Patents by Inventor Charles Pigerol
Charles Pigerol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4139634Abstract: Indole derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl radical, R.sub.2 and R.sub.3, which are the same or different, each represent a hydrogen atom, a methyl or ethyl radical, a benzyl radical or represent together a pentamethylene, hexamethylene, oxydiethylene or N-methylaminodiethylene chain, forming thus a cycle with the nitrogen atom, R.sub.4 represents a phenyl, 2', 4'-dimethyl-phenyl, isopropyl, cyclopropyl, 1-methyl-cyclopropyl, cyclopentyl or cyclohexyl radical, R.sub.5 represents a hydrogen atom, a branched- or straight-chain alkyl radical containing from 1 to 3 carbon atoms, a methylthio or ethylthio radical or a straight-chain acyl radical containing from 2 to 6 carbon atoms, R.sub.6 represents a hydrogen atom or a halogen atom, a methyl, methoxy, hydroxy, carboxy, nitro, amino, methylamino or dimethylamino radical, R.sub.7 represents a hydrogen atom or a halogen atom and n is 1 or 2, with the proviso that two at least of the groups R.sub.5, R.sub.Type: GrantFiled: May 20, 1977Date of Patent: February 13, 1979Assignee: LabazInventors: Charles Pigerol, Paul DE Cointet de Fillain, Pierre Eymard, Jean-Pierre Werbenec, Madeleine Broll
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Patent number: 4134909Abstract: The invention relates to new compounds of the general formula : ##STR1## wherein X represents a hydrogen or halogen atom, R.sub.1 and R.sub.2, which are the same or different, each represent a hydrogen atom or a methoxy radical and R.sub.3 represents an alkyl or aryl radical, with the proviso that at least one of the substituents R.sub.1 and R.sub.2 is not a hydrogen atom.The compounds of formula I are useful for preparing stabilizers for thermoplastic resins.Type: GrantFiled: June 29, 1977Date of Patent: January 16, 1979Assignee: LabazInventors: Charles Pigerol, Paul DE Cointet de Fillain, Yves Bazile, Michel Chignac, Claude Grain
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Patent number: 4129572Abstract: 2-Phenyl-indole derivatives of the general formula: ##STR1## wherein R.sub.1 represents a hydroxy radical, a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms, an allyloxy or propargyloxy radical, a cylcoalkyloxy radical containing from 5 to 7 carbon atoms or a benzyloxy radical, R.sub.2 represents a hydroxy radical, an ethoxy, methylsulphonyloxy, benzenesulphonyloxy or toluenesulphonyloxy group and R.sub.3 represents a hydrogen atom, a hydroxy radical or a methoxy group. The said 2-phenyl-indole derivatives are useful in particular as stabilizers of polymers and co-polymers of vinyl chloride.Type: GrantFiled: July 1, 1977Date of Patent: December 12, 1978Assignee: LabazInventors: Charles Pigerol, Paul DE Cointet de Fillain, Yves Bazile
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Patent number: 4127607Abstract: Process for preparing di-n-propyl acetamide of the formula: ##STR1## whereby di-n-propyl acetonitrile is hydrolyzed by means of 80% sulphuric acid aqueous solution in the proportion of 2 to 2.5 g of dilute acid/g of nitrile, at a temperature between 80.degree. C and 130.degree. C to obtain the desired amide.Type: GrantFiled: May 25, 1977Date of Patent: November 28, 1978Assignee: LabazInventors: Michel Chignac, Claude Grain, Charles Pigerol
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Patent number: 4127604Abstract: Process for the preparation of di-n-propyl acetic acid of formula: ##STR1## and its non-toxic alkali and alkaline earth metal salts whereby in a single stage, sodium n-propylate in n-propanol medium is added to a reaction medium formed of a cyanacetic ester of general formula: ##STR2## in which R represents an alkyl radical having from 1 to 4 carbon atoms, and n-propyl bromide or iodide, the alkylation reaction taking place under reflux, the crude ester obtained is saponified with a 10 to 20% solution of sodium or potassium hydroxide, the salt thus obtained is acidified with a strong acid, to give the crude di-n-propyl cyanacetic acid, which is decarboxylated by heating at a temperature between 140.degree. and 190.degree. C, to provide the di-n-propyl acetonitrile, the di-n-propyl acetonitrile obtained is hydrolysed by means of an aqueous solution of 75 to 80% sulphuric acid at a temperature of 80.degree.-140.degree.Type: GrantFiled: May 25, 1977Date of Patent: November 28, 1978Assignee: LabazInventors: Michel Chignac, Claude Grain, Charles Pigerol
