Abstract: The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or functions may be desirable. Formula (I): Z1—X—Z2 wherein a) Z1 represents CO2H or a derivative thereof; b) Z2 represents F, H, —CO2H or a derivative thereof; and c) X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

Abstract: The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipis of eicosanoid status or functions may be desirable. Formula (I): Z1—Z1—Z2 wherein a) Z1 represents CO2H or a derivative thereof; b) Z2 represents F, H, —CO2H or a derivative thereof; and c) X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

Abstract: A device for applying night-visible road markings includes a material hopper, a floor gate, a pair of side runners and a plurality of vertically oriented shutters. When the floor gate is moved away from an outlet extending through a bottom side of the hopper, marking material flows from the hopper, through the outlet and onto the surface of a road. The vertically oriented shutters are positioned between the side runners, which serve as side forms for marking material dispensed onto the road surface, and rearwardly of the hopper outlet. The distance between the bottom edges of the shutters and the road surface determines the amount of marking material that passes thereunder, thereby determining the thickness of the road marking. By positioning the shutters at different relative elevations, road markings of various patterns including markings having varying thicknesses across their width can be produced for increased reflectivity of the road markings.