Patents by Inventor Charles Q. Meng

Charles Q. Meng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel salt forms of poorly soluble probucol esters and ethers
    Publication number: 20040082807
    Abstract: Organic amine salts of compounds of the formula: 1
    Type: Application
    Filed: July 14, 2003
    Publication date: April 29, 2004
    Inventor: Charles Q. Meng
  • Chalcone derivatives and their use to treat diseases
    Publication number: 20040048858
    Abstract: The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula 1
    Type: Application
    Filed: December 19, 2002
    Publication date: March 11, 2004
    Inventors: James A. Sikorski, Charles Q. Meng, M. David Weingarten, Kimberly J. Worsencroft, Liming Ni
  • 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
    Publication number: 20030236298
    Abstract: It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.
    Type: Application
    Filed: May 21, 2003
    Publication date: December 25, 2003
    Applicant: Atherogenics Pharmaceuticals, Inc.
    Inventors: Charles Q. Meng, Liming Ni, James A. Sikorski, Lee K. Hoong
  • 1,3-Bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
    Publication number: 20030232877
    Abstract: The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula 1
    Type: Application
    Filed: December 19, 2002
    Publication date: December 18, 2003
    Inventors: James A. Sikorski, Charles Q. Meng, M. David Weingarten
  • 1, 3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
    Patent number: 6608101
    Abstract: It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: August 19, 2003
    Assignee: Atherogenics, Inc.
    Inventors: Liming Ni, Lee K. Hoong, James A. Sikorski, Charles Q. Meng
  • Compounds and methods for the inhibition of the expression of VCAM-1
    Patent number: 6602914
    Abstract: This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: August 5, 2003
    Assignee: AtheroGenics, Inc.
    Inventor: Charles Q. Meng
  • Compounds and methods for the inhibition of the expression of VCAM-1
    Publication number: 20020193446
    Abstract: This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Inventor: Charles Q. Meng
  • Compounds and methods for the inhibition of the expression of VCAM-1
    Publication number: 20020188118
    Abstract: This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 12, 2002
    Inventor: Charles Q. Meng
  • Compounds and methods for the inhibition of the expression of VCAM-1
    Publication number: 20020169215
    Abstract: This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
    Type: Application
    Filed: April 2, 2002
    Publication date: November 14, 2002
    Inventor: Charles Q. Meng
  • Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
    Publication number: 20020016364
    Abstract: It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
    Type: Application
    Filed: April 11, 2001
    Publication date: February 7, 2002
    Inventors: Jayraz Luchoomun, Charles Q. Meng, Uday Saxena
  • Thioketals and thioethers for inhibiting the expression of VCAM-1
    Publication number: 20020016300
    Abstract: Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune diseases, neurological disorders, and cancer. The compounds also can be used to treat hyperlipidemia and/or hypercholesterolemia.
    Type: Application
    Filed: March 21, 2001
    Publication date: February 7, 2002
    Inventors: Charles Q. Meng, Lee K. Hoong, Patricia K. Somers