Patents by Inventor Charles MCHUGH
Charles MCHUGH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884978Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.Type: GrantFiled: September 30, 2016Date of Patent: January 30, 2024Assignee: IMMUNEXPRESS PTY LTDInventors: Richard Bruce Brandon, Brian Andrew Fox, Leo Charles McHugh, Dayle Lorand Sampson
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Publication number: 20230418453Abstract: A client device having a user interface, and a display displaying a graphical slider on the display that is associated with a theme of digital media content. A processor is responsive to a user moving the displayed slider between a first position and a second position, wherein the first position is correlated to a first type of digital media content and the second position is correlated to a second type of digital media content. The processor uses the position of the slider as search criteria and searches uniform resource locator (URL) content of a server that is associated with the theme of digital media content. The processor returns selected digital media content that correlates to the type of media content as a function of the slider position.Type: ApplicationFiled: June 27, 2023Publication date: December 28, 2023Inventors: Jonathan Cefalu, Jeremy Charles McHugh, Dylan Hadfield-Menell
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Publication number: 20230359902Abstract: A system for use with an artificial intelligence (AI) model configured to accept text input, such as generative pre-trained transformer (GPT), that detects and tags trusted instructions and nontrusted instructions of an input provided by a user responsive to an AI model prompt. The system uses reinforcement learning (RL) and a set of rules to remove the untrusted instructions from the input and provide only trusted instructions to the AI model. The input is represented as tokens, wherein the trusted instructions and the untrusted instructions are represented using incompatible token sets.Type: ApplicationFiled: May 4, 2023Publication date: November 9, 2023Inventors: Jonathan CEFALU, Jeremy Charles MCHUGH, Ron HEICHMAN
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Publication number: 20230359903Abstract: A system for use with an artificial intelligence (AI) model configured to accept text input, such as generative pre-trained transformer (GPT), that detects and tags trusted instructions and nontrusted instructions of an input provided by a user responsive to an AI model prompt. The system uses reinforcement learning (RL) and a set of rules to remove the untrusted instructions from the input and provide only trusted instructions to the AI model. The input is represented as tokens, wherein the trusted instructions and the untrusted instructions are represented using incompatible token sets.Type: ApplicationFiled: May 4, 2023Publication date: November 9, 2023Inventors: Jonathan CEFALU, Jeremy Charles MCHUGH, Ron HEICHMAN
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Publication number: 20220325348Abstract: The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. Also disclosed is a biomarker signature for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. The present invention further discloses methods, kits and apparatus, as well as reagents and compositions associated therewith, for identifying biomarkers for use in a biomarker signature.Type: ApplicationFiled: February 23, 2022Publication date: October 13, 2022Inventors: Richard Bruce BRANDON, Leo Charles MCHUGH
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Publication number: 20220243272Abstract: Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected or suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.Type: ApplicationFiled: September 22, 2021Publication date: August 4, 2022Inventors: Richard Bruce BRANDON, Leo Charles MCHUGH
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Publication number: 20220042989Abstract: Disclosed are methods, apparatus, kits and compositions for determining the absence of a systemic bacterial infection (sepsis) in patients, particularly ones presenting to hospital emergency departments (ED) as outpatients, by measurement of the host immune response using peripheral blood. The are methods, apparatus, kits and compositions can be used in mammals for diagnosing, making treatment decisions, determining the next procedure or diagnostic test, or management of patients suspected of having an infection, including those presenting with fever or other signs of systemic inflammation. More particularly, peripheral blood RNA and protein biomarkers are disclosed that are useful for distinguishing between the host immune response to bacteria compared to the host immune response to other causes of systemic inflammation including trauma, burns, autoimmune disease, asthma, anaphylaxis, arthritis, obesity and viral infections.Type: ApplicationFiled: October 29, 2021Publication date: February 10, 2022Inventors: Richard Bruce BRANDON, Brian Andrew FOX, Leo Charles MCHUGH, Dayle Lorand SAMPSON
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Patent number: 11047010Abstract: The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. Also disclosed is a biomarker signature for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. The present invention further discloses methods, kits and apparatus, as well as reagents and compositions associated therewith, for identifying biomarkers for use in a biomarker signature.Type: GrantFiled: February 6, 2015Date of Patent: June 29, 2021Assignee: ImmuneXpress Pty LtdInventors: Richard Bruce Brandon, Leo Charles McHugh
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Publication number: 20210139991Abstract: Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected or suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.Type: ApplicationFiled: November 18, 2020Publication date: May 13, 2021Inventors: Richard Bruce BRANDON, Leo Charles MCHUGH
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Patent number: 10975437Abstract: Disclosed are methods for treating or inhibiting the development of infection-negative systemic inflammatory response syndrome (inSIRS) or infection-positive systemic inflammatory response syndrome (ipSIRS) based on the use of complement component 3a receptor 1 (C3AR1) as a biomarker for differentiating between inSIRS and ipSIRS.Type: GrantFiled: November 8, 2018Date of Patent: April 13, 2021Assignee: ImmuneXpress Pty LtdInventors: Richard Bruce Brandon, Leo Charles McHugh
