Patents by Inventor Charles M. Lieber

Charles M. Lieber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190391112
    Abstract: There is provided a multi-channel nanopore sensor having a plurality of independent nanopore sensors. Each independent nanopore sensor includes a nanopore disposed in a support structure. A fluidic connection is between a first fluidic reservoir, common to all of the independent nanopore sensors, and an inlet to the nanopore, with a first ionic solution of a first ionic concentration disposed in the first fluidic reservoir. A fluidic connection is between a second fluidic reservoir, common to all of the independent nanopore sensors, and an outlet from the nanopore, with a second ionic solution of a second ionic concentration, different than the first ionic concentration, disposed in the second fluidic reservoir. An electrical transduction element, disposed in contact with that ionic solution having a lower ionic concentration, is arranged at a site that produces an electrical signal indicative of electrical potential local to that ionic solution having a lower ionic concentration.
    Type: Application
    Filed: August 29, 2019
    Publication date: December 26, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ping Xie
  • Patent number: 10436747
    Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: October 8, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ping Xie
  • Patent number: 10435817
    Abstract: The present invention generally relates to nanoscale wires, and to methods of producing nanoscale wires. In some aspects, the nanoscale wires are nanowires comprising a core which is continuous and a shell which may be continuous or discontinuous, and/or may have regions having different cross-sectional areas. In some embodiments, the shell regions are produced by passing the shell material (or a precursor thereof) over a core nanoscale wire under conditions in which Plateau-Raleigh crystal growth occurs, which can lead to non-homogenous deposition of the shell material on different regions of the core. The core and the shell each independently may comprise semiconductors, and/or non-semiconductor materials such as semiconductor oxides, metals, polymers, or the like. Other embodiments are generally directed to systems and methods of making or using such nanoscale wires, devices containing such nanoscale wires, or the like.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 8, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Robert Day, Max Nathan Mankin, Ruixuan Gao, Thomas J. Kempa
  • Patent number: 10369255
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 6, 2019
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, Children's Medical Center Corporation
    Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
  • Patent number: 10355229
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing cells or tissues, where the cell scaffolds comprise nanoscale wires. In some cases, the nanoscale wires can be connected to electronic circuits extending externally of the cell scaffold. Such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like. This approach thus allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 16, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Bozhi Tian, Jia Liu
  • Publication number: 20180328884
    Abstract: The present invention generally relates to injectable electronics. In some aspects, the present invention is generally directed to systems and methods for interfacing an electrical cable with electrical elements, such as nanoscale wires, that are injected or otherwise introduced into a subject. The subject may be living or non-living. In one set of embodiments, electrical elements introduced within a subject may be placed in electrical communication to a circuit board using a plurality of electrically isolated contacts that the circuit board can clamp or otherwise connect to. The electrical contacts may be in electrical communication with the electrical elements using a joining portion. The circuit board can also be connected to an electrical cable that can be attached, for example, to a computer. In some cases, the electrical cable can be attached or detached to or from the circuit board, e.g.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 15, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Gerard Schuhmann, Jun Yao, Guosong Hong, Tian-Ming Fu, Jungmin Lee, Hong-Gyu Park
  • Patent number: 10119955
