Patents by Inventor Charles Mi

Charles Mi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for combining protein precipitation and solid phase extraction
    Patent number: 10928366
    Abstract: A composition, method and device for the preparation of biological samples for subsequent LC-MS analysis using a combined and concurrent protein precipitation and solid phase extraction (SPE) process is described. Through an integrated combination of protein precipitation, filtration, and SPE using a novel zirconia-coated chromatographic media, interfering compounds, such as proteins and phosphate-containing compounds, are eliminated from the biological samples, affording a higher degree of analyte response during LC-MS analysis.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: February 23, 2021
    Assignee: Sigma-Aldrich Co. LLC
    Inventors: Craig Aurand, Charles Mi, Paul Ross, An Trinh, Hillel Brandes, Michael Ye
  • COMPOSITIONS AND METHODS FOR COMBINING PROTEIN PRECIPITATION AND SOLID PHASE EXTRACTION
    Publication number: 20080213906
    Abstract: A composition, method and device for the preparation of biological samples for subsequent LC-MS analysis using a combined and concurrent protein precipitation and solid phase extraction (SPE) process is described. Through an integrated combination of protein precipitation, filtration, and SPE using a novel zirconia-coated chromatographic media, interfering compounds, such as proteins and phosphate-containing compounds, are eliminated from the biological samples, affording a higher degree of analyte response during LC-MS analysis.
    Type: Application
    Filed: January 24, 2008
    Publication date: September 4, 2008
    Applicant: SIGMA ALDRICH COMPANY
    Inventors: Craig Aurand, Charles Mi, Paul Ross, An Trinh, Hillel Brandes, Michael Ye