Patents by Inventor Charles M. Radding

Charles M. Radding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RecA nucleoprotein filament and methods
    Patent number: 4888274
    Abstract: A stable, single-stranded nucleoprotein filament adapted to complex specifically and stably with a target duplex DNA having a selected base sequence. The filament is composed of a single-stranded DNA probe having a region of homology with the target base sequence, and RecA protein bound stably to the DNA probe by adenosine 5'-(.gamma.-thio)triphosphate. The filament is useful in a novel system and method for enriching target duplex DNA which contains a region homologous to the probe sequence, for blocking selected restriction endonuclease sites in the target DNA, and in other DNA methodologies in which stable rapid triple-strand synaptic formation in duplex DNA can be exploited.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: December 19, 1989
    Assignee: Yale University
    Inventors: Charles M. Radding, Saul M. Honigberg, Sherman Weissman, Basil Rigas, Andrew A. Welcher, David C. Ward