Abstract: A decoupler 10 having a rotatable input member 12 for coupling to a drive unit 13 and a rotatable output member 28 for coupling to an output drive, and a gear set 34 for transmitting drive from the rotatable input member 12 to the rotatable output member 28, wherein the decoupler 10 is operable to selectively isolate an input gear 36 of the gear set 34 from driving connection with the drive unit 13, and to selectively engage the input gear 36 into driving connection with the drive unit 13. The invention also relates to a method of transmitting torque and to a method of installing the decoupler 10.

Abstract: A drive system (10) including an internal combustion engine (12), a planetary gear-set (16), an electric motor (18) and a transmission (20), wherein the internal combustion engine (12) and the electric motor (18) each drive the transmission (20) via the planetary gear set (16), and the electric motor (18) drives a fluid pump (22) of the transmission (20). In a further embodiment there is disclosed a fluid pump for pumping fluid from a source to a destination, wherein first and second inlet conduits are provided between the source and the pump, first and second outlet conduits are provided between the pump and the destination, and each of the conduits is provided with a valve allowing fluid flow through the conduit in only one direction, such that when the fluid pump is rotated in a first direction fluid is pumped through the first inlet and outlet conduits, and when the fluid pump is rotated in a second opposite direction fluid is pumped though the second inlet and outlet conduits.

Abstract: A compound of Formula (I): or a pharmaceutically and/or veterinarily acceptable derivative thereof, wherein R1, R2, R3, R4, R5, and R8 are as defined above.

Abstract: This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

Abstract: This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

Abstract: This invention relates to a compound of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R1 to R5 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation, compositions containing them and the uses of such derivatives. The compounds of the present invention inhibit the interaction of gp120 with CD4 and are therefore of use in the treatment of HIV, a retroviral infection genetically related to HIV, or AIDS.

Abstract: This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4, n W, X and Y are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).