Patents by Inventor Charles Romfo

Charles Romfo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and agents for screening for compounds capable of modulating gene expression
    Patent number: 9476870
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: October 25, 2016
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Liangxian Cao, Nikolai Naryshkin, Charles Romfo, Matthew C. Pellegrini, Anuradha Roy, Panayiota Trifillis, Christopher R. Trotta
  • Methods of screening for compounds for treating muscular dystrophy using human ALPHA7 integrin mRNA translation regulation
    Patent number: 9376725
    Abstract: The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular mystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: June 28, 2016
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Westley J. Friesen, Nikolai Naryshkin, Meenal Patel, Charles Romfo, Yuki Tomizawa, Ellen Welch, Jin Zhuo
  • Methods And Agents For Screening For Compounds Capable Of Modulating Gene Expression
    Publication number: 20150253304
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Application
    Filed: May 22, 2015
    Publication date: September 10, 2015
    Applicant: PTC Therapeutics, Inc.
    Inventors: Liangxian Cao, Nikolai Naryshkin, Charles Romfo, Matthew C. Pelligrini, Anuradha Mehta, Panayiota Trifillis, Christopher R. Trotta
  • Methods of screening for compounds for treating muscular dystrophy using mIGF1 mRNA translation regulation
    Patent number: 8741572
    Abstract: The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular mystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: June 3, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Westley J. Friesen, Nikolai Naryshkin, Meenal Patel, Charles Romfo, Yuki Tomizawa, Ellen Welch, Jin Zhou
  • METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20140135305
    Abstract: The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.
    Type: Application
    Filed: December 12, 2013
    Publication date: May 15, 2014
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Sergey V. Paushkin, Charles Romfo, Ellen Welch, Nikolai Naryshkin
  • Methods for treating spinal muscular atrophy
    Patent number: 8633019
    Abstract: The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: January 21, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Sergey V. Paushkin, Nikolai Naryshkin, Charles Romfo, Ellen Welch
  • Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation
    Patent number: 8283115
    Abstract: The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular dystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: October 9, 2012
    Assignee: PTC Therapeutics, Inc.
    Inventors: Westley J Friesen, Nikolai Naryshkin, Meenal Patel, Charles Romfo, Ellen Welch, Yuki Tomizawa, Jin Zhuo
  • METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20110086833
    Abstract: The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.
    Type: Application
    Filed: May 27, 2009
    Publication date: April 14, 2011
    Inventors: Sergey V. Paushkin, Nikolai Naryshkin, Charles Romfo, Ellen Welch
  • Inhibition of VEGF Translation
    Publication number: 20090209521
    Abstract: In accordance with the present invention, methods for inhibiting the translation of VEGF and methods for decreasing VEGF level by inhibiting VEGF translation are provided. In another aspect of the invention, compounds that inhibit the 5?-UTR-dependent translation of VEGF and methods for identifying such compounds are provided.
    Type: Application
    Filed: June 20, 2007
    Publication date: August 20, 2009
    Inventors: Liangxian Cao, Thomas Davis, Charles Romfo, Christopher Trotta
  • Inhibition of VEGF Translation
    Publication number: 20080064683
    Abstract: In accordance with the present invention, methods for inhibiting the translation of VEGF and methods for decreasing VEGF level by inhibiting VEGF translation are provided. In another aspect of the invention, compounds that inhibit the 5?-UTR-dependent translation of VEGF and methods for identifying such compounds are provided.
    Type: Application
    Filed: June 20, 2007
    Publication date: March 13, 2008
    Inventors: Liangxian Cao, Thomas Davis, Charles Romfo, Christopher Trotta
  • Methods and agents for screening for compounds capable of modulating gene expression
    Publication number: 20050048549
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Application
    Filed: July 21, 2004
    Publication date: March 3, 2005
    Inventors: Liangxian Cao, Anuradha Mehta, Nikolai Naryshkin, Matthew Pellegrini, Charles Romfo, Panayiota Trifillis, Christopher Trotta