Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through a combination of ex vivo gene therapy protocols and cell enchment, tumor cells are engineered to express an ? (1,3)galactosyl epitope and optionally the tumor associated antigens mesothelin and carcinoembryonic antigen. After administration of the compositions of the invention to patients, the production of increased antibody titers to certain cell-surface markers, including mesothelin, calreticulin, and carcinembryonic antigen (CEA) positively correlates with an increased overall survival.

Abstract: An automatic telephone service forwarding device including a base or enclosure defining a socket for receiving a wireless telephone. Upon detecting the presence of the wireless telephone in the socket, the device automatically forwards telephone service for the wireless telephone to a previously-stored forwarding directory number, typically the directory number of a wireline unit located nearby. Alternatively, the automatic telephone service forwarding device may be incorporated directly into a wireless telephone. In this case, the wireless telephone includes a “forward” button and a scrollable list of forwarding telephone numbers. The automatic telephone service forwarding device may also be configured to automatically select certain forwarding directory numbers from the list in accordance with a predefined time-based profile.

Abstract: A system notifies a computing device of an incoming message. In the system, a message server is coupled to a data communications network for receiving the incoming message, and a communications system is coupled to the message server so that the message server can communicate to the communications system that the incoming message awaits retrieval by the computing device. A communications line is coupled to the communications system and to the computing device so that the communications system can signal the computing device over the communications line that the incoming message awaits retrieval by such computing device. The computing device is for receiving the aforementioned notification and retrieving the incoming message from the message server, and includes a communications device for coupling with the aforementioned communications line.

Abstract: A portable communications device (PCD) is coupled to a first network by way of a second network. The PCD is normally in radio communication with the first network, and is coupled to the first network by way of the second network when the PCD is out of radio communication with the first network. In particular, the PCD is coupled to the second network, and is caused to leave a first network mode and enter a second network mode. A network connection is established with the first network by way of the second network, and communication with the first network is entered into by way of the second network.

Abstract: Methods and apparatus for secure over-the-air (OTA) programming, and particularly, activation, of a wireless unit in a particular communications system. The unit stores a stored key having been generated by using a key algorithm (K-algorithm) with an identifier associated with the unit as an input to the K-algorithm. The unit may receive information such as parameters and a verification number from a communications system for the purpose of programming the unit. The verification number is generated by using an authorization algorithm (A-algorithm) having the parameters and a key as A-algorithm inputs. They key is generated by the K-algorithm having the identifier associated with the K-algorithm input. In response to the receipt of the parameters and the verification number, the wireless unit generates a trial verification number by using the A-algorithm with the parameters and the stored key as trial inputs. The unit compares the verification number to the trial verification number for a match.

Abstract: An automatic telephone service forwarding device including a base or enclosure defining a socket for receiving a wireless telephone. Upon detecting the presence of the wireless telephone in the socket, the device automatically forwards telephone service for the wireless telephone to a previously-stored forwarding directory number, typically the directory number of a wireline unit located nearby. Alternatively, the automatic telephone service forwarding device may be incorporated directly into a wireless telephone. In this case, the wireless telephone includes a “forward” button and a scrollable list of forwarding telephone numbers. The automatic telephone service forwarding device may also be configured to automatically select certain forwarding directory numbers from the list in accordance with a predefined time-based profile.

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ? (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Abstract: One-component adhesives/sealants comprising surface-deactivated solid polyisocyanates and, optionally, isocyanate-reactive, liquid binders can be rapidly cured below the conventional thickening temperature by irradiating with microwaves, for example microwaves of at least 2 wavelengths. This process is particularly suitable for adhesively joining plastic substrates.

Abstract: Systems and methods for providing centralized notification for over the air programming. The centralized notification system includes a central server that generates a message to be delivered to a mobile device. The centralized notification system includes an active server in communication with the central server that receives the message from the central server. The active server communicates with a network element that communicates with the mobile device. The active server queries the network element to determine availability of the mobile device. If the availability of the mobile device is returned from the network device, the message is directly routed to the mobile device, otherwise, the message is routed to a passive server. The passive server monitors message traffic for an event that provides availability information about the mobile device and automatically delivers the message to the mobile device in response thereto.

Abstract: The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.

Abstract: A method and system for providing targeted advertisement information to consumers over a wireless communications network. In one embodiment, local advertisers register to advertise on certain wireless communications devices that are in close proximity to the advertiser. As a consumer enters a cell site that is near the location of the advertiser, the wireless network delivers a message to the wireless device that is specified by the local advertiser. An acknowledgement signal is then received by the network, and the local advertiser's account is charged for transmission of the advertisement. In a further embodiment, each of the messages stored in the database is also associated with one or more demographic codes, and users of wireless communications device select from one more demographic codes to describer their advertisement preferences.

Abstract: Interactively providing financial advice to an individual via a computer system includes: (a) receiving current information of the advisee, the current information including (i) data indicative of a current financial situation of the advisee including assets of the advisee, and (ii) data indicative of a currently intended future life event of the advisee; (b) determining a future financial obligation of the advisee that is representative of the intended future life event of the advisee; (c) determining a rate of return on investment that is required in order for the advisee to meet the future financial obligation based on the advisee's current financial situation; and (d) providing to the advisee a recommended asset allocation and an indication of the probability that the future financial obligation will be met based on the advisee's current financial situation and the recommended asset allocation. Assistance may be provided through a virtual human advisor.

Abstract: A method for treating tumors. Through infusion or xenotransplantation of xenogeneic cells, such as infusion of murine cells into the peritoneal cavity of humans, a hyperacute rejection response to the cells is induced. This in turn creates a bystander effect to the tumor. This effect creates tumor regression. This treatment can be used alone or in conjunction with gene therapy or chemotherapy treatments.

Abstract: Methods and compositions are disclosed to increase viral titer of vector producing cell lines and to reduce potential for re-infection by inhibiting deactivation of helper virus. According to the invention, methylation of helper virus and concomitant helper virus inactivation is directly correlated with increased super-infection and decreased vector production. Novel helper virus, packaging and producing cells and viral vectors are disclosed with improved safety and stability by decreasing helper virus inactivation.

Abstract: A method is described for the rapid identification and isolation of cells based on the presence or absence of an ectopically-expressed N-acetyllactosaminide 3-? Galactosyltransferase (?GT) enzyme for the production of ?Galactosyl-(1,3)Galactosyl (?Gal) epitopes on the surface of ?Gal-negative cells. These cells which are genetically modified to express the ?GT enzyme and ?Gal epitopes on glycosylated lipids and proteins of the cell surface are then labeled via an antibody composition which recognizes and binds the ?Gal epitopes on the cell surface. Cells labeled with the anti-?Gal antibody can be isolated by sorting via fluorescence activated cell sorting (FACS), or by magnetic panning techniques. This method is suitable for the rapid positive or negative selection of ?Gal-positive cells from within a population of ?Gal-negative cells without the need to expose cells to antibiotics for any period of time.

Abstract: The present invention provides an isolated population of adult hematopoietic stem cells (HSC) derived from embryonic stem cells (ESC) induced to differentiate in vitro by culturing ESCs in a medium with stem cell factor, interleukin (IL)-3, and IL-6. HSC of immunophenotype c-kit+ or c-kit+/CD45+ from this population are isolated and injected either intra bone marrow or intravenously into myeloablated recipient individuals. This method allows for the establishment of banks of allogeneic ESC-derived adult stem cells for treatments of autoimmune diseases, immune deficiencies and induction of immunotolerance during organ transplantation. These allogeneic ESC-derived adult hematopoietic stem cells (HSC) may be used in reconstituting bone marrow, without the development of teratomas or graft versus host disease, despite crossing histocompatibility barriers. Additionally, allogeneic ESC-derived HSC can be used to prevent the development of autoimmune diseases or organ rejection during transplantation.

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Abstract: A method of coupling a wireless portable communications device (PCD) to an electronic mail server network by way of a public wireless communications network is disclosed. The PCD is normally in communication with the electronic mail server network by way of a private wireless communications network, and is coupled to the electronic mail server network by way of the public wireless communications network when the PCD is out of communication with the electronic mail server network by way of the private wireless communications network. In particular, the PCD is coupled to the public wireless communications network, and is caused to leave an electronic mail server network mode and enter a public wireless communications network mode. A network connection is established with the electronic mail server network by way of the public wireless communications network, and communication with the electronic mail server network is entered into by way of the public wireless communications network.

Abstract: A portable communications device (PCD) is coupled to a first network by way of a second network. The PCD is normally in radio communication with the first network, and is coupled to the first network by way of the second network when the PCD is out of radio communication with the first network. In particular, the PCD is coupled to the second network, and is caused to leave a first network mode and enter a second network mode. A network connection is established with the first network by way of the second network, and communication with the first network is entered into by way of the second network.