Abstract: Two-dimensional and/or three-dimensional polymeric or extended solid arrays comprising a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or ability of a compound to diffuse into cell membranes and/or transcellular permeability properties of a compound and/or the ionization state of a compound and/or the volume of distribution of a compound and/or the distribution of a compound into different tissues and/or the partitioning of a compound into cell organelles by monitoring the change in the fluorescence or phosphorescence upon exposure to the compound and optionally comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

Abstract: Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to screen a plurality of samples containing different species by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the sample and comparing it to a known change in fluorescence or phosphorescence, respectively.