstract: A fuel tank comprises an interior wall, a sump, and a baffle that comprises a center fitting, a full-length containment petal, a partial-length containment petal, a dump tube. The full-length containment petal comprises a full-length side edge, extending radially outward from the center fitting. The partial-length containment petal comprises a partial-length side edge, extending radially outward from the center fitting. The dump tube is connected to the sump. The full-length side edge of the full-length containment petal is longer than the partial-length side edge of the partial-length containment petal. All of the partial-length side edge of the partial-length containment petal is attached to a linear portion of the full-length side edge of the full-length containment petal.Type: GrantFiled: August 18, 2021Date of Patent: March 26, 2024Assignee: The Boeing CompanyInventors: Jonathan David Embler, Tin Anh Luu, Morgan Ashley Lewis, John Matthew Nichols, Keith Charles Kreutztrager, Chinh Manh Cao, Jonathan Edward Toomey, Martin Edward Lozano, Alfredo Lopez
-
Publication number: 20240091452Abstract: A drug delivery system for injecting a medicament includes a housing, a container configured to receive a medicament including a stopper configured to move within the container and a closure, a needle in fluid communication with the container, a spacer configured to be engaged with the stopper, a first plunger, a first spring configured to bias the first plunger in an axial direction, second plunger disposed about the first plunger, a second spring configured to bias the second plunger in an axial direction. The first plunger is configured to move the spacer and the container relative to the housing via the first spring to establish fluid communication between the container and the patient needle, and the second plunger is configured to move the spacer and the stopper relative to the container via the second spring.Type: ApplicationFiled: November 15, 2023Publication date: March 21, 2024Inventors: Oliver Charles Gazeley, David Aubrey Plumptre, Malcolm Stanley Boyd, Gareth James Lewis, James Alexander Senior
-
Publication number: 20240097688Abstract: An example frequency converter includes a drift canceling loop with a balanced delay and a linear signal path (e.g., linear with respect to frequency scaling, amplitude modulation, and/or phase modulation). One side of the drift canceling loop includes a fixed delay, and the opposite side includes an adjustable, complementary delay. The adjustable, complementary delay facilitates precision matching of the signal delays on each side of the loop over a range of frequencies, which results in a significant improvement in noise cancelation, particularly at large offsets to the carrier, while permitting the use of a higher noise, but very fast tuning course scale oscillator. The linear signal path from the signal generator to an RF output facilitates modulation of the signal by the signal generator. A modular format is an advantageous embodiment of the invention that includes the removal of the frequency synthesizer's low phase noise reference into a separate module.Type: ApplicationFiled: April 19, 2023Publication date: March 21, 2024Applicant: Giga-tronics IncorporatedInventors: John R. Regazzi, Charles Lewis, Carios Fuentes
-
Patent number: 11883601Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system. In one embodiment, a nasal cannula includes a base portion defining a first therapeutic gas passageway, a nozzle disposed adjacent said base portion and defining a second therapeutic gas passageway, the first passageway being in gaseous communication with the second passageway and a conduit configured to facilitate sensing that has an inlet side that is independent of and axially spaced apart from an outlet side of the nozzle. The conduit inlet side can extend beyond the nozzle outlet side of the nasal cannula. Additionally, the nasal cannula has a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare and a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare.Type: GrantFiled: June 5, 2020Date of Patent: January 30, 2024Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Patent number: 11833301Abstract: A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient includes a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the respiratory gas is controlled by a microprocessor, a mixing area for mixing a first gas and a second gas in the respiratory gas flow pathway, a humidification area downstream of the mixing area and configured for humidifying respiratory gas in the respiratory gas flow pathway, and a heated delivery conduit for minimizing condensation of humidified respiratory gas.Type: GrantFiled: August 29, 2016Date of Patent: December 5, 2023Inventors: Robert M Landis, Charles A Lewis, Louis Javier Collazo
-
Patent number: 11717174Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.Type: GrantFiled: July 28, 2021Date of Patent: August 8, 2023Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Publication number: 20230240822Abstract: A toothbrush system configured to be coupled to an external suction source. The toothbrush system includes a shaft with a main body with a first end and a second end, and a bristle array and a suction port arranged at the second end. The bristle array and the suction port both extend away from the shaft so that an opening of the suction port is proximal to a distal end of the bristle array. The shaft also includes a stem arranged at the first end. The stem includes a passageway that extends through the main body to provide a fluid connection to the suction port, and is configured to be coupled to the external suction source. Also, the handle is removably coupled to the shaft and includes a drive system operably coupled to the bristle array to actuate motion of the bristle array.Type: ApplicationFiled: April 11, 2023Publication date: August 3, 2023Inventors: Virginia PRENDERGAST, Cynthia KLEIMAN, Charles LEWIS, Gary LAUTERBACH, Scott CASTANON, Dylann CERIANI, Michael WILLIAMS
-