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Patent number: 4115401Abstract: Prostaglandin derivatives corresponding to the general formula: ##STR1## wherein R.sub.1 represents hydrogen, methyl or ethyl, R.sub.2, R.sub.3 and R.sub.4, which are the same or different, each represent hydrogen or methyl and R is selected from the groups consisting of: ##STR2## in which R.sub.5 represents hydrogen, methyl or ethyl, R.sub.6 represents methyl, ethyl or acetyl and R.sub.7 and R.sub.8, when they are different, each represent hydrogen or a branched- or straight-chain alkyl group having from 1 to 7 carbon atoms or R.sub.7 and R.sub.8, when they are identical, each represent hydrogen or a straight-chain alkyl group having from 1 to 3 carbon atoms with the provisos that:When both R.sub.7 and R.sub.8 represent hydrogen, R.sub.5 is methyl or ethyl,When R.sub.5 represents methyl and R.sub.2, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 all represent hydrogen then R.sub.1 is ethyl,The said prostaglandin derivatives being in the form of a mixture of isomers or of an individual isomer.Type: GrantFiled: March 31, 1977Date of Patent: September 19, 1978Assignee: LabazInventors: Souli Nanthavong, Charles Pigerol, Pierre Eymard, Jacques Simiand
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Patent number: 4113736Abstract: The present invention relates to new stabilizers of polymers and co-polymers of vinyl chloride corresponding to the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6, which are the same or different, represent:R.sub.1 = a hydrogen atom or a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms,R.sub.2 = a hydrogen atom, a branched-or straight-chain alkyl group containing from 1 to 3 carbon atoms or a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms,R.sub.3 and R.sub.5 = a hydrogen atom, a hydroxy group, a branched- or straight-chain alkyl group containing from 1 to 3 carbon atoms or a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms,R.sub.4 = a hydrogen atom, a hydroxy group, a branched- or straight-chain alkyl group containing from 1 to 3 carbon atoms or a branched- or straight-chain alkyloxy group containing from 2 to 12 carbon atoms,R.sub.Type: GrantFiled: March 17, 1976Date of Patent: September 12, 1978Assignee: S. A. LabazInventors: Charles Pigerol, Paul DE Cointet de Fillain, Souli Nanthavong
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Patent number: 4108865Abstract: Thiophene compounds of formula: ##STR1## wherein R.sub.1 represents an alkyl radical containing 1 to 4 carbon atoms, a cycloalkyl, cycloalkenyl or aralkyl radical, R.sub.2 represents an atom of hydrogen or a methyl radical with the proviso that when R.sub.2 represents methyl R.sub.1 represents alkyl, or R.sub.1 and R.sub.2, when they are taken together, represent, with the carbon atom to which they are attached, a cyclopolymethylene radical having from 3 to 6 carbon atoms, whereby a reaction medium comprising a solvent and a compound of the general formula: ##STR2## wherein R.sub.3 represents an atom of alkali metal, and R.sub.4 represents an atom of hydrogen or of alkali metal is treated at a temperature between -20.degree. and +80.degree. C with the appropriate quantity of a halide of the general formula:R.sub.5 X IIIin which X represents an atom of fluorine, chlorine, bromine, or iodine and R.sub.Type: GrantFiled: March 1, 1976Date of Patent: August 22, 1978Assignee: LabazInventors: Charles Pigerol, Paul de Cointet DE Fillain, Claude Grain, Jacques Le Blay
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Patent number: 4098706Abstract: This application relates to new lubricating associations for thermoplastic materials, which comprise at least two lubricating agents selected from 1,2-propanediol dibehenate, thiodiglycol dibehenate, diethyleneglycol dibehenate, triethyleneglycol dibehenate, trimethylolpropane tribehenate, dipentaerythrite pentabehenate, 1,4-butanediol dibehenate, glyceryl tribehenate, pentaerythrite tetrabehenate and one metallic salt of behenic acid.This application relates also to the polymers and co-polymers of vinyl chloride containing said lubricating associations.Type: GrantFiled: May 5, 1976Date of Patent: July 4, 1978Assignee: Sapchim-Fournier-CimagInventors: Jean Boussely, Marie-Madeleine Chandavoine, Michel Chignac, Claude Grain, Charles Pigerol
