Patents by Inventor Charles Linder

Charles Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10729898
    Abstract: An apparatus comprises a cardiac signal sensing circuit configured for coupling electrically to a plurality of electrodes and to sense intrinsic cardiac activation at three or more locations within a subject's body using the electrodes; a stimulus circuit configured for coupling to the plurality of electrodes; a signal processing circuit electrically coupled to the cardiac signal sensing circuit and configured to determine a baseline intrinsic activation vector according to the sensed intrinsic cardiac activation; and a control circuit electrically coupled to the cardiac signal sensing circuit and stimulus circuit and configured to: initiate delivery of electrical pacing therapy using initial pacing parameters determined according to the baseline intrinsic activation vector; initiate sensing of a paced activation vector; and adjust one or more pacing therapy parameters according to the paced activation vector.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 4, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Allan Charles Shuros, Yinghong Yu, David J. Ternes, Michael J. Kane, William J. Linder
  • Publication number: 20200241095
    Abstract: A method of characterizing chemical and/or morphological features of a material, comprising acquiring energy relaxation data from 1H low field nuclear magnetic resonance (1H LF-NMR) measurements of said material, converting the relaxation signals into a multidimensional distribution of longitudinal and transverse relaxation times by solving an inverse problem under both L1 and L2 regularizations and further imposing a non-negativity constraint, and identifying one or more characteristics of said material with the aid of said multidimensional T1-T2 distribution. The method is useful, inter alia, in monitoring chemical processes, screening of additives and quality control.
    Type: Application
    Filed: September 6, 2019
    Publication date: July 30, 2020
    Inventors: Ze'ev WIESMAN, Charles LINDER, Ofer LEVI
  • Patent number: 10709892
    Abstract: Methods and devices for configuring the use of a motion sensor in an implantable cardiac device. The electrical signals of the patient's heart are observed and may be correlated to the physical motion of the heart as detected by the motion sensor of the implantable cardiac device in order to facilitate temporal configuration of motion sensor data collection that avoids detecting cardiac motion in favor of overall motion of the patient.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 14, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Michael J. Kane, William J. Linder, Benjamin J. Haasl, Paul Huelskamp, Keith R. Maile, Ron A. Balczewski, Bin Mi, John D. Hatlestad, Allan Charles Shuros
  • Publication number: 20200205383
    Abstract: A container for a nucleus hive of bees is provided including a box having a polygonal shaped bottom and a plurality of side walls. Each one of the plurality of side walls extends upwardly from an edge of the polygonal shaped bottom. A side edge of each side wall is attached to a side edge of an adjacent side wall and upper edges of the side walls form an opening. The opening has an area larger than the area of the polygonal shaped bottom and a shape substantially corresponding to the polygonal shaped bottom. A hive frame support means is positioned on inner wall surfaces of a plurality of the side walls. A polygonal shaped removable lid is configured to rest upon and cover the opening. The box and lid are preferably formed from a rigid commodity grade plastic material.
    Type: Application
    Filed: December 27, 2019
    Publication date: July 2, 2020
    Inventor: Charles Linder
  • Publication number: 20190381137
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: June 27, 2019
    Publication date: December 19, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20190216895
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2—L1—HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: November 12, 2018
    Publication date: July 18, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20190167991
    Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to detect an atrial fiducial and identify an atrial contraction based at least on part on the detected atrial fiducial. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart based at least in part on the identified atrial contraction, and can automatically switch or revert the ventricular pacing therapies on the fly.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 6, 2019
    Applicant: CARDIAC PACEMAKERS, INC.
    Inventors: Jeffrey E. Stahmann, Keith R. Maile, Krzysztof Z. Siejko, Allan Charles Shuros, William J. Linder, Benjamin J. Haasl, Brendan Early Koop, Michael J. Kane
  • Publication number: 20190167972
    Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to detect an artifact during ventricular filling and to identify an atrial event based at least on part on the detected artifact. Control circuitry of the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified atrial event.
    Type: Application
    Filed: November 27, 2018
    Publication date: June 6, 2019
    Applicant: CARDIAC PACEMAKERS, INC.
