Patents by Inventor Charles Montgomery
Charles Montgomery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240383870Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a disclosed compound or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 1, 2022Publication date: November 21, 2024Inventors: Adam BROCKMAN, Stephen Gitu MACHATHA, Charles MONTGOMERY
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Patent number: 12098132Abstract: The present invention relates to methods for synthesizing compounds, and to intermediates thereto, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis.Type: GrantFiled: May 2, 2020Date of Patent: September 24, 2024Assignee: Aldeyra Therapeutics, Inc.Inventors: Stephen Gitu Machatha, Charles Montgomery
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Patent number: 12029735Abstract: The present invention relates to free-base and salt forms, and compositions thereof of small molecule therapeutics acting as a scavenger for toxic aldehydes. The present invention further relates to use of the free-base and salt forms, and compositions thereof for treating diseases, disorders, or conditions in which aldehyde toxicity is implicated in their pathogenesis.Type: GrantFiled: May 28, 2021Date of Patent: July 9, 2024Assignee: Aldeyra Therapeutics, Inc.Inventors: Stephen Gitu Machatha, Charles Montgomery, Steven Krausert, Jonathan James Loughrey, Hannah Ruth McLachlan, Gregor Sneddon
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Publication number: 20220089542Abstract: The present invention relates to methods for synthesizing compounds, and to intermediates thereto, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis.Type: ApplicationFiled: May 2, 2020Publication date: March 24, 2022Inventors: Stephen Gitu MACHATHA, Charles MONTGOMERY
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Publication number: 20210393612Abstract: The present invention relates to free-base and salt forms, and compositions thereof of small molecule therapeutics acting as a scavenger for toxic aldehydes. The present invention further relates to use of the free-base and salt forms, and compositions thereof for treating diseases, disorders, or conditions in which aldehyde toxicity is implicated in their pathogenesis.Type: ApplicationFiled: May 28, 2021Publication date: December 23, 2021Inventors: Stephen Gitu MACHATHA, Charles MONTGOMERY, Steven KRAUSERT, Jonathan James LOUGHREY, Hannah Ruth MCLACHLAN, Gregor SNEDDON
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Patent number: 8703671Abstract: The invention provides for a process for preparing a urea grease including: (a) introducing a first feed component to a first feeding zone; (b) introducing a second feed component to a second feeding zone; (c) first reacting-mixing in a first reacting-mixing zone; and (d) cooling-mixing in a cooling-mixing zone. The invention also provides for a process for preparing a urea grease including: (a) introducing a first feed component to a first feeding zone; (b) introducing a second feed component to a second feeding zone; (c) first reacting-mixing in a first reacting-mixing zone; (d) introducing a third feed component to a third feeding zone; (e) second reacting-mixing in a second reacting-mixing zone; and (f) cooling-mixing in a cooling-mixing zone. The invention also provides for an apparatus for preparing a urea grease comprising: (a) a first feeding zone; (b) a second feeding zone; (c) a first reacting-mixing zone; and (d) a cooling-mixing zone.Type: GrantFiled: December 5, 2007Date of Patent: April 22, 2014Assignee: Shell Oil CompanyInventors: Jean-luc Pierre André Brossaud, David Edmund Code, Jerome Dabos, Ronald David Harris, Charles Montgomery Harris, Aimin Huang, Krishna Rangraj Kaushik, Catherine Maillard, Howard Brian Mead, Raghunath Gopal Menon, Jean-paul Saint
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Patent number: 8617372Abstract: An array-type sensor that senses NH3 includes non-Nernstian sensing elements constructed from metal and/or metal-oxide electrodes on an O2 ion conducting substrate. In one example sensor, one electrode may be made of platinum, another electrode may be made of manganese (III) oxide (Mn2O3), and another electrode may be made of tungsten trioxide (WO3). Some sensing elements may further include an electrode made of La0.6Sr0.4Co0.2Fe0.8O3 and another electrode made of LaCr0.95Mg0.05O3.Type: GrantFiled: March 11, 2011Date of Patent: December 31, 2013Assignee: UT-Battelle, LLCInventors: David Lawrence West, Frederick Charles Montgomery, Timothy R. Armstrong, Robert J. Warmack
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Publication number: 20120272341Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.Type: ApplicationFiled: May 16, 2012Publication date: October 25, 2012Inventors: Katherin E. Combs, Ling Ling Culbertson, Juan Delmas-Mata, Frederic de Sauvage, Liangfen Fan, Gretchen Frantz, Leslie Jane Green, Erin Marie Massey, Dina Rebecca McLain, Charles Montgomery, Bobby Joe Payne, Franklin Peale, Heidi Phillips, Michelle Rohrer, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Ching-Yun Wang, Wen Xiong, Peter Vogel
