Patents by Inventor Charles Mioskowski

Charles Mioskowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8304545
    Abstract: The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: November 6, 2012
    Assignee: Pierre Fabre Medicament
    Inventors: Charles Mioskowski, Vanessa Gonnot, Rachid Baati, Marc Nicolas
  • Patent number: 8158784
    Abstract: The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: April 17, 2012
    Assignee: Pierre Fabre Medicament
    Inventors: Charles Mioskowski, Vanessa Gonnot, Rachid Baati, Marc Nicolas
  • Publication number: 20120088917
    Abstract: The invention relates to a 1-aza-bicyclo [2.2.2] oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.
    Type: Application
    Filed: December 7, 2011
    Publication date: April 12, 2012
    Inventors: Charles MIOSKOWSKI, Vanessa Gonnot, Rachid Baati, Marc Nicolas
  • Patent number: 7732541
    Abstract: The invention relates to polymers comprising a sequence of units comprising an ethylenic unsaturation, the unsaturation being located every 3 carbon atoms between two successive units. The invention also relates to processes for preparing such polymers.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: June 8, 2010
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Thierry Le Gall, Jean-Philippe Goddard, Charles Mioskowski
  • Publication number: 20100105897
    Abstract: The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.
    Type: Application
    Filed: January 17, 2008
    Publication date: April 29, 2010
    Applicant: Pierre Fabre Medicament
    Inventors: Charles Mioskowski, Vanessa Gonnot, Rachid Baati, Marc Nicolas
  • Patent number: 7517587
    Abstract: The invention relates to macromolecules auto-assembled and photopolymerised around carbon nanotubes. Said macromolecules are essentially formed from rings of lipid compounds, polymerised about the nanotubes, said polymerised compounds being obtained from lipid molecules with one or two chains A, bonded to a group Z where A is a chain, CH3—(CH2)m—C?C—C?C—(CH2)n—, where n and m, independently=whole numbers from 1 to 16 and Z is a polar head group embodied by a —COOH, —CO—NH—Y, —NH2 or N+(R)3, where R is an alkyl with C1, to C4 and Y is a —(CH2)4—C(R1)—N(CH2—COOH)2 group with R=H, or a COOH group, where A is a single lipid chain or a group of structure (I) or (II), where R2=a COOH, or —CO—NH—Y1 group with Y1=a —(CH2)4—C (R3)—N(CH2COOH)2 group with R3=H or a COOH group, where Z and R2 can also be neutral polar head groups of the sugar or polysaccharide type.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: April 14, 2009
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite Louis Pasteur
    Inventors: Charles Mioskowski, Stéphane Rickling, Patrick Schultz
  • Patent number: 7420087
    Abstract: The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: September 2, 2008
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite Louis Pasteur
    Inventors: Charles Mioskowski, Alain Wagner, Sandra De Lamo Marin, Cedric Catala, Jean-Michel Becht
  • Patent number: 7361668
    Abstract: The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: April 22, 2008
    Assignee: UCB, S.A.
    Inventors: Michel Guyaux, Chimmanamada U. Dinesh, Charles Mioskowski, Luc Quere, Jean-Philippe Starck, Patrice Talaga, Alain Wagner, Matteo Zanda
  • Patent number: 7326805
    Abstract: The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids ? or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, R1 and R2 represent: a hydrogen atom; or either R1 or R2 represents a hydrogen atom and the other substituent is a radical Ra, an acyl group —CORa, such as acetyl, or a functional group —COORa, —SO2Ra, —N (Ra, Rb), Ra and Rb, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or R1 and R2 both represent a substituent as defined above. R3 represents a hydrogen atom or Ra and R4 has the significance of Ra.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: February 5, 2008
    Inventors: Charles Mioskowski, Cédric Catala, Alain Wagner
  • Publication number: 20070184267
    Abstract: The invention relates to macromolecules auto-assembled and photopolymerised around carbon nanotubes. Said macromolecules are essentially formed from rings of lipid compounds, polymerised about the nanotubes, said polymerised compounds being obtained from lipid molecules with one or two chains A, bonded to a group Z where A is a chain, CH3—(CH2)m—C?C—C?C—(CH2)n—, where n and m, independently=whole numbers from 1 to 16 and Z is a polar head group embodied by a —COOH, —CO—NH—Y, —NH2 or N+(R)3, where R is an alkyl with C1, to C4 and Y is a —(CH2)4—C(R1)—N(CH2—COOH)2 group with R=H, or a COOH group, where A is a single lipid chain or a group of structure (I) or (II), where R2=a COOH, or —CO—NH—Y1 group with Y1=a —(CH2)4—C (R3)—N(CH2COOH)2 group with R3=H or a COOH group, where Z and R2 can also be neutral polar head groups of the sugar or polysaccharide type.