    Inventors: Jeffrey E. Stahmann, Keith R. Maile, Krzysztof Z. Siejko, Allan Charles Shuros, William J. Linder, Benjamin J. Haasl, Michael J. Kane, Brendan Early Koop
  • Publication number: 20190168008
    Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to identify a search window of time within a cardiac cycle to search for an atrial artifact. Control circuitry in the ventricular implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on an atrial event identified in the search window of time.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 6, 2019
    Applicant: CARDIAC PACEMAKERS, INC.
    Inventors: Keith R. Maile, Jeffrey E. Stahmann, Michael J. Kane, Benjamin J. Haasl, Krzysztof Z. Siejko, Allan Charles Shuros, William J. Linder, Brendan Early Koop
  • Publication number: 20190076533
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 14, 2019
    Inventors: Charles LINDER, Eliahu Heldman, Sarina Grinberg
  • Publication number: 20180220627
    Abstract: A package and system for holding and transporting small living beings, particularly, insects such as honeybees and the like, configurable in a robust, sturdy three-dimensional shape for handling and transport by mail and commercial carriers, which prevents stinging from within the package, allows escape of smaller accompanying insects such as hive beetles, is interlocking with others of the packages and strong enough to support other packages and items thereon; that provides for air flow through and about the package for heat dissipation for proper honeybee environment; that accommodates food and separately carrying a queen bee; and that can be easily and quickly broken down into a non-operational, generally flat configuration for initial sale, transport, and storage.
    Type: Application
    Filed: April 2, 2018
    Publication date: August 9, 2018
    Inventors: Charles Linder, Bryan S. Claerhout
  • Patent number: 9930869
    Abstract: A package and system for holding and transporting small living beings, particularly, insects such as honeybees and the like, configurable in a robust, sturdy three-dimensional shape for handling and transport by mail and commercial carriers, which prevents stinging from within the package, allows escape of smaller accompanying insects such as hive beetles, is interlocking with others of the packages and strong enough to support other packages and items thereon; that provides for air flow through and about the package for heat dissipation for proper honeybee environment; that accommodates food and separately carrying a queen bee; and that can be easily and quickly broken down into a non-operational, generally flat configuration for initial sale, transport, and storage.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: April 3, 2018
    Inventors: Charles Linder, Bryan S. Claerhout
  • Publication number: 20180036376
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 8, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20180021368
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: June 30, 2017
    Publication date: January 25, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20170367980
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Application
    Filed: May 9, 2017
    Publication date: December 28, 2017
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Patent number: 9717240
    Abstract: Method for the preparation of microencapsulated essential oils or a formulation thereof for various non-agricultural applications.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: August 1, 2017
    Assignee: BOTANOCAP LTD.
    Inventors: Arie Markus, Pnina Strongin, Charles Linder
  • Publication number: 20170189864
    Abstract: The present invention discloses stable composite membranes comprising a porous support having one or more thin selective layers coated on a top surface thereof, whereas at least one of said thin selective layers comprises a crosslinked fluorinated silicone polymer, and further wherein the total thickness of said one or more thin selective layers ranges between 0.1 to 10 microns. The use of these membranes in the process of olive oil wastewater treatment and the valorization of polyphenol-rich by-products, are also disclosed.
    Type: Application
    Filed: May 27, 2015
    Publication date: July 6, 2017
    Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
    Inventors: Jack GILRON, Charles LINDER, Zeev WIESMAN
  • Patent number: 9655359
    Abstract: Provided are microcapsules containing a solid core including at least one essential oil mixed with a porous solid material, where this solid core is coated by at least one layer of a polyurea film and/or a polyurethane film or an amphipathic shell composed of a multivalent salt form of at least one alkanoic acid. Further provided are compositions including these microcapsules, and uses thereof in a variety of agricultural and environmental applications.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: May 23, 2017
    Assignee: BOTANOCAP LTD.
    Inventors: Arie Markus, Charles Linder, Pnina Strongin
  • Patent number: 9642803
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 9, 2017
    Assignee: Ben-Gurion University Of The Negev Research And Development Authority
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Publication number: 20170014772
    Abstract: The present invention provides anion exchange membranes, processes for producing same and uses thereof. The anion exchange membranes according to embodiments of the present invention achieve a desirable combination of low resistance, high permselectivity and low degree of dimensional swelling. Anion exchange membranes according to embodiments of the present invention are also cost effective.
    Type: Application
    Filed: September 28, 2016
    Publication date: January 19, 2017
    Inventors: Charles Linder, Ora Kedem, Rami Messalem