Abstract: Systems and methods are provided to supply medical data to a third party in accordance with a number of configurable distribution parameters. A configurable notification record is provided to define at least one distribution parameter that defines the manner in which medical data is distributed. The distribution parameter may be the third party to be provided medical data, the type of medical data to be provided, the medium over which an alert is to be transmitted and the conditions under which the alert is to be provided. In operation, a wireless communications device receives the medical data from a monitor borne by an ambulatory patient and wirelessly transmits at least some of the medical data to a computer network. Based upon the configurable notification record stored by the computer network, the computer network can transmit the medical data and/or an alert to the third party pursuant to the distribution parameters.

Abstract: The present invention is directed to the method and apparatus for the cytoplasmic loading of macromolecules into living cells by an impact-mediated procedure that impacts the cells with a predetermined number of solid particles in a blast of propellant gas. More specifically, the present invention is directed to an impact-mediated procedure that is altered by gravitational conditions and is preferably carried out under hypergravity conditions. Further, the present invention is directed to an IML method and apparatus for consistently and reproducibly loading macromolecules into the cytoplasm of living cells via membrane wounding at significantly higher efficiencies than can be accomplished using existing methodologies. The IML procedure directs a blast of propellant gas through a rupturable membrane on which solid particles are supported in order to achieve insertion of a predetermined number of particles into the propellant blast.