Abstract: An artificial functional spinal unit including an expandable intervertebral implant that can be inserted via a posterior surgical approach and used with one or more facet replacement devices to provide an anatomically correct range of motion is described. Lordotic and non-lordotic expandable, articulating implants and cages are described, along with embodiments of facet replacement devices and instruments for insertion. Methods of insertion are also described.

Abstract: A method of inserting an intervertebral implant between vertebrae in a human spine includes positioning the intervertebral implant in a closed configuration between the vertebrae. After positioning the intervertebral implant, the intervertebral implant is activated to increase a height of the intervertebral implant. After activation, at least a portion of the increased height of the intervertebral implant is maintained.

Abstract: An expandable intervertebral implant for insertion between vertebrae of a human spine is described. The expandable intervertebral implant includes an upper body that engages a first vertebra of the human spine, a lower body that engages a second vertebra of the human spine, an insert, and a spacer. The insert may be positioned between an inferior surface of the upper body and a superior surface of the lower body. The insert may be engaged to increase a separation distance between the lower body and the upper body. A spacer may be inserted between the upper body and the lower body to maintain the increased separation distance between the upper body and the lower body after expansion of the intervertebral implant in the human spine.

Abstract: An improved design for subcutaneous monitors that addresses the problem caused by bubbles of air may remain in the pocket in which the device is implanted. As implantable monitors and their associated electrodes are reduced in size, these bubbles may in some cases cover one or both electrodes, interfering with sensing of the ECG signal. The invention addresses this problem by configuring the electrodes to increase the pressure of the electrodes against the tissue above the electrodes relative to the pressures exerted by the adjacent outer facing surfaces of the device.

Abstract: Various techniques are described for periodically performing a calibration routine to calibrate a low-power system clock within an implantable medical device (IMD) based on a high accuracy reference clock also included in the IMD. The system clock is powered continuously, and the reference clock is only powered on during the calibration routine. The techniques include determining a clock error of the system clock based on a difference between frequencies of the system clock and the reference clock over a fixed number of clock cycles, and adjusting a trim value of the system clock to compensate for the clock error. Calibrating the system clock with a delta-sigma loop, for example, reduces the clock error over time. This allows accurate adjustment of the system clock to compensate for errors due to trim resolution, circuit noise and temperature.

Abstract: The invention disclosed herein provides methods and materials for observing the state of a sensor, for example those used by diabetic patients to monitor blood glucose levels. Typically a voltage such as a voltage pulse is applied to the sensor in order to solicit a current response from which for example, factors such as impedance values can be derived. Such values can then be used as indicators of a sensor's state, for example the state of sensor hydration, sensor noise, sensor offset, sensor drift or the like.

Abstract: An articulating expandable intervertebral implant is described for insertion between vertebrae of a human spine. The articulating expandable intervertebral implant includes an upper body that engages a first vertebra, a lower body that engages a second vertebra, and an insert. The inferior surface of the upper body may include a concave portion. The superior surface of the insert may include a convex portion. The insert may be positioned between the superior surface of the lower body and the concave portion of the inferior surface of the upper body. In some embodiments, an expansion member may engage the insert to increase a height of the intervertebral implant and/or allow or increase articulation of the upper body with respect to the insert. The insert may include one or more features designed to limit articulation of the upper body with respect to the insert.

Abstract: An expandable intervertebral implant is described for insertion between vertebrae of a human spine. The intervertebral implant includes an upper body that engages a first vertebra of the human spine, a lower body that engages a second vertebra of the human spine, an insert, and an expansion member. The expansion member may include a first angled portion and a second angled portion. The expansion member may be advanced such that a first angled portion of the expansion member engages an angled portion of the insert to increase a separation distance between the upper body and the lower body of the intervertebral implant. An advancing element may engage a second angled portion of the expansion member such that a direction of advancement of the advancing element is different than the direction of advancement of the expansion member.

Abstract: An expandable articulating intervertebral implant is described for insertion between vertebrae of a human spine. The expandable intervertebral implant includes an upper body that engages a first vertebra of the human spine, a lower body that engages a second vertebra of the human spine, and an insert. The upper body may include an upper portion and a lower portion. The insert may be positioned between an inferior surface of the lower portion of the upper body and a superior surface of the lower body. The insert may be translated or rotated to increase a separation distance between the lower body and the upper body. A spacer may be inserted between the upper body and the lower body to maintain at least a portion of the increased separation distance between the upper body and the lower body after expansion of the intervertebral implant in the human spine.

Abstract: An articulating expandable intervertebral implant is described. The articulating expandable intervertebral implant includes an upper body that engages a first vertebra of the human spine, a lower body that engages a second vertebra of the human spine, an insert, and an advancing element. In some embodiments, the upper body includes an upper portion and a lower portion that are configured to articulate with respect to each other. The advancing element may be configured to engage the insert such that advancement of the advancing element causes the insert to at least partially rotate between the upper body and the lower body. Rotation of the insert may cause the insert to interact with at least a portion of the upper body or the lower body to increase a height of the intervertebral implant and/or to allow articulation of the intervertebral implant after insertion of the intervertebral implant between the vertebrae.

