Abstract: An edge cleaning device, a system for cleaning an outside edge of a movable, coated web, and a method of cleaning the outside edge of the movable, coated web include a unique combination of desirable features. An edge cleaner device is automatically positioned with respect to an outside edge of a movable, coated web, wherein the edge cleaner device is positioned upstream from a backing roller for operatively engaging an underside of the moving, coated web. A fluid jet from a nozzle assembly of the edge cleaner device is applied toward the underside and the outside edge of the moving, coated web. A scraper device can be operatively engaged with an upper surface of the moving web without contacting an upper surface of the backing roller and the collection device may be imparted with a vacuum to assist in the removal of excess coating collected by the edge cleaning device.

Abstract: A method of treating tissue lyophilizes a biocompatible polymer having a functionality equal to or greater than three. The method provides a protein solution. The method mixes the protein solution with the lyophilized polymer to reconstitute the polymer and form a mixture, wherein, upon mixing, the protein solution and the polymer cross-link to form a material composition. The method applies the material composition to a tissue region. The biocompatible polymer can comprise, e.g., poly(ethylene glycol) PEG. The protein solution can comprise, e.g., albumin.

Abstract: Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.

Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.

Abstract: An subcutaneously implantable device for delivering Risperidone to a patient includes a pump, a compartment configured to store a pharmaceutical formulation, and a volume of the pharmaceutical formulation loaded in the compartment, the pharmaceutical formulation including Risperidone solvated or suspended in a pharmaceutically acceptable solvent in concentration of at least 50 milligrams per milliliter. The implanted pump may then deliver a therapeutically effective dose of Risperidone to the patient.

Abstract: A catherer system and method are provided including a blunt end assembly with a catheter and a blunt end member. The blunt end member includes jaw sections which have a first position or closed position for locating the blunt end member at the site of the occlusion within the native lumen of the blood vessel and a second position or open position wherein the jaw sections are able to press against the interior walls of the lumen adjacent the occlusion. The assembly includes an actuation member for moving the jaw sections from the closed to the open positions repeatedly resulting in a fracturing of the occlusion. A guide wire may be thread through an internal opening in the catheter and the blunt end member and after fracturing, across the occlusion.

Abstract: Disclosed herein is an articulated guidewire for insertion into a blood vessel. The articulated guidewire includes a rotatable sensor cable, a sensor, a connector, and a satellite wire. The sensor cable has a proximal end and a distal end. A sensor connects to the sensor cable near the distal end and rotates with the sensor cable. The satellite wire attaches to the distal end of the sensor cable and holds the sensor cable in the blood vessel. The connector includes a ball and socket joint which aligns the satellite wire and the sensor cable at a variable angle.

Abstract: Disclosed herein is a blunt end assembly including a catheter and a blunt end member. The blunt end member includes jaw sections which have a first closed position for locating the blunt end member at the site of the occlusion within the native lumen of the blood vessel and a second open position wherein the jaw sections are able to press against the interior walls of the lumen adjacent the occlusion. The assembly includes an actuation member for moving the jaw sections from the closed to the open positions repeatedly resulting in a fracturing of the occlusion. A guide wire may be thread through an internal opening in the catheter and the blunt end member and after fracturing across the occlusion.

Abstract: A method and apparatus are provided for imaging a narrow body lumen, the method comprising maintaining separation between a distal end of an optical viewing scope and a lumen wall with a spacing structure which extends distally from the distal end of an access catheter. Optional spacing structures include distal cages and a guidewire which is fixed to and extends distally from the access catheter body. The invention is beneficial during either retrograde imaging of the fallopian tube, and also allows antigrade imaging and advancing the access catheter and scope under the direction of the image provided, as it prevents the tubal wall from coming into such close proximity to a falloposcope as to produce “white-out” on the imaging monitor.

Abstract: An athetectomy catheter is disclosed having a composite cutter which is capable of cutting material, including hardened plaque, from a biological conduit. The composite cutter has a cutter and a sensor mount. The cutter has a proximal end and a distal end with a cutting edge. The proximal end of the cutter bonds with the sensor mount. The sensor mount is adaptable for holding a sensor and attaching to a cutter torque cable of an atherectomy catheter. Typically, the atherectomy catheter has a cutter housing with a window. The composite cutter is positioned in the cutter housing and moves in response to movement of the cutter torque cable to cut material from the biological conduit via the window.

Abstract: Disclosed herein is an intravascular catheter system for crossing a severe or total arterial occlusion; particularly, a steerable intravascular catheter providing a working element and the optical guidance thereof in crossing an occlusion. Also disclosed is a method of crossing a severe or total arterial occlusion with a steerable catheter working element under optical guidance.

