Abstract: A pharmaceutical composition under the form of a sterile and injectable dosage form having a controlled release dosage form including colchicine for treating a joint disease such as osteoarthritis, Erosive Hand Osteoarthritis and any other type of chondropathy and/or treating a pain-associated joint disease and/or protecting joint, bone and/or cartilage, by intra-articular injection of the pharmaceutical composition into a joint. The time required to release 80% by weight of the colchicine is greater than one month and the colchicine is present in a concentration ranging from 1 to 27.5 mg per ml of the sterile and injectable dosage form. The composition of the controlled release dosage form including colchicine has an adapted in vitro dissolution profile. The composition has a formulation in the form of a powder and microparticles having a polymeric matrix and forms an associated kit or article of manufacture.

Abstract: The present invention relates to pharmaceutical composition under the form of a suspension comprising controlled release microparticles comprising colchicine for use in the treatment of crystal-associated and non-crystal associated acute inflammatory arthritis by intra-articular injection into a joint of said pharmaceutical composition, wherein the microparticles have a mean particle size greater than 10 pm, wherein the time required to release 80% by weight of the colchicine in the microparticles is greater than 1 day and may reach 15 days, wherein the colchicine is present in a concentration ranging from 2.5 to 2500 pg per ml of suspension and wherein the pharmaceutical composition has a volume ranging from 0.1 ml to 5 ml.

Abstract: The present disclosure provides compositions having drug-containing particles suspended in a continuous phase that is not saturated by the drug that are stable after being stored as a suspension for more than 1 month at 30° C.

Abstract: Heat fluxmeter incorporating a row of thermistors, whose electrical resistance varies significantly with the temperature and which are arranged on the outer surface of the container for accurately measuring the temperature thereof. The range of temperatures in the vicinity of the container is determined by means of a second row of thermistors. It is possible to deduce therefrom the heat flux leaving the container, i.e. the power emitted by the calorigenic material contained therein. The considerable sensitivity of this meter makes it possible to use it without excessively disturbing the thermal equilibrium so that the measurement can be carried out in a very short time.

Abstract: A heat seal monitoring device for a container, such as one containing a calogenic material, includes one or more seals, placed on a container surface element and having a plurality of electrically interconnected resistive components enclosed in a structure having a first material acting as a physical protection and a second material acting as a thermal insulation. Each initial cap seal is able to supply an electric signal representing the heat flux exchanged between the surface element and the seal.