Abstract: Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.

Abstract: Disclosed are methods, including automated methods, for identifying a compound that impacts a characteristic of a lipid raft phase domain, a characteristic of a non-raft phase domain, and/or a characteristic of one or more membrane proteins.

Abstract: Ticket cleaner apparatus is described which is adapted to remove a coating from the surface of a game ticket to reveal or expose characters on the ticket. The apparatus includes: (a) a housing which includes an opening to receive the ticket; (b) a rotatable cleaning element supported within the housing; (c) positioning means adapted to position the ticket within the housing so that the coating on the ticket is in contact with the cleaning element; and (d) power means which is adapted to rotate the cleaning element while in contact with the coating on the ticket.