Abstract: Pediatric liver cancers (PLC) are rare tumors. In particular, hepatoblastomas are usually treated with cisplatin-based neoadjuvant chemotherapy followed by surgical removal of the tumor and adjuvant chemotherapy. However, some hepatoblastomas develop resistance to chemotherapy during the initial neoadjuvant chemotherapy or after tumor recurrence, and the molecular determinants of cisplatin resistance are yet to be discovered. In contrast to hepatoblastomas, pediatric HCCs respond poorly to chemotherapy, and as in adults, they have a poor prognosis if not completely removed by surgery. There is thus an urgent need for new therapeutic strategies to overcome this resistance. Now the inventors demonstrate that Elimusertib and Cisplatin combination shows synergistic efficacy on tumor cell viability inhibition in pediatric liver cancer cell lines. The present invention thus relates to the combination of cisplatin and Elimusertib for the treatment of pediatric liver cancers.

Abstract: Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. The aimed of the inventors was to characterize the natural history of AAV infection in the liver. Viral DNA was thus quantified in tumor and non-tumor liver tissues of 1461 patients. Presence of episomal form and viral mRNA expression were analyzed using a DNAse/TaqMan based assay and quantitative RT-PCR. In silico analyses using viral capture data explored viral variants and new clonal insertions. AAV DNA was detected in 21% of the patients equally distributed in 2 major viral subtypes: one similar to AAV2, the other hybrid between AAV2 and AAV13 sequences. Thus the inventors provided an integrated analysis of the wild type AAV infection in the liver with the identification of viral genotypes, molecular forms, helper virus relationship and viral integrations.

Abstract: A system and a method are provided for sampling and analyzing organic material, including soil, fertilizer, manure and leaves. A sample container having porous sidewalls and a unique identifier is provided. A geographic position corresponding to a location where a sample was taken is associated with the unique identifier. The sample container with the sample contained therein is received, and the sample is compacted while inside the sample container. The sample is analyzed while inside the sample container using a Laser Induced Breakdown Spectroscopy (LIBS) system and analysis results are generated. The analysis results of the sample are associated with the unique identifier of the sample container.

Abstract: A system and a method are provided for sampling and analyzing organic material, including soil, fertilizer, manure and leaves. A sample container having porous sidewalls and a unique identifier is provided. A geographic position corresponding to a location where a sample was taken is associated with the unique identifier. The sample container with the sample contained therein is received, and the sample is compacted while inside the sample container. The sample is analyzed while inside the sample container using a Laser Induced Breakdown Spectroscopy (LIBS) system and analysis results are generated. The analysis results of the sample are associated with the unique identifier of the sample container.

Abstract: A system and a method are provided for sampling and analyzing organic material, including soil, fertilizer, manure and leaves. A sample container having porous sidewalls and a unique identifier is provided. A geographic position corresponding to a location where a sample was taken is associated with the unique identifier. The sample container with the sample contained therein is received, and the sample is compacted while inside the sample container. The sample is analyzed while inside the sample container using a Laser Induced Breakdown Spectroscopy (LIBS) system and analysis results are generated. The analysis results of the sample are associated with the unique identifier of the sample container.

Abstract: A system and a method are provided for sampling and analyzing organic material, including soil, fertilizer, manure and leaves. A sample container having porous sidewalls and a unique identifier is provided. A geographic position corresponding to a location where a sample was taken is associated with the unique identifier. The sample container with the sample contained therein is received, and the sample is compacted while inside the sample container. The sample is analyzed while inside the sample container using a Laser Induced Breakdown Spectroscopy (LIBS) system and analysis results are generated. The analysis results of the sample are associated with the unique identifier of the sample container.

Abstract: The present invention relates to the technical field of liver diseases, their classification and diagnosis. It provides a new method for classifying a liver sample between non-hepatocellular sample; hepatocellular carcinoma (HCC) sample with further classification into one of subgroups G1 to G6; focal nodule dysplasia (FNH) sample; hepatocellular adenoma (HCA) sample with further classification into HNF1A mutated HCA, inflammatory HCA, ? catenin mutated HCA or other HCA sample; and other benign liver sample, based on determination in vitro of genes expression profiles and analysis of the expression profile using algorithms calibrated with reference samples. The invention also provides kits for the classification of liver samples, and methods of treatment of liver disease in a subject based on a preliminary classification of a liver sample of said subject.

Abstract: The present invention relates to the technical field of hepatocellular carcinoma (HCC) management, and more precisely to the prognosis of HCC aggressiveness and associated therapeutic decisions. The invention provides a new prognosis method of HCC aggressiveness, based on determination in vitro and analysis of an expression profile comprising genes TAF9, RAMP3, HN1, KRT19, and RAN. The invention also provides kits for the prognosis of HCC aggressiveness, and methods of treatment of HCC in a subject based on a preliminary prognosis of said subject HCC aggressiveness.