Abstract: An intravascular catheter system for crossing a severe or total arterial occlusion includes a steerable intravascular catheter providing a working element and an optical guidance system. The optical guidance system is realized by an optical member with may include an imaging shaft that is rotated and measured by a motor/encoder assembly or which may include an optical switching device connected to a plurality of optical fibers. The working element may include a plurality of opening members that are actuated by an external plunger.

Abstract: Disclosed herein is a blunt end assembly including a catheter and a blunt end member. The blunt end member includes jaw sections which have a first closed position for locating the blunt end member at the site of the occlusion within the native lumen of the blood vessel and a second open position wherein the jaw sections are able to press against the interior walls of the lumen adjacent the occlusion. The assembly includes an actuation member for moving the jaw sections from the closed to the open positions repeatedly resulting in a fracturing of the occlusion. A guide wire may be thread through an internal opening in the catheter and the blunt end member and after fracturing, across the occlusion.

Abstract: A method and apparatus are provided for imaging a narrow body lumen, the method comprising maintaining separation between a distal end of an optical viewing scope and a lumen wall with a spacing structure which extends distally from the distal end of an access catheter. Optional spacing structures include distal cages and a guidewire which is fixed to and extends distally from the access catheter body. The invention is particularly beneficial during retrograde imaging of the fallopian tube, as it prevents the tubal wall from coming into such close proximity to a falloposcope as to produce "white-out" on the imaging monitor.

Abstract: A method and apparatus are provided for imaging a narrow body lumen, the method comprising maintaining separation between a distal end of an optical viewing scope and a lumen wall with a spacing structure which extends distally from the distal end of an access catheter. Optional spacing structures include distal cages and a guidewire which is fixed to and extends distally from the access catheter body. The invention is beneficial during either retrograde imaging of the fallopian tube, and also allows antigrade imaging and advancing the access catheter and scope under the direction of the image provided, as it prevents the tubal wall from coming into such close proximity to a falloposcope as to produce "white-out" on the imaging monitor.

Abstract: Disclosed herein is an articulated guidewire for insertion into a blood vessel. The articulated guidewire includes a rotatable sensor cable, a sensor, a connector, and a satellite wire. The sensor cable has a proximal end and a distal end. A sensor connects to the sensor cable near the distal end and rotates with the sensor cable. The satellite wire attaches to the distal end of the sensor cable and holds the sensor cable in the blood vessel. The connector includes a ball and socket joint which aligns the satellite wire and the sensor cable at a variable angle.

Abstract: A flexible composite drive shaft used with a flexible vascular atherectomy catheter for connecting a proximal rotating drive member and a distal rotatable working member. The flexible composite drive shaft includes a core of specially selected highly elastic shape memory alloy surrounded by a flexible torsional reinforcing helical wound member and a covering of a smooth polymeric material penetrating the interstices between the wound member and the outer surface of the core. The material of the core, the relative winding direction of the reinforcing member and the direction of angular offset between the reinforcing member and the core are selected to optimize the consistency of the rotational characteristics of the drive shaft in use.

Abstract: Disclosed herein is manual actuator for retracting and advancing a therapeutic working element of an intravascular catheter system via an actuation shaft or one or more pulling wires. The manual actuator includes a hollow cylindrical bracing member having an open proximal end and a distal end, and a hollow cylindrical retracting member, the retracting member being slidable, in a telescoping fashion, into the open proximal end of the bracing member. An actuation shaft is secured near to the proximal end of the retracting member and the distal end of the actuation shaft is secured to the therapeutic working element. Alternatively, at least one pulling wire is secured proximal to the proximal end of the retracting member. The distal end of the pulling wire is secured to the therapeutic working element. At least one resilient connecting member has a proximal end attached proximate the proximal end of the retracting member, and a distal end attached proximate the distal end of the bracing member.

Abstract: An athetectomy catheter is disclosed having a composite cutter which is capable of cutting material, including hardened plaque, from a biological conduit. The composite cutter has a cutter and a sensor mount. The cutter has a proximal end and a distal end with a cutting edge. The proximal end of the cutter bonds with the sensor mount. The sensor mount is adaptable for holding a sensor and attaching to a cutter torque cable of an atherectomy catheter. Typically, the atherectomy catheter has a cutter housing with a window. The composite cutter is positioned in the cutter housing and moves in response to movement of the cutter torque cable to cut material from the biological conduit via the window.

Abstract: A method and apparatus are provided for imaging a narrow body lumen, the method comprising maintaining separation between a distal end of an optical viewing scope and a lumen wall with a spacing structure which extends distally from the distal end of an access catheter. Optional spacing structures include distal cages and a guidewire which is fixed to and extends distally from the access catheter body. The invention is particularly beneficial during retrograde imaging of the fallopian tube, as it prevents the tubal wall from coming into such close proximity to a falloposcope as to produce "white-out" on the imaging monitor.