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Patent number: 4096112Abstract: New stabilizers for polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: ##STR1## wherein R.sub.1 and R.sub.2, which are the same or different, each represent a branched- or straight-chain alkyl group containing from 1 to 12 carbon atoms, a cyclohexyl radical, a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms, a benzyloxy radical, a hydroxy radical or R.sub.1 and R.sub.2 represent together an alkylenedioxy radical containing from 1 to 3 carbon atoms, R.sub.3 represents a hydrogen atom, a methyl or methoxy radical, with the proviso that one at least of the substituents R.sub.1 or R.sub.2 does not represent an alkyl radical.Type: GrantFiled: December 29, 1976Date of Patent: June 20, 1978Assignee: LabazInventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de Cointet DE Fillain, Souli Nanthavong
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Patent number: 4057530Abstract: New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: ##STR1## wherein R represents a phenyl radical, an amino group, optionally substituted by an acetyl or benzoyl radical, a mercapto group, optionally substituted by a branched-or straight-chain alkyl group containing from 1 to 12 carbon atoms or by a cyclohexyl radical, a carboxyl radical, a radical represented by the formula:R.sub.1 O--wherein R.sub.1 represents a hydrogen atom, an isopropyl, carboxymethyl, carbethoxymethyl, carbethoxyisopropyl, acetyl, docosanoyl, benzoyl, benzyl, or allyl radical or a branched-or straight-chain alkyl radical containing from 6 to 12 carbon atoms.Type: GrantFiled: June 2, 1975Date of Patent: November 8, 1977Assignee: LabazInventors: Charles Pigerol, Paul DE Cointet de Fillain, Souli Nanthavong, Jacques Le Blay
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Patent number: 4057644Abstract: Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each represent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.Type: GrantFiled: July 22, 1976Date of Patent: November 8, 1977Assignee: LabazInventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec, Madeleine Broll
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Patent number: 4048334Abstract: Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.tbd.CH--R.sub.4 or an alkynyl radical of the formula C=C--R.sub.4, in which R.sub.4 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.1, R.sub.2 and R.sub.3 being such that no compound of formula I possesses more than 13 carbon atoms.They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.Type: GrantFiled: August 22, 1975Date of Patent: September 13, 1977Assignee: LabazInventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec
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Patent number: 4026925Abstract: Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH=CH--R.sub.4 or an alkynyl radical of the formula C.tbd.C--R.sub.4, in which R.sub.4 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.1, R.sub.2 and R.sub.3 being such that no compound of formula I possesses more than 13 carbon atoms.They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.Type: GrantFiled: May 15, 1975Date of Patent: May 31, 1977Assignee: LabazInventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec
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Patent number: 4024155Abstract: New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: ##STR1## wherein R.sub.1 and R.sub.2, which are the same or different, each represent a branched- or straight-chain alkyl group containing from 1 to 12 carbon atoms, a cyclohexyl radical, a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms, a benzyloxy radical, a hydroxy radical or R.sub.1 and R.sub.2 represent together an alkylenedioxy radical containing from 1 to 3 carbon atoms, R.sub.3 represents a hydrogen atom, a methyl or methoxy radical, with the proviso that one at least of the substituents R.sub.1 or R.sub.2 does not represent an alkyl radical.Type: GrantFiled: May 30, 1975Date of Patent: May 17, 1977Assignee: LabazInventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de Cointet DE Fillain, Souli Nanthavong
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Patent number: 3988472Abstract: Tri-n-propylacetamide and tri-n-propylacetic acid salts are useful in the treatment of pathological variations of mood and as anticonvulsants and tranquillizers.Type: GrantFiled: November 10, 1975Date of Patent: October 26, 1976Assignee: LabazInventors: Charles Pigerol, Pierre Luc Eymard
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Patent number: 3958011Abstract: Tri-n-propylacetic acid and its alkali metal salts are useful in the treatment of central neurological troubles due to or accompanied by cerebral ischemia and as tranquillizers.Type: GrantFiled: March 31, 1975Date of Patent: May 18, 1976Assignee: LabazInventors: Charles Pigerol, Pierre Luc Eymard