Abstract: 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof having the formula ##STR1## and the non-toxic pharmacologically acceptable acid addition salts thereof; wherein R is hydrogen, benzyl, or an alkyl radical of 1 to 7 carbon atoms; R.sup.1 is hydrogen or an alkyl radical of 1 to 7 carbon atoms; R.sup.2 in each occurrence is hydrogen, an alkyl radical of 1 to 7 carbon atoms or alkoxy radical of 1 to 7 carbon atoms, alike or different; Ar is phenyl optionally substituted with one or more halogen, an alkyl radical of 1 to 7 carbon atoms, or alkoxy radical of 1 to 7 carbon atoms; and n is positive integer less than 4, are disclosed. These compounds are useful because of their anti-arrhythmic, antimicrobial and central nervous system activity.

Abstract: 2-Aryl-4-(1-piperazinyl)-3H-1,5-benzodiazepines of the formula ##STR1## wherein R is hydrogen, alkyl having from 1 to 7 carbon atoms or phenyl; Ar is phenyl, trifluoromethylphenyl or phenyl substituted with 1 or 2 halogen, alkyl having from 1 to 4 carbon atoms or alkoxy having from 1 to 4 carbon atoms; X and Y are each hydrogen, halogen, alkyl having from 1 to 4 carbon atoms or alkoxy having from 1 to 4 carbon atoms; and the dotted line represents a single bond wherein hydrogen is attached to N or a double bond. These compounds are useful as muscle relaxants.

Abstract: Preparation and the antiarrhythmic and antimicrobial properties of 5-alkyl-10-(aminocarbonyl/aminomethyl/cyano)-10,11-dihydro-5H-dibenz[b,f]a zepine-10-alkanamines and equivalent salts are disclosed.

Abstract: 2-Substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines having anti-arrhythmic activity are described herein. The subject compounds can be prepared by reduction of the corresponding 2-Substituted-9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridines. The compounds additionally display antibacterial activity.

Abstract: 1-(Substituted-aminoalkyl)-3-benzoyl-4-hydroxy-4-phenylpiperidines and related compounds having anti-arrhythmic activity are described herein. The 3-benzoyl compounds can be prepared by condensing the appropriate diamine with acetophenone and formaldehyde. The related 3-(.alpha.-hydroxybenzyl) compounds are prepared by reduction of the corresponding 3-benzoyl compounds.

Abstract: Preparation and the anticonvulsant utility of 1-(10-cyano/halo-5H-dibenzo[a,d]cyclohepten-5-yl)-4-[(pyridylmethylene)ami no]piperazines are disclosed.