Abstract: A flow-through microfluidic NMR-chip comprising a substrate (5) which is planar in an yz-plane with a sample chamber (2) within the substrate (5), the sample chamber (2) being elongated and having walls which run parallel to the z-direction, the substrate (5) having a thickness in x-direction of a Cartesian xyz-coordinate system between 100 ?m and 2 mm, and at least one planar receiving and/or transmission coil (1, 1?) with conductor sections (11) the coil (1, 1?) being arranged at least on one planar surface of the substrate (5), wherein the extension of the sample chamber (2) along the z-direction exceeds the extension of the coil (1) along the z-direction is characterized in that the extension of the coil (1, 1?) along the z-direction is larger than its extension along the y-direction. The inventive NMR-chip facilitated NMR-spectroscopic measurements with improved resolution, sensitivity as well as B1 homogeneity.

Abstract: A nuclear magnetic resonance (NMR) probe component, comprising a microfabricated planar gradient chip (1), with a substrate thickness dgc?3 mm, carrying three micromachined planar partial gradient coils (10a-10f) on each of its two outer surfaces (12a, 13a), wherein the partial gradient coils (10a-10f) of the gradient chip (1) form a three-dimensional gradient system, wherein the gradient chip (1) has a central guiding and positioning slot (15) between the two outer surfaces (12a, 13a). The probe component also has a sample chip (2) for carrying an NMR sample at a sample location, with a microfabricated planar RF coil (21), wherein the sample chip (2) fits exactly in the guiding and positioning slot (15) such that in a measurement position, the sample location coincides with the center of the gradient system. The NMR probe component has improved spatial resolution and allows good alignment of the RF coil and the gradient system.

Abstract: A flow-through microfluidic NMR-chip comprising a substrate (5) which is planar in an yz-plane with a sample chamber (2) within the substrate (5), the sample chamber (2) being elongated and having walls which run parallel to the z-direction, the substrate (5) having a thickness in x-direction of a Cartesian xyz-coordinate system between 100 ?m and 2 mm, and at least one planar receiving and/or transmission coil (1, 1?) with conductor sections (11) the coil (1, 1?) being arranged at least on one planar surface of the substrate (5), wherein the extension of the sample chamber (2) along the z-direction exceeds the extension of the coil (1) along the z-direction is characterized in that the extension of the coil (1, 1?) along the z-direction is larger than its extension along the y-direction. The inventive NMR-chip facilitated NMR-spectroscopic measurements with improved resolution, sensitivity as well as B1 homogeneity.

Abstract: A nuclear magnetic resonance (NMR) probe component, comprising a microfabricated planar gradient chip (1), with a substrate thickness dgc?3 mm, carrying three micromachined planar partial gradient coils (10a-10f) on each of its two outer surfaces (12a, 13a), wherein the partial gradient coils (10a-10f) of the gradient chip (1) form a three-dimensional gradient system, wherein the gradient chip (1) has a central guiding and positioning slot (15) between the two outer surfaces (12a, 13a). The probe component also has a sample chip (2) for carrying an NMR sample at a sample location, with a microfabricated planar RF coil (21), wherein the sample chip (2) fits exactly in the guiding and positioning slot (15) such that in a measurement position, the sample location coincides with the center of the gradient system. The NMR probe component has improved spatial resolution and allows good alignment of the RF coil and the gradient system.