Abstract: Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.

Abstract: Disclosed are methods, including automated methods, for identifying a compound that impacts a characteristic of a lipid raft phase domain, a characteristic of a non-raft phase domain, and/or a characteristic of one or more membrane proteins.

Abstract: Disclosed is a managed reliability storage system and method. A data storage system comprises a plurality of storage devices and at least one storage device controller and may also include additional storage device controllers, one or more host systems, and one or more network connections. Aspects of the invention include reliable data storage formats, planned reliability management, threshold reliability management, and software data recovery. Reliable data formats include fault tolerant storage formats such as RAID and implementations thereof. Planned reliability management includes monitoring of system usage and adjustment of usage reflecting an optimal usage model, scheduled and event driven diagnostic execution and conditional adjustment of operating parameters of storage system components. Software data recovery provides copying and reconstruction of data through redundant data formats including parity, ECC, RLL and others encoding methods.

Abstract: A disc drive device where data and servo position information is stored in data segments on concentric tracks on the disc surface. The servo position information indicates the track centerline for each data segment. The offset of the servo position information from an ideal track centerline for each track is measured and stored into memory. The read/write head, which accesses data on the disc tracks, is positioned over the track centerline based on the offset for each data segment.

Abstract: A controller in a hard disk drive system for controlling the transfer of data and control signals between a plurality of host processors and the disk drive system. The disk drive system including storage media, at least one transducer for recording data on and retrieving data from the storage media and an actuator for moving the transducers with respect to the storage media. The controller includes a programmed first microprocessor operating under control of a first operating system stored in a first memory unit associated with the first microprocessor for controlling the recording of data on and the retrieval of data from the storage media, the controlling of the actuator to locate the transducer at and to maintain the transducer at a specified location with respect to the storage media.

Abstract: A multi-layer data integrity system for use in a disk drive controller for ensuring the data integrity as data is transferred through the controller and written and fetched from the disk media. The disk drive controller is partitioned into an interface controller and a low level controller where the interface controller controls the transfer of data to and from the host processor and the low level controller controls the recording and reading from the disk media. The interface controller employs a first error encoding and detecting means for encoding the data as originally received from the host processor. The low level controller employs an error encoding and detecting means for encoding both the received data and the encoding data which was appended to the data received by the interface controller. The low level controller's error encoding and detecting means corrects errors detected in recovered data.

Abstract: A multiple actuator disk drive utilizes multiple heads, associated with respective ones of multiple actuators, to read data from and write data to all tracks on the surface of a disk. The positioning of each head by the respective actuator is controlled by embedded servo-information recorded in the data tracks. The data tracks have a density of greater than 2000 tracks per inch. Utilizing two actuators provides access times which are reduced with respect to the access times provided by disk drives having a single actuator and an increased data transfer rate.

Abstract: A device for pulling the starter cord of a lawn mower engine utilizes a pulling cable attached to a pulley wheel activated by a high torque electric motor. An elongated base supports an upright post, upon which the motor is mounted. A chute protectively guides the cable as it spans the distance between the pulley wheel and starter cord. A restoring cable, in association with a return wheel and coil spring unwind the pulling cord from the pulley wheel when the motor is deactivated.

Abstract: A high level controller for maintaining communication with a host processor via a host processor interface for establishing communication paths between the host processor interface, an internal processor and a plurality of storage means. A first means receives indicia from the internal processor where the indicia specifies one of the communication paths and generates control signals for forming the specific communication path requested. A second means receives the control signals from the first means and forms the requested communication path. A third means is connected to the first and second means for controlling the communication of the system with the host processor interface in accordance with control signals generated by the first means. In this manner various data paths for communication between the host interface, internal processor and a plurality of storage means may be adaptably specified and formed to make optimum use of the system.

Abstract: A disk drive architecture controls the transfer of data between a host processor interface and a recording media that includes one or more disk surfaces for storing data. A low-level data controller controls the transfer of data between the disk surfaces and a data buffer. An interface controller controls the transfer of data between the host interface and the data buffer. An arbiter and buffer controller, responsive to data transfer requests from the low-level and interface controllers, arbitrates data storage and retrieval accesses of the data buffer. The low-level and interface controllers operate substantially independent of one another in performing their respective control operations. Consequently, data is transferred bi-directionally through the data buffer at the optimum timing for both controllers.

Abstract: A device for pulling the starter cord of a lawn mower engine utilizes a pulling cable disposed about upper and lower pulleys on a vertical post. The upper extremity of the pulling cable is attached to a lever pivotally joined to the vertical post. Downward movement of the lever causes the starter cord to be pulled horizontally.

Abstract: A multiple actuator disk drive utilizes multiple heads, associated with respective ones of multiple actuators, to read data from and write data to all tracks on the surface of a disk. The positioning of each head by the respective actuators is controlled by embedded servo-information recorded in the data tracks. The data tracks have a density of greater than 2000 tracks per inch. Utilizing two actuators provides access times which are reduced with respect to the access times provided by disk drives having a single actuator and an increased data transfer rate.

Abstract: The head assembly of a disc drive device is retracted upon the interruption of power to that device by utilizing the emf that is generated by the disc drive spindle motor as a result of the rotation of that motor following power interruption. Then, after a delay sufficient to allow the head assembly time to retract, the spindle motor is dynamically braked. Dynamic braking is achieved by utilizing a voltage to which a capacitor has been charged during normal operation to energize switching elements which effectively short circuit the motor windings.