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Patent number: 10865447Abstract: The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. Also disclosed is a biomarker signature for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. The present invention further discloses methods, kits and apparatus, as well as reagents and compositions associated therewith, for identifying biomarkers for use in a biomarker signature.Type: GrantFiled: May 15, 2015Date of Patent: December 15, 2020Assignee: ImmuneXpress Pty LtdInventors: Richard Bruce Brandon, Leo Charles McHugh
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Publication number: 20200371099Abstract: Disclosed are methods, apparatus, kits and compositions for determining the absence of a systemic bacterial infection (sepsis) in patients, particularly ones presenting to hospital emergency departments (ED) as outpatients, by measurement of the host immune response using peripheral blood. The are methods, apparatus, kits and compositions can be used in mammals for diagnosing, making treatment decisions, determining the next procedure or diagnostic test, or management of patients suspected of having an infection, including those presenting with fever or other signs of systemic inflammation. More particularly, peripheral blood RNA and protein biomarkers are disclosed that are useful for distinguishing between the host immune response to bacteria compared to the host immune response to other causes of systemic inflammation including trauma, burns, autoimmune disease, asthma, anaphylaxis, arthritis, obesity and viral infections.Type: ApplicationFiled: December 22, 2016Publication date: November 26, 2020Inventors: Richard Bruce BRANDON, Brian Andrew FOX, Leo Charles MCHUGH, Dayle Lorand SAMPSON
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Patent number: 10719579Abstract: A method for validating quantification of biomarkers, the biomarkers being quantified using a quantification technique of a selected type, and the method including determining a plurality of biomarker values, each biomarker value being indicative of a value measured or derived from a measured value, for at least one corresponding biomarker of the biological subject and being at least partially indicative of a concentration of the biomarker in a sample taken from the subject, determining at least one control value by determining a combination of biomarker values, comparing each control value to a respective control reference and determining if the biomarker values are valid using results of the comparison.Type: GrantFiled: May 20, 2016Date of Patent: July 21, 2020Assignee: IMMUNEXPRESS PTY LTDInventor: Leo Charles McHugh
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Publication number: 20190330696Abstract: Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected of suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.Type: ApplicationFiled: November 8, 2018Publication date: October 31, 2019Inventors: Richard Bruce Brandon, Leo Charles Mchugh
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Publication number: 20190194728Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring an infection by a bacterium, virus or protozoan by measurement of pathogen-associated and non-infectious systemic inflammation and optionally in combination with detection of a pathogen specific molecule. The invention can be used for diagnosis, including early diagnosis, ruling-out, ruling-in, monitoring, making treatment decisions, or management of subjects suspected of, or having, systemic inflammation. More particularly, the present disclosure relates to host peripheral blood RNA and protein biomarkers, which are used in combination, and optionally with peripheral blood broad-range pathogen-specific detection assays, that are useful for distinguishing between bacterial, viral, protozoal and non-infectious causes of systemic inflammation.Type: ApplicationFiled: August 24, 2017Publication date: June 27, 2019Inventors: Richard Bruce BRANDON, Dayle Lorand SAMPSON, Leo Charles MCHUGH
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Patent number: 10190169Abstract: Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected of suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.Type: GrantFiled: June 18, 2014Date of Patent: January 29, 2019Assignee: ImmuneXpress Pty LtdInventors: Richard Bruce Brandon, Leo Charles McHugh
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Patent number: 10167511Abstract: Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected of suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.Type: GrantFiled: July 2, 2016Date of Patent: January 1, 2019Assignee: IMMUNEXPRESS PTY LTDInventors: Richard Bruce Brandon, Leo Charles McHugh
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Publication number: 20180305760Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.Type: ApplicationFiled: September 30, 2016Publication date: October 25, 2018Inventors: Richard Bruce BRANDON, Brian Andrew FOX, Leo Charles MCHUGH, Dayle Lorand SAMPSON
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Publication number: 20180107783Abstract: A method for validating quantification of biomarkers, the biomarkers being quantified using a quantification technique of a selected type, and the method including determining a plurality of biomarker values, each biomarker value being indicative of a value measured or derived from a measured value, for at least one corresponding biomarker of the biological subject and being at least partially indicative of a concentration of the biomarker in a sample taken from the subject, determining at least one control value by determining a combination of biomarker values, comparing each control value to a respective control reference and determining if the biomarker values are valid using results of the comparison.Type: ApplicationFiled: May 20, 2016Publication date: April 19, 2018Inventor: Leo Charles MCHUGH
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Publication number: 20170191129Abstract: The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. Also disclosed is a biomarker signature for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. The present invention further discloses methods, kits and apparatus, as well as reagents and compositions associated therewith, for identifying biomarkers for use in a biomarker signature.Type: ApplicationFiled: February 6, 2015Publication date: July 6, 2017Inventors: Richard Bruce BRANDON, Leo Charles MCHUGH