    Abstract: A solid state molecular sensor having an aperture extending through a thickness of a sensing material is configured with a continuous electrically-conducting path extending in the sensing material around the aperture. A supply reservoir is connected to provide a molecular species, having a molecular length, from the supply reservoir to an input port of the aperture. A collection reservoir is connected to collect the molecular species from an output port of the aperture after translocation of the molecular species from the supply reservoir through the sensing aperture. The sensing aperture has a length between the input and output ports, in the sensing material, that is substantially no greater than the molecular length of the molecular species from the supply reservoir. An electrical connection to the sensing material measures a change in an electrical characteristic of the sensing material during the molecular species translocation through the aperture.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: November 6, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Qihua Xiong, Ping Xie, Ying Fang
  • Patent number: 10049871
    Abstract: The present invention generally relates to nanoscale wires, including anisotropic deposition in nanoscale wires. In one set of embodiments, material may be deposited on certain portions of a nanoscale wire, e.g., anisotropically. For example, material may be deposited on a first facet of a crystalline nanoscale wire but not on a second facet. In some cases, additional materials may be deposited thereon, and/or the portions of the nanoscale wire may be removed, e.g., to produce vacant regions within the nanoscale wire, which may contain gas or other species. Other embodiments of the invention may be directed to articles made thereby, devices containing such nanoscale wires, kits involving such nanoscale wires, or the like.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: August 14, 2018
    Assignees: President and Fellows of Harvard College, Korea University
    Inventors: Charles M. Lieber, Sun-Kyung Kim, Robert Day, Hong-Gyu Park, Thomas J. Kempa
  • Publication number: 20180224433
    Abstract: The present invention generally relates to nanoscale wires, nanoscale sensing elements, and/or injectable devices. In some embodiments, the present invention is directed to electronic devices that can be injected or inserted into soft matter, such as biological tissue or polymeric matrixes. For example, the device may be passed through a tube into the medium. To avoid or minimize crumpling, the device may exit the tube at substantially the same rate that the tube is withdrawn from the medium. Other components, such as fluids or cells, may also be injected or inserted. In addition, in some cases, the device, after insertion or injection, may be connected to an external electrical circuit, for example, by printing a conductive path on a medium or on a flexible substrate. The path may be printed using conductive inks, e.g., containing carbon nanotubes or other suitable materials.
    Type: Application
    Filed: August 4, 2016
    Publication date: August 9, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Guosong Hong, Tian-Ming Fu, Jinlin Huang, Tao Zhou
  • Publication number: 20180088079
    Abstract: The present invention generally relates to nanoscale wires and other nanomaterials, including nanoscale wires used as sensors, including nanoscale wires comprising semiconductor nanowires, carbon nanotubes, graphene, or metal oxide nanomaterials. Certain aspects of the invention are generally directed to polymer coating on nanoscale wires that can be used to increase sensitivity to analytes, for example, in physiologically relevant conditions. For example, the polymer may have an average pore size comparable in size to an analyte. Accordingly, in some cases, the nanoscale wires can be used as sensors, even in ionic solutions, e.g., under physiologically relevant conditions. Other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 29, 2018
    Inventors: Charles M. Lieber, Ning Gao, Wei Zhou, Xiaocheng Jiang, Teng Gao, Xiao Yang
  • Patent number: 9903862
    Abstract: The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid. In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: February 27, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ying Fang, Fernando Patolsky
  • Publication number: 20170352542
    Abstract: The present invention generally relates to nanoscale wires and, in particular, to nanoscale wires with heterojunctions, such as tip-localized homo- or heterojunctions. In one aspect, the nanoscale wire may include a core, an inner shell surrounding the core, and an outer shell surrounding the inner shell. The outer shell may also contact the core, e.g., at an end portion of the nanoscale wire. In some cases, such nanoscale wires may be used as electrical devices. For example a p-n junction may be created where the inner shell is electrically insulating, and the core and the outer shell are p-doped and n-doped. Other aspects of the present invention generally relate to methods of making or using such nanoscale wires, devices, or kits including such nanoscale wires, or the like.