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Publication number: 20120228138Abstract: An array-type sensor that senses NH3 includes non-Nernstian sensing elements constructed from metal and/or metal-oxide electrodes on an O2 ion conducting substrate. In one example sensor, one electrode may be made of platinum, another electrode may be made of manganese (III) oxide (Mn2O3), and another electrode may be made of tungsten trioxide (WO3). Some sensing elements may further include an electrode made of La0.6Sr0.4Co0.2Fe0.8O3 and another electrode made of LaCr0.95Mg0.05O3.Type: ApplicationFiled: March 11, 2011Publication date: September 13, 2012Inventors: David Lawrence West, Frederick Charles Montgomery, Timothy R. Armstrong, Robert J. Warmack
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Publication number: 20120210450Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes.Type: ApplicationFiled: April 8, 2011Publication date: August 16, 2012Inventors: Fred de Sauvage, Dorothy French, Lino Gonzalez, Asja Praetor, Weilan Ye, Katherin E. Combs, Zhiyong Ding, Allison Anne Byers Horner, Erin Marie Massey, Charles Montgomery, Laurie Jeanette Minze, Carolina Rangel, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Peter Vogel
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Patent number: 8227661Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.Type: GrantFiled: October 19, 2010Date of Patent: July 24, 2012Assignee: Lexicon Genetics, Inc.Inventors: Joel A. Edwards, Wenhu Huang, Charles Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Oox
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Publication number: 20120030776Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes.Type: ApplicationFiled: October 22, 2010Publication date: February 2, 2012Inventors: Katherin E. Combs, Ling Ling Culbertson, Frederic de Sauvage, Zhiyong Ding, Joel Edwards, Rosemary Girgis, Allison Anne Byers Horner, Harald Junge, Jagath Reddy Junutula, Erin Marie Massey, Dina Rebecca McLain, Charles Montgomery, Bobby Joe Payne, Heidi Phillips, Ni Nancy Qian, Carolina Rangel, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Peter Vogel, Weilan Ye
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Publication number: 20120005766Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes.Type: ApplicationFiled: August 9, 2011Publication date: January 5, 2012Inventors: Kristi Rae Bollinger, Katherin E. Combs, Jaime-Jo Cunningham, Ling Ling Culbertson, Frederic J. de Sauvage, Joel Edwards, Leslie Jane Green, Rosemary Girgis, Allison Anne Byers Horner, Dina Rebecca McLain, Charles Montgomery, Laurie Jeanette Minze, Bobby Joe Payne, Heidi Phillips, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Teresa Gail Townsend, Peter Vogel
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Publication number: 20110191865Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.Type: ApplicationFiled: June 3, 2009Publication date: August 4, 2011Applicants: Genentech, Inc., Lexicon Genetics IncorporatedInventors: Joel A. Edwards, Wenhu Huang, Charles A. Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Westbrook
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Publication number: 20110182883Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes.Type: ApplicationFiled: March 3, 2011Publication date: July 28, 2011Inventors: Katherin E. Combs, Frederic de Sauvage, Liangfen Fan, Ellen Filvaroff, Allison Anne Byers Horner, Bryan Irving, Jagath Reddy Junutula, Erin Marie Massey, Dina Rebecca Mclain, Laurie Jeanette Minze, Charles Montgomery, Bobby Joe Payne, Heidi Phillips, Carolina Rangel, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Teresa Gail Townsend, Peter Vogel
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Publication number: 20110173708Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.Type: ApplicationFiled: February 18, 2011Publication date: July 14, 2011Inventors: Katherin E. Combs, Ling Ling Culbertson, Juan Delmas-Mata, Frederic de Sauvage, Liangfen Fan, Gretchen Frantz, Leslie Jane Green, Erin Marie Massey, Dina Rebecca McLain, Charles Montgomery, Bobby Joe Payne, Franklin Peale, Heidi Phillips, Michelle Rohrer, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Ching-Yun Wang, Wen Xiong, Peter Vogel
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Patent number: 7956237Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.Type: GrantFiled: August 23, 2005Date of Patent: June 7, 2011Assignee: Genentech, Inc.Inventors: Charles Montgomery, Zheng-Zheng Shi, Mary Jean Sparks
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Publication number: 20110097330Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes.Type: ApplicationFiled: February 27, 2006Publication date: April 28, 2011Applicants: Genentech, Inc., Lexicon Pharmaceuticals, Inc.Inventors: Allison Anne Byers Horner, Catherine Batac Clarke, Katherin E. Combs, Frederic J. de Sauvage, Joel Edwards, Paul Godowski, Deanna Grant Wilson, Wenhu Huang, Lorelei Diane Ketcherside, Erin Marie Massey, Charles Montgomery, Bobby Joe Payne, Andrew Peterson, Ni Nancy Qian, Jeffrey J. Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Colleen M. Viator, Peter Vogel, Weilan Ye, Jung-Hua Yeh, Zhiyong Ding
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Patent number: 7931902Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.Type: GrantFiled: July 18, 2006Date of Patent: April 26, 2011Assignee: Genentech, Inc.Inventors: Frederic J. de Sauvage, Gretchen Frantz, Charles Montgomery, Franklin Peale, Zheng-Zheng Shi, Mary Jean Sparks
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Publication number: 20110093960Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.Type: ApplicationFiled: October 19, 2010Publication date: April 21, 2011Inventors: Joel A. Edwards, Wenhu Huang, Charles Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Oox