Patents by Inventor Charles R. Degenhardt
Charles R. Degenhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5292501Abstract: The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR1## or the salts thereof, wherein R is a C.sub.1 -C.sub.8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition.This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface.Type: GrantFiled: April 26, 1993Date of Patent: March 8, 1994Inventors: Charles R. Degenhardt, Barbara A. Kozikowski
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Patent number: 5213789Abstract: The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-containing copolymer having the formula ##STR1## or the salts thereof, wherein n is in the range of from about 200 to about 14,000, m is in the range of from about 2 to about 5,000, and p is in the range of from 1 to 3; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the teeth which are contacted with the composition.This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-containing copolymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-containing copolymer to the oral cavity. The application does not stain the teeth on which it is made.Type: GrantFiled: December 26, 1991Date of Patent: May 25, 1993Assignee: The Procter & Gamble CompanyInventors: Charles R. Degenhardt, Barbara A. Kozikowski
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Patent number: 5093170Abstract: The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR1## or the salts thereof, wherein R is a C.sub.1 -C.sub.8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition.This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface.Type: GrantFiled: June 25, 1990Date of Patent: March 3, 1992Assignee: The Procter & Gamble Co.Inventors: Charles R. Degenhardt, Barbara A. Kozikowski
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Patent number: 5011913Abstract: Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromoleules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.Type: GrantFiled: May 11, 1989Date of Patent: April 30, 1991Assignee: The Procter & Gamble CompanyInventors: James J. Benedict, Charles R. Degenhardt, James W. Poser
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Patent number: 5009882Abstract: The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a plaque-inhibiting carboxy starch polymer comprising the formula ##STR1## wherein W and X are independently selected from CH.sub.2 OH, CHO and CO.sub.2 H, or the neutralized carboxylic acid salts thereof, Y and Z are independently selected from CHO and CO.sub.2 H, or the neutralized carboxylic acid salts thereof, n is in the range of from about 5 to about 2500, m is in the range of from 0 to about 2500, provided that the sum of n and m ranges from about 5 to about 2500, and the degree of carboxylation of said active agent ranges from about 1 to about 3; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the teeth which are contacted with the composition.This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity.Type: GrantFiled: May 21, 1990Date of Patent: April 23, 1991Assignee: The Proctor & Gamble CompanyInventors: Charles R. Degenhardt, Barbara A. Kozikowski
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Patent number: 4939284Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.Type: GrantFiled: January 24, 1989Date of Patent: July 3, 1990Assignee: The Procter & Gamble CompanyInventor: Charles R. Degenhardt
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Patent number: 4877603Abstract: Anticalculus and antiplaque oral care compositions containing geminal diphosphonate polymer anticalculus agents and a pharmaceutically acceptable carrier, and method for inhibiting formation of calculus and plaque in the oral cavity by treatment with geminal diphosphonate polymers.Type: GrantFiled: November 28, 1988Date of Patent: October 31, 1989Assignee: The Procter & Gamble CompanyInventors: Charles R. Degenhardt, Barbara A. Kozikowski
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Patent number: 4830847Abstract: Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromolecules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.Type: GrantFiled: June 28, 1985Date of Patent: May 16, 1989Assignee: The Procter & Gamble CompanyInventors: James J. Benedict, Charles R. Degenhardt, James W. Poser
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Patent number: 4820698Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.Type: GrantFiled: April 23, 1986Date of Patent: April 11, 1989Assignee: The Procter & Gamble CompanyInventors: Charles R. Degenhardt, Duane L. Charbonneau
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Patent number: 4504462Abstract: A process for making a lyophilized composition, useful for skeletal imaging containing diphosphonates, stannous reductant, and an ascorbate or reductate stabilizer. The process comprises (1) preparing an aqueous solution of diphosphonate, reductant, and stabilizer, (2) adjusting the pH of the solution formed in step one to a pH in the range from about 5.5 to about 6.5, and (3) lyophilizing the pH adjusted solution.Type: GrantFiled: June 10, 1982Date of Patent: March 12, 1985Assignee: Mallinckrodt, Inc.Inventors: Barry F. Van Duzee, Charles R. Degenhardt
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Patent number: 4440738Abstract: Stable compositions, useful as technetium-99m-based imaging agents, comprise reductic acid or certain structurally-related compounds in combination with a pertechnetate reductant or dissolved in pertechnetate-99m solution. The compositions are especially useful, in combination with a phosphate or phosphonate bone-targeting carrier, for skeletal imaging.Type: GrantFiled: June 10, 1982Date of Patent: April 3, 1984Assignee: Mallinckrodt, Inc.Inventors: Mahdi B. Fawzi, James J. Benedict, Joseph E. Bugaj, Charles R. Degenhardt, Barry F. Van Duzee
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Patent number: 4259249Abstract: A method of preparing hydroxyl substituted ammonio carboxylates comprising a single step of reacting an epoxy ester with a tertiary amine in aqueous alcohol, yielding directly said hydroxyl substituted ammonio carboxylates. The hydroxyl substituted ammonio carboxylates are useful as detersive surfactants and as oral anti-ulcer agents.Type: GrantFiled: June 13, 1979Date of Patent: March 31, 1981Assignee: The Procter & Gamble CompanyInventor: Charles R. Degenhardt