Patents by Inventor Charles N. Moorefield
Charles N. Moorefield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100001235Abstract: The invention is directed to quantum dot nanoparticles and methods of preparation. Using regioselective dendritic functionalized cellulose, quantum dots may be embedded in the modified cellulosic material. The quantum dot nanoparticles provide use for biotechnology or biomedicinal applications. Photooptical properties and morphology for use in as well as its biocompatibility were investigated.Type: ApplicationFiled: May 23, 2007Publication date: January 7, 2010Applicant: THE UNIVERSITY OF AKRONInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 7589229Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2?CHCO2— TBu by nucleophilic addition to form the triester nitrotrialkanoate of the formula and then reducing the nitrosubstituent to afford the said amine monomer.Type: GrantFiled: January 26, 2007Date of Patent: September 15, 2009Assignee: The University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Rajani K. Behera
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Publication number: 20090171088Abstract: In accordance with the present invention, there is provided a method for preparing a reversible, self-assembly of an imbedded hexameric metallomacrocycle within a macromolecular superstructure. The method occurs by an intramolecular mechanism in which a macromolecular skeleton possesses multiple ligands capable of reversible assembly-disassembly triggered by the presence of metal ions.Type: ApplicationFiled: November 23, 2005Publication date: July 2, 2009Applicant: THE UNIVERSITY OF AKRONInventors: George R. Newkome, Charles N. Moorefield, Pingshan Wang
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Publication number: 20090131656Abstract: The invention relates to the formation of synthesized fractal constructs and the methods of chemical self-assembly for the preparation of a non-dendritic, nano-scale, fractal constructs or molecules. More particularly, the invention relates to fractal constructs formed by molecular self-assembly, to create synthetic, nanometer-scale fractal shapes. In an embodiment, a nanoscale Sierpinski hexagonal gasket is formed. This non-dendritic, perfectly self-similar fractal macromolecule is comprised of bisterpyridine building blocks that are bound together by coordination to 36 Ru and 6 Fe ions to form a nearly planar array of increasingly larger hexagons around a hollow center.Type: ApplicationFiled: May 10, 2007Publication date: May 21, 2009Inventors: George R. Newkome, Charles N. Moorefield
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Patent number: 7368512Abstract: A method of detecting unreacted termini within a dendritic structure is achieved by exposing a dendrimer to a single generating compound capable of bonding to and tagging a deprotected but uncoupled termini. A signal generated by the signal generating compound to an otherwise uncoupled termini provides detection of the unreacted termini.Type: GrantFiled: September 14, 2004Date of Patent: May 6, 2008Assignee: University of South FloridaInventors: George Newkome, Charles N. Moorefield, Claus Weis
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Patent number: 7183426Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2?CHCO2-TBu by nucleophilic addition to form the triester nitrotrialkanoate of the formula and then reducing the nitrosubstituent to afford the said amine monomer.Type: GrantFiled: June 16, 2003Date of Patent: February 27, 2007Inventors: George R. Newkome, Charles N. Moorefield, Rajani K. Behera
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Publication number: 20030097019Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula 1Type: ApplicationFiled: August 29, 1996Publication date: May 22, 2003Inventors: GEORGE R. NEWKOME, CHARLES N. MOOREFIELD
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Patent number: 6566409Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a “key” unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: May 8, 2000Date of Patent: May 20, 2003Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
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Patent number: 6399717Abstract: There is provided dendritic materials for enhanced performance of an energy storage device having a unimolecular micelle including branched building blocks. Also provided is an energy storage device having a lithium source, a hydrocarbon dendrimer based electrolyte made up of a unimolecular micelle including branched building blocks, insertional electrode, and a current conductor.Type: GrantFiled: November 22, 2000Date of Patent: June 4, 2002Assignee: The University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 6130209Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: April 24, 1998Date of Patent: October 10, 2000Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