    Type: Application
    Filed: October 29, 2015
    Publication date: December 7, 2017
    Inventors: Charles M. Lieber, Ruixuan Gao, Max Nathan Mankin, Robert Day, Hong-Gyu Park, You-Shin No
  • Patent number: 9786850
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing cells or tissues, where the cell scaffolds comprise nanoscale wires. In some cases, the nanoscale wires can be connected to electronic circuits extending externally of the cell scaffold. Such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like. This approach thus allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: October 10, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Bozhi Tian, Jia Liu
  • Publication number: 20170269029
    Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
    Type: Application
    Filed: June 7, 2017
    Publication date: September 21, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ping Xie
  • Patent number: 9702849
    Abstract: There is provided a nanopore disposed in a support structure, with a fluidic connection between a first fluidic reservoir and an inlet to the nanopore and a second fluidic connection between a second fluidic reservoir and an outlet from the nanopore. A first ionic solution of a first buffer concentration is disposed in the first reservoir and a second ionic solution of a second buffer concentration, different than the first concentration, is disposed in the second reservoir, with the nanopore providing the sole path of fluidic communication between the first and second reservoirs. An electrical connection is disposed at a location in the nanopore sensor that develops an electrical signal indicative of electrical potential local to at least one site in the nanopore sensor as an object translocates through the nanopore between the two reservoirs.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: July 11, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ping Xie
  • Publication number: 20170172438
    Abstract: The present invention generally relates to nanoscale wires and/or injectable devices. In some embodiments, the present invention is directed to electronic devices that can be injected or inserted into soft matter, such as biological tissue or polymeric matrixes. For example, the device may be passed through a syringe or a needle. In some cases, the device may comprise one or more nanoscale wires. Other components, such as fluids or cells, may also be injected or inserted. In addition, in some cases, the device, after insertion or injection, may be connected to an external electrical circuit, e.g., to a computer. Other embodiments are generally directed to systems and methods of making, using, or promoting such devices, kits involving such devices, and the like.
    Type: Application
    Filed: April 3, 2015
    Publication date: June 22, 2017
    Inventors: Charles M. LIEBER, Jia LIU, Zengguang CHENG, Guosong HONG, Tian-Ming FU, Tao ZHOU
  • Patent number: 9638717
    Abstract: The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe comprising a nanotube (or other nanoscale wire) is provided that can be directly inserted into a cell to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member positioned on a substrate, e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: May 2, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ruixuan Gao, Steffen Strehle, Xiaojie Duan, Bozhi Tian, Itzhaq Cohen-Karni, Ping Xie, Quan Qing
  • Publication number: 20170117147
    Abstract: The present invention generally relates to nanoscale wires, and to systems and methods of producing nanoscale wires. In some aspects, the present invention is generally related to facet-specific deposition on semiconductor surfaces. In one embodiment, a first surface of a nanoscale wire, or a semiconductor, is preferentially oxidized relative to a second surface, and material is preferentially deposited on the second surface relative to the first surface. For example, the nanoscale wire or semiconductor may be a silicon nanowire that is initially exposed to an etchant to remove silicon oxide, then exposed to an oxidant under conditions such that one facet or surface (e.g., a {113} facet) is oxidized more quickly than another facet or surface (e.g., a {111} facet). Material may then be deposited or immobilized on the less-oxidized facet relative to the more-oxidized facet.
    Type: Application
    Filed: June 11, 2015
    Publication date: April 27, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Max Nathan Mankin, Robert Day, Ruixuan Gao
  • Publication number: 20170072109
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.
    Type: Application
    Filed: July 21, 2016
    Publication date: March 16, 2017
    Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
  • Publication number: 20170073841
    Abstract: The present invention generally relates to nanoscale wires, and to methods of producing nanoscale wires. In some aspects, the nanoscale wires are nanowires comprising a core which is continuous and a shell which may be continuous or discontinuous, and/or may have regions having different cross-sectional areas. In some embodiments, the shell regions are produced by passing the shell material (or a precursor thereof) over a core nanoscale wire under conditions in which Plateau-Raleigh crystal growth occurs, which can lead to non-homogenous deposition of the shell material on different regions of the core. The core and the shell each independently may comprise semiconductors, and/or non-semiconductor materials such as semiconductor oxides, metals, polymers, or the like. Other embodiments are generally directed to systems and methods of making or using such nanoscale wires, devices containing such nanoscale wires, or the like.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 16, 2017
    Inventors: Charles M. Lieber, Robert Day, Max Nathan Mankin, Ruixuan Gao, Thomas J. Kempa