Patent number: 11696992Abstract: A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient includes a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the respiratory gas is controlled by a microprocessor, a mixing area for mixing a first gas and a second gas in the respiratory gas flow pathway, a humidification area downstream of the mixing area and configured for humidifying respiratory gas in the respiratory gas flow pathway, and a heated delivery conduit for minimizing condensation of humidified respiratory gas.Type: GrantFiled: August 8, 2022Date of Patent: July 11, 2023Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Publication number: 20230201508Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system. In one embodiment, a nasal cannula includes a base portion defining a first therapeutic gas passageway, a nozzle disposed adjacent the base portion and defining a second therapeutic gas passageway, the first passageway being in gaseous communication with the second passageway and a conduit configured to facilitate sensing that has an inlet side that is independent of and axially spaced apart from an outlet side of the nozzle. The conduit inlet side can extend beyond the nozzle outlet side of the nasal cannula. Additionally, the nasal cannula has a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's rare and a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare.Type: ApplicationFiled: March 3, 2023Publication date: June 29, 2023Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Patent number: 11664812Abstract: An example frequency converter includes a drift canceling loop with a balanced delay and a linear signal path (e.g., linear with respect to frequency scaling, amplitude modulation, and/or phase modulation). One side of the drift canceling loop includes a fixed delay, and the opposite side includes an adjustable, complementary delay. The adjustable, complementary delay facilitates precision matching of the signal delays on each side of the loop over a range of frequencies, which results in a significant improvement in noise cancelation, particularly at large offsets to the carrier, while permitting the use of a higher noise, but very fast tuning course scale oscillator. The linear signal path from the signal generator to an RF output facilitates modulation of the signal by the signal generator. A modular format is an advantageous embodiment of the invention that includes the removal of the frequency synthesizer's low phase noise reference into a separate module.Type: GrantFiled: November 18, 2020Date of Patent: May 30, 2023Assignee: Giga-tronics IncorporatedInventors: John R. Regazzi, Charles Lewis, Carlos Fuentes
-
Patent number: 11622841Abstract: A toothbrush system configured to be coupled to an external suction source. The toothbrush system includes a shaft with a main body with a first end and a second end, and a bristle array and a suction port arranged at the second end. The bristle array and the suction port both extend away from the shaft so that an opening of the suction port is proximal to a distal end of the bristle array. The shaft also includes a stem arranged at the first end. The stem includes a passageway that extends through the main body to provide a fluid connection to the suction port, and is configured to be coupled to the external suction source. Also, the handle is removably coupled to the shaft and includes a drive system operably coupled to the bristle array to actuate motion of the bristle array.Type: GrantFiled: July 9, 2021Date of Patent: April 11, 2023Assignee: Dignity HealthInventors: Virginia Prendergast, Cynthia Kleiman, Charles Lewis, Gary Lauterbach, Scott Castanon, Dylann Ceriani, Michael Williams
-
Publication number: 20230107858Abstract: Described herein is an impact device that may be slidably coupled to a wire rope barrier terminal end and, in the event of an impact on or about the terminal end by a vehicle, the impact device is configured to slide or advance along the terminal end wire rope(s) towards a wire rope barrier end and away from a terminal end anchor position. In a further embodiment, a method is described of retrofitting existing wire-rope barrier terminal ends with the device. The impact device may simultaneously (at least to some extent) absorb kinetic energy from the impact as well as redirect the direction of impact along the terminal end wire rope(s) towards, and optionally along, the wire rope barrier itself depending on the extent of impact. The sliding action also knocks over any posts in the direction of errant vehicle travel in an impact.Type: ApplicationFiled: February 12, 2021Publication date: April 6, 2023Applicant: FLETCHER BUILDING HOLDINGS LIMITEDInventors: Emerson Patrick James RYDER, Daniel Charles LEWIS
-
Publication number: 20230084620Abstract: A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient, the system including a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the pressurized respiratory gas is controlled by a microprocessor.Type: ApplicationFiled: July 22, 2022Publication date: March 16, 2023Applicant: ResMed Pty LtdInventors: Robert M. LANDIS, Charles A. LEWIS, Louis Javier COLLAZO, Chris Agami
-
Patent number: 11596758Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system. In one embodiment, a nasal cannula includes a base portion defining a first therapeutic gas passageway, a nozzle disposed adjacent the base portion and defining a second therapeutic gas passageway, the first passageway being in gaseous communication with the second passageway and a conduit configured to facilitate sensing that has an inlet side that is independent of and axially spaced apart from an outlet side of the nozzle. The conduit inlet side can extend beyond the nozzle outlet side of the nasal cannula. Additionally, the nasal cannula has a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's rare and a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare.Type: GrantFiled: July 28, 2021Date of Patent: March 7, 2023Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Publication number: 20220379056Abstract: A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient includes a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the respiratory gas is controlled by a microprocessor, a mixing area for mixing a first gas and a second gas in the respiratory gas flow pathway, a humidification area downstream of the mixing area and configured for humidifying respiratory gas in the respiratory gas flow pathway, and a heated delivery conduit for minimizing condensation of humidified respiratory gas.Type: ApplicationFiled: August 8, 2022Publication date: December 1, 2022Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Patent number: 11497407Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.Type: GrantFiled: July 28, 2021Date of Patent: November 15, 2022Inventors: Robert M. Landis, Charles A. Lewis, Louis Javier Collazo
-
Patent number: 11458270Abstract: A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient, the system including a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the pressurized respiratory gas is controlled by a microprocessor.Type: GrantFiled: April 21, 2016Date of Patent: October 4, 2022Inventors: Robert M Landis, Charles A Lewis, Louis Javier Collazo, Chris Agami