Abstract: Disclosed herein am compositions and methods for targeting a novel regulatory element of agene. The compositions may be used in methods of modifying growth of a cell, decreasing cell fitness, increasing cell fitness, and/or treating cancer such as leukemia.

Abstract: A quick disconnect coupler with air safety check valve for placement in a compressed air system to receive an associated male plug on the end of a flexible hose connected to an associated air tool, said quick disconnect coupler providing means to hold the plug in a wedging configuration such that attempted withdrawal tightens the coupler's hold on the plug, and an air safety check valve that automatically cuts off the flow of compressed air through the valve when a certain air flow is exceeded, such as in the event that the air line connected to the plug is severed. Additionally, during removal of the plug from the inventive coupler, holding pins in the coupler retain the plug in order that compressed air in the flexible hose may be bled off before the plug is removed and additionally the coupler provides full flow air valves which air passageway exceed the size of the air passageway of a receiving male plug.