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Patent number: 5886126Abstract: The method of forming a surface layer on a substrate is accomplished by dendrimerizing a mixture of branched monomers on the substrate surface wherein the monomers have heterogeneous functionalized branches and homogenous connectivity to the substrate. A cascade polymer coated substrate is formed consisting essentially of a substrate including a surface and at least one dendrimerized surface layer consisting of heterogeneous functionalities the layer being linked to the substrate by homogenous linkages, preferably isocyanate linkages.Type: GrantFiled: August 28, 1996Date of Patent: March 23, 1999Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5886127Abstract: The method of forming a surface layer on a substrate is accomplished by dendrimerizing a mixture of branched monomers on the substrate surface wherein the monomers introduce heterogeneous functionalized branches and homogenous connectivity to the substrate. A cascade polymer coated substrate is formed consisting essentially of a substrate including a surface and at least one dendrimerized surface layer consisting of heterogeneous functionalities the layer being linked to the substrate by homogenous linkages, preferably isocyanate linkages.Type: GrantFiled: November 19, 1997Date of Patent: March 23, 1999Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5863919Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: August 28, 1996Date of Patent: January 26, 1999Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
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Patent number: 5650101Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: July 25, 1994Date of Patent: July 22, 1997Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory R. Baker
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Patent number: 5585457Abstract: Unimolecular micelies, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Each of the branches define a flexible arm from a central core atom and terminate with a hydrodynamic reactive group. A method is described for manipulating such cascade polymers.Type: GrantFiled: June 5, 1995Date of Patent: December 17, 1996Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5516810Abstract: Unimolecular micelles, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Reactive sites located on the framework and hence within the void regions are capable of being chemically transformed to allow covalent and noncovalent incorporation of one or more guest species into the said void regions. Further, a method is described for making such cascade polymers that includes the steps of forming a unimolecular micelle containing internal void areas with accessible reactive sites capable of bonding to at least one guest after construction of the said unimolecular micelle. The guests are contained within the internal void volume of the cascade polymer and are available and accessible for additional chemical modification.Type: GrantFiled: February 14, 1994Date of Patent: May 14, 1996Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5422379Abstract: Unimolecular micelles, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Each of the branches define a flexible arm from a central core atom and terminate with a hydrodynamic reactive group. A method is described for manipulating such cascade polymers.Type: GrantFiled: April 12, 1994Date of Patent: June 6, 1995Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5376690Abstract: Unimolecular micelles, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Reactive sites located on the framework and hence within the void regions are capable of being chemically transformed to allow covalent and noncovalent incorporation of one or more guest species into the said void regions. Further, a method is described for making such cascade polymers that includes the steps of forming a unimolecular micelle containing internal void areas with accessible reactive sites capable of bonding to at least one guest after construction of the said unimolecular micelle. The guests are contained within the internal void volume of the cascade polymer and are available and accessible for additional chemical modification.Type: GrantFiled: September 7, 1993Date of Patent: December 27, 1994Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5210309Abstract: The bis-homotris compounds 4-amino-4-[1-(3-hydroxy-propyl)]-1,7-heptanediol and 4-[1-(3-aminopropyl)]-4-[1-(3-hydroxypropyl)]-1, 7-heptanediol, and organic synthetic methods for their preparation are described. Unique multifunctional aminotriols, as well as their percursors, quaternary nitroalkanes are disclosed as building blocks for unimolecular micelles, as well as new series of cascade polymers. The quaternary nitro compounds which are disclosed allow the synthesis of a new aminotriol containing a quaternary carbon.Type: GrantFiled: March 9, 1992Date of Patent: May 11, 1993Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5206410Abstract: The bis-homotris compounds 4-amino-4-[1-(3-hydroxypropyl)]-1,7-heptanediol and 4-[1-(3-aminopropyl)]-4-[1-(3-hydroxypropyl)]-1, 7-heptanediol, and organic synthetic methods for their preparation are described. Unique multifunctional aminotriols, as well as their percursors, quaternary nitroalkanes are disclosed as building blocks for unimolecular micelles, as well as new series of cascade polymers. The quaternary nitro compounds which are disclosed allow the synthesis of a new aminotriol containing a quaternary carbon.Type: GrantFiled: April 14, 1992Date of Patent: April 27, 1993Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield