Patents by Inventor Charles Lowenstein

Charles Lowenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of N-ethylmaleimide sensitive factor
    Patent number: 7910111
    Abstract: Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: March 22, 2011
    Assignee: The Johns Hopkins University
    Inventors: Charles Lowenstein, Kenji Matsushita, Craig Morrell
  • Inhibitors of n ethymalemide sensitive factor
    Publication number: 20070173441
    Abstract: Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.
    Type: Application
    Filed: April 15, 2004
    Publication date: July 26, 2007
    Inventors: Charles Lowenstein, Kenji Matsushita, Craig Morrell