Patents by Inventor Charles R. Hutchinson

Charles R. Hutchinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20160279248
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Application
    Filed: June 7, 2016
    Publication date: September 29, 2016
    Inventors: Charles R. Hutchinson, James R. Prudent, Jon S. Thorson
  • Extracellular targeted drug conjugates
    Patent number: 9364554
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: June 14, 2016
    Assignee: Centrose LLC
    Inventors: Charles R. Hutchinson, James R. Prudent, Jon S. Thorson
  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20130336994
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Application
    Filed: May 20, 2013
    Publication date: December 19, 2013
    Applicant: CENTROSE, LLC
    Inventors: Charles R. Hutchinson, James R. Prudent, Jon S. Thorson
  • GLYCOSIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20110319350
    Abstract: The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
    Type: Application
    Filed: August 7, 2009
    Publication date: December 29, 2011
    Applicant: CENTROSE, LLC
    Inventors: Charles R. Hutchinson, Mohammed S. Shekhani, James R. Prudent
  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20110064752
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 17, 2011
    Applicant: CENTROSE, LLC
    Inventors: Charles R. Hutchinson, Jill Hutchinson Bollettieri, James R. Prudent, Jon S. Thorson
  • Method of producing antihypercholesterolemic agents
    Patent number: 6943017
    Abstract: A method of increasing the production of lovastatin or monacolin J in a lovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with the A. terreus D4B segment, wherein the segment is translated and where an increase in lovastatin production occurs.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: September 13, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Charles R. Hutchinson, Jonathan Kennedy, Cheonseok Park
  • Method of producing antihypercholesterolemic agents
    Publication number: 20040033570
    Abstract: A method of increasing the production of lovastatin or monacolin J in a iovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with the A. terreus D4B segment, wherein the segment is translated and where an increase in lovastatin production occurs.
    Type: Application
    Filed: March 28, 2002
    Publication date: February 19, 2004
    Inventors: Charles R. Hutchinson, Jonathan Kennedy, Cheonseok Park
  • Method of producing antihypercholesterolemic agents
    Patent number: 6391583
    Abstract: A method of increasing the production of lovastatin or monacolin J in a lovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with the A. terreus D4B segment, wherein the segment is translated and where an increase in lovastatin production occurs.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: May 21, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Charles R. Hutchinson, Jonathan Kennedy, Cheonseok Park
  • Process for preparing doxorubicin
    Patent number: 5955319
    Abstract: The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Pharmacia & Upjohn, S.p.A.
    Inventors: Silvia Filippini, Umberto Breme, Anna Luisa Colombo, Natasha Lomovskaya, Leonid Fonstein, Sharee Otten, Charles R. Hutchinson
  • Process for preparing daunorubicin
    Patent number: 5563064
    Abstract: The ability to convert carminomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 2, 3 and 4 and a nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O-methyltransferase.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: October 8, 1996
    Assignee: Farmitalia Carlo Erba S.R.L.
    Inventors: Charles R. Hutchinson, Krishna M. Madduri, Francesca Torti, Anna L. Colombo
  • Process for preparing daunorubicin
    Patent number: 5364781
    Abstract: The ability to convert carminomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 2, 3 & 4 and nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O-methyltransferase.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: November 15, 1994
    Assignee: Farmitalia Carlo ERBA S.r.l
    Inventors: Charles R. Hutchinson, Krishna M. Madduri, Francesca Torti, Anna L. Colombo