Abstract: Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

Abstract: An automotive headlight is disclosed including: an optical unit including a plurality of optical elements, each optical element having a different central direction; a segmented light-emitting diode (LED) chip including a plurality of LEDs that are separated by trenches formed on the segmented LED chip and arranged in a plurality of sections, each section being aligned with a different respective optical element, and each section including at least one first LED and at least one second LED; and a controller configured to: apply a forward bias to each of the first LEDs, apply a reverse bias to each of the second LEDs, and change a brightness of the first LEDs in any section based on a signal generated by the second LED in that section.

Abstract: A method at an electronic device with a display includes: displaying a user interface having a first region and a second region; receiving, and displaying in the first region of the user interface, a live video stream of a physical environment captured by a remote video camera; displaying, in the second region, a timeline corresponding to a timespan for a first portion of a duration during which the live video stream may have been recorded; in response to receiving a user interaction to move the timespan to a second portion of the duration, transitioning the displayed timeline to a new timeline that corresponds to the timespan for the second portion, and while transitioning, displaying, in the first region, a subset of video frames representing the first and/or second portion of the duration.

Abstract: Drying implements disclosed herein can provide a minimal, collapsible, dish drying pad encased in woven, silicone protection for recently washed kitchenware placed thereon. Such drying implements include a rapid absorption and drying diatomaceous earth panels that causes drain water to rapidly dissipate. This helps to prevent bacteria growth, by eliminating the moist environment where mold thrives. The mesh silicone layer or encasing keeps dishes protected and the kitchen looking fresh and modern. The drying implement shows various improvements for all types of drying jobs from dishes to produce. The drying implement folds upon its connected sections for smaller jobs and for easy storage when not in use.

Abstract: The disclosure relates to a lubricating composition consisting essentially of a decarboxylated rosin acid (DCR), a base oil, and optional additives, and methods for using same. The decarboxylated rosin acid has a density of 0.9 to 1.0 g/cm3 at 20° C., a viscosity of 15 to 60 cSt at 40° C., and an acid value of <50 mg KOH/g. The lubricating compositions containing the DCR is characterized as having improved anti-wear and friction reducing properties, as well as improved electrical properties, and cooling performance for use in electric and hybrid vehicles. In embodiments, the lubricating composition exhibits a wear scar diameter of <350 ?m, according to ASTM D6079.

Abstract: The disclosure relates to fuel compositions comprising a base fuel, a lubricity modifier, and optional additives, and methods for using same. The base fuel is a middle distillate having a sulfur content of <500 ppm. The lubricity modifier comprises a plant-derived liquid decarboxylated rosin acid and optionally at least one of a fatty acid, a fatty acid derivative, and mixtures thereof. The decarboxylated rosin acid has a flash point of 95-180° C., a density of 0.9 to 1.0 g/cm3 at 20° C., a viscosity of 15 to 60 cSt at 40° C., and an acid value of <50 mg KOH/g. The fuel compositions have desired tribological properties, such as wear scar diameter, coefficient of friction, and percent film, as well as cloud point performance.

Abstract: A medical device may include an elongated body having a distal elongated body portion and a central longitudinal axis. The medical device may include a balloon positioned along the distal elongated body portion. The balloon may be configured to receive a fluid to inflate the balloon such that an exterior balloon surface contacts a calcified lesion within a patient's vasculature. The medical device may include one or more pressure wave emitters positioned along the central longitudinal axis of the elongated body. The one or more pressure wave emitters may be configured to propagate at least one pressure wave through the fluid to fragment the calcified lesion. At least one pressure wave emitter may include an optical fiber configured to transmit laser energy into the balloon. The laser energy may be configured to create a cavitation bubble in the fluid.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing cell images using neural networks. One of the methods includes obtaining data comprising an input image of one or more biological cells illuminated with an optical microscopy technique; processing the data using a stained cell neural network; and processing the one or more stained cell images using a cell characteristic neural network, wherein the cell characteristic neural network has been configured through training to receive the one or more stained cell images and to process the one or more stained cell images to generate a cell characteristic output that characterizes features of the biological cells that are stained in the one or more stained cell images.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.

Abstract: The present invention provides isolated proteins isolatable from a Pasteurella spp. such as P. multocida. Also provided by the present invention are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.

Abstract: The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

Abstract: A system and method for storing, shipping, preserving and ripening produce. Packaging of respiring produce, particularly avocados, in sealed tray systems. The tray systems include a lower bowl-shaped tray having an upper lip to which a flexible film is adhered. The flexible film has an aperture covered by a breathable membrane. The film permits passage of water vapor to reduce the chance of mold formation during packaging and shipping. The breathable membrane controls gaseous exchange at different temperatures and has pores that open above the threshold temperature. The breathable membrane alters the O2 and CO2 within the tray above the threshold temperature, thus slowing up the ripening process at elevated temperatures.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing fundus images using fundus image processing machine learning models. One of the methods includes obtaining a model input comprising one or more fundus images, each fundus image being an image of a fundus of an eye of a patient; processing the model input using a fundus image processing machine learning model, wherein the fundus image processing machine learning model is configured to process the model input comprising the one or more fundus image to generate a model output; and processing the model output to generate health analysis data.

Abstract: The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

Abstract: A modular service interface is provided. The modular service interface includes separable first and second halves, one or more alignment features, a connector interface and one or more electropermanent magnet modules, connector interface configured to mate the first and second halves when activated and allow the first and second halves to be separated when inactivated. The modular service interface includes no mechanical actuators to retain the first half to the second half.

Abstract: The present invention provides isolated proteins isolatable from a Pasteurella spp. such as P. multocida. Also provided by the present invention are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.

Abstract: A faucet including a faucet head, a body and a magnetic coupling releasably coupling the faucet head to the faucet body.

Abstract: A faucet including a spring spout supporting a spout nest, and a sprayhead releasably coupled to the spout nest. A docking cradle is supported by the spout base and is configured to releasably couple to the spout nest. The faucet may include a capacitive sensor operably coupled to the spring spout by at least one capacitive coupling.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.