Abstract: A dynamic interbody device for a human spine is provided to stabilize a human spine. In some embodiments, the dynamic interbody device includes a first member and a second member. In some embodiments, dynamic interbody device includes a first member, a second member and a third member. In some embodiments, the dynamic interbody device may include a bridge. The bridge may be used to couple the dynamic interbody device to a posterior stabilization system. In some embodiments, two dynamic interbody devices may be placed in a disc space between vertebrae.

Abstract: A dynamic posterior stabilization system is provided to stabilize a human spine. In some embodiments, the dynamic posterior stabilization system includes a first bone fastener, a second bone fastener, and an elongated member coupled to the first bone fastener and the second bone fastener. The longitudinal position of the elongated member relative to the first bone fastener may be fixed. The longitudinal position of the second bone fastener relative to the elongated member may vary so that the dynamic posterior stabilization system can accommodate flexion/extension and/or lateral bending. The dynamic posterior stabilization system may also be able to accommodate axial rotation. Bias members may be coupled to the elongated member. The bias members may allow the dynamic posterior stabilization system to mimic the resistance behavior of a normal functional spinal unit.

Abstract: A method and apparatus for sensing improvement using pressure data. The method and apparatus may be used in an implantable medical device to confirm that an EGM event signifies a true mechanical cardiac activity and not just electrical oversensing. The mechanical activity may be used to create a mechanical marker channel in the implantable medical device.

Abstract: An artificial functional spinal unit is provided comprising, generally, an expandable artificial intervertebral implant that can be placed via a posterior surgical approach and used in conjunction with one or more artificial facet joints to provide an anatomically correct range of motion. Expandable artificial intervertebral implants in both lordotic and non-lordotic designs are disclosed, as well as lordotic and non-lordotic expandable cages for both PLIF (posterior lumber interbody fusion) and TLIF (transforaminal lumbar interbody fusion) procedures. The expandable implants may have various shapes, such as round, square, rectangular, banana-shaped, kidney-shaped, or other similar shapes.

Abstract: Method and apparatus for sensing improvement using pressure data. The method and apparatus may be used in an implantable medical device to confirm that an EGM event signifies a true mechanical cardiac activity and not just electrical oversensing. The mechanical activity may be used to create a mechanical marker channel in the implantable medical device.

Abstract: An artificial functional spinal unit including an expandable intervertebral implant that can be inserted via a posterior surgical approach and used with one or more facet replacement devices to provide an anatomically correct range of motion is described. Lordotic and non-lordotic expandable, articulating implants and cages are described, along with embodiments of facet replacement devices and instruments for insertion. Methods of insertion are also described.

Abstract: A stabilization system for a human spine is provided comprising at least two dynamic interbody device and at least one dynamic posterior stabilization system. In some embodiments the stabilization system comprises a pair of dynamic interbody devices and a pair of dynamic posterior stabilization systems. The dynamic interbody devices may work in conjunction with the dynamic posterior stabilization systems to allow for movement of vertebrae coupled to the stabilization system. The dynamic posterior stabilization systems may provide resistance to movement that mimics the resistance provided by a normal functional spinal unit. In some embodiments, a bridge may couple a dynamic interbody device to a dynamic posterior stabilization system.

Abstract: A stabilization system for a human spine is provided comprising at least one dynamic interbody device and at least one dynamic posterior stabilization system. In some embodiments the stabilization system comprises a pair of dynamic interbody devices and a pair of dynamic posterior stabilization systems. In some embodiments, a bridge may couple a dynamic interbody device to a dynamic posterior stabilization system. In some embodiments, an elongated member of the dynamic posterior stabilization system may be curved.

Abstract: A stabilization system for a human spine is provided comprising at least one dynamic interbody device and at least two dynamic posterior stabilization systems. The dynamic posterior stabilization system may be coupled on contralateral sides of vertebrae. In some embodiments, a bridge may couple a dynamic interbody device to a dynamic posterior stabilization system.

Abstract: An expandable intervertebral implant for insertion between vertebrae of a human spine is described. The intervertebral implant includes an upper body that engages a first vertebra of the human spine, a lower body that engages a second vertebra of the human spine, an insert, and an advancing element. The advancing element may engage the insert such that advancement of the advancing element causes the insert to at least partially rotate between the upper body and the lower body. Rotation of the insert may cause the insert to interact with at least a portion of the upper body or at least a portion of the lower body to increase a separation distance between the upper body and the lower body, thereby increasing a height of the intervertebral implant after insertion of the implant between the first vertebra and the second vertebra of the human spine.