Patents by Inventor Charles Orella

Charles Orella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of carbapenem antibiotics and methods of preparation
    Patent number: 7145002
    Abstract: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than ?5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between ?5 and ?25° C.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: December 5, 2006
    Assignee: Merck & Co. Inc.
    Inventors: Karel M. J. Brands, Raymond Cvetovich, Louis S. Crocker, Michael D. Ward, Amar J. Mahajan, Robert M. Wenslow, John M. Williams, Daniel R. Sidler, Charles Orella, Elizabeth S. Fisher, Ronald Jobson
  • Crystalline forms of ertapenem sodium
    Publication number: 20040235817
    Abstract: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: 1
    Type: Application
    Filed: January 27, 2004
    Publication date: November 25, 2004
    Inventors: Karel M. J. Brands, Raymond Cvetovich, Louis S Crocker, Michael D Ward, Amar J Mahajan, Robert M Wenslow, John M Williams, Daniel R Sidler, Charles Orella, Elizabeth S Fisher
  • Crystalline forms of carbapenem antibiotics and methods of preparation
    Patent number: RE40794
    Abstract: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than ?5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between ?5 and ?25° C.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: June 23, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Karel M. J. Brands, Raymond Cvetovich, Louis S. Crocker, Michael D. Ward, Amar J. Mahajan, Robert M. Wenslow, John M. Williams, Daniel R. Sidler, Charles Orella, Elizabeth S. Fisher, Ronald Jobson