    Type: Application
    Filed: April 13, 2004
    Publication date: August 9, 2007
    Inventors: Charles Mioskowski, Stephane Rickling
  • Publication number: 20070049773
    Abstract: The invention concerns a method for functionalizing a phenolic compound bearing an electron-donor group, in said group para position, inter alia a method for the amidoalkylation of a phenolic compound bearing an electron-donor group, and more particularly, a phenolic compound bearing an electron-donor group preferably, in the hydroxyl group ortho position. The method for functionalizing in para position with respect to an electron-donor group carried by a phenolic compound is characterised in that the phenolic compound bearing an electron-donor group is subjected to the following steps: a first step which consists of protecting the hydroxyl group in the form of a sulphonic ester function; a second step which consists in reacting the protected phenolic compound with an electrophilic reagent; optionally, a third step deprotecting the hydroxyl group.
    Type: Application
    Filed: November 3, 2006
    Publication date: March 1, 2007
    Inventors: Charles Mioskowski, Alain Wagner, Nicolas Bensel, Virginie Pevere, Jean-Roger Desmurs
  • Publication number: 20070043240
    Abstract: The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids ? or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, R1 and R2 represent: a hydrogen atom; or either R1 or R2 represents a hydrogen atom and the other substituent is a radical Ra, an acyl group —CORa, such as acetyl, or a functional group —COORa, —SO2Ra, —N (Ra, Rb), Ra and Rb, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or R1 and R2 both represent a substituent as defined above. R3 represents a hydrogen atom or Ra and R4 has the significance of Ra.
    Type: Application
    Filed: May 7, 2004
    Publication date: February 22, 2007
    Inventors: Charles Mioskowski, Cedric Catala, Alain Wagner
  • Publication number: 20060205817
    Abstract: The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form.
    Type: Application
    Filed: December 1, 2003
    Publication date: September 14, 2006
    Inventors: Charles Mioskowski, Alain Wagner, Sandra De Lamo Marin, Cedric Catala, Jean-Michel Becht
  • Publication number: 20060199853
    Abstract: The invention relates to analogs of 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The analogs of the invention stimulate both glucose uptake and insulin secretion, and may thus be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.
    Type: Application
    Filed: February 17, 2006
    Publication date: September 7, 2006
    Inventors: Charles Mioskowski, Sandra Marin, Martine Maruani, Manjinder Gill
  • Publication number: 20060058475
    Abstract: The invention relates to polymers comprising a sequence of units comprising an ethylenic unsaturation, the unsaturation being located every 3 carbon atoms between two successive units. The invention also relates to processes for preparing such polymers.
    Type: Application
    Filed: October 10, 2003
    Publication date: March 16, 2006
    Inventors: Thierry Le Gall, Jean-Philippe Goddard, Charles Mioskowski
  • Publication number: 20050143453
    Abstract: An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 30, 2005
    Inventors: Michio Ishibashi, Alain Wagner, Charles Mioskowski, Catherine Sylvain
  • Patent number: 6878745
    Abstract: Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the induction of cytotoxic effecter macrophages which are induced into damaged organ tissues in response to chemokines or cytokines expressed depending on the type of the damaged organ tissues.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: April 12, 2005
    Inventors: Michio Ishibashi, Alain Wagner, Charles Mioskowski, Catherine Sylvain
  • Publication number: 20050020660
    Abstract: The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention_show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
    Type: Application
    Filed: September 23, 2002
    Publication date: January 27, 2005
    Inventors: Michel Guyaux, Chimmanamada Dinesh, Charles Mioskowski, Luc Quere, Jean-Philippe Starck, Patrice Talaga, Alain Wagner, Mateo Zanda
  • Publication number: 20030181506
    Abstract: An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.
    Type: Application
    Filed: December 12, 2002
    Publication date: September 25, 2003
    Inventors: Michio Ishibashi, Alain Wagner, Charles Mioskowski, Catherine Sylvain
  • Publication number: 20030092946
    Abstract: The invention concerns a method for functionalizing a phenolic compound bearing an electron-donor group, in said group para position, inter alia a method for the amidoalkylation of a phenolic compound bearing an electron-donor group, and more particularly, a phenolic compound bearing an electron-donor group preferably, in the hydroxyl group ortho position. The method for functionalizing in para position with respect to an electron-donor group carried by a phenolic compound is characterised in that the phenolic compound bearing an electron-donor group is subjected to the following steps: a first step which consists of protecting the hydroxyl group in the form of a sulphonic ester function; a second step which consists in reacting the protected phenolic compound with an electrophilic reagent; optionally, a third step deprotecting the hydroxyl group.
    Type: Application
    Filed: October 2, 2002
    Publication date: May 15, 2003
    Inventors: Charles Mioskowski, Alain Wagner, Nicolas Bensel, Virginie Pevere, Jean-Roger Desmurs