Patents by Inventor Charles Semba

Charles Semba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF ANGIOGENIC FACTORS
    Publication number: 20230399377
    Abstract: A recombinant human Fc fusion protein comprises an Ig-like domain of a first human VEGF receptor, another different Ig-like domain of a second human VEGF receptor, at least yet another Ig-like domain of a third human VEGF receptor, and the Fc portion of the human IgG1. The fusion protein is useful in treating or controlling an ocular disease, condition, or disorder that has etiology in aberrant angiogenesis.
    Type: Application
    Filed: October 26, 2021
    Publication date: December 14, 2023
    Inventors: Jinzhong ZHANG, Wei Yong SHEN, Charles SEMBA, John Zhenze HU, Zhen Qin XIA
  • COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY
    Publication number: 20210338839
    Abstract: The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic retinopathy. One aspect of the invention provides for diagnosis of diabetic retinopathy and administration of a LFA-1 antagonist, after the patient is diagnosed with diabetic retinopathy.
    Type: Application
    Filed: February 22, 2021
    Publication date: November 4, 2021
    Inventors: John BURNIER, Thomas GADEK, Charles SEMBA
  • Compositions and methods for treatment of diabetic retinopathy
    Patent number: 10960087
    Abstract: The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic retinopathy. One aspect of the invention provides for diagnosis of diabetic retinopathy and administration of a LFA-1 antagonist, after the patient is diagnosed with diabetic retinopathy.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: March 30, 2021
    Assignee: NOVARTIS AG
    Inventors: John Burnier, Thomas Gadek, Charles Semba
  • COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY
    Publication number: 20160220702
    Abstract: The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic retinopathy. One aspect of the invention provides for diagnosis of diabetic retinopathy and administration of a LFA-1 antagonist, after the patient is diagnosed with diabetic retinopathy.
    Type: Application
    Filed: March 17, 2015
    Publication date: August 4, 2016
    Applicant: Sarcode Bioscience Inc.
    Inventors: John BURNIER, Thomas Gadek, Charles Semba
  • Compositions and methods for treatment of diabetic retinopathy
    Publication number: 20090155176
    Abstract: The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic retinopathy. One aspect of the invention provides for diagnosis of diabetic retinopathy and administration of a LFA-1 antagonist, after the patient is diagnosed with diabetic retinopathy.
    Type: Application
    Filed: October 17, 2008
    Publication date: June 18, 2009
    Applicant: SARcode Corporation
    Inventors: John Burnier, Thomas Gadek, Charles Semba
  • Wound Healing
    Publication number: 20070021342
    Abstract: Methods for accelerating and/or improving wound healing in a subject by administering vascular endothelial growth factor (VEGF) are provided.
    Type: Application
    Filed: September 25, 2006
    Publication date: January 25, 2007
    Applicant: Genentech, Inc.
    Inventors: Timothy Breen, Stuart Bunting, Charles Semba
  • PLASMINOGEN ACTIVATOR VARIANT FORMULATIONS
    Publication number: 20070014779
    Abstract: A solution is provided comprising about 0.01-0.05 mg/mL of tenecteplase in sterile water for injection or bacteriostatic water for injection and normal saline. Such solution is useful for delivery from a catheter and for treating a thrombotic disorder by exposing fibrin-rich fluid from the disorder to an effective amount thereof, as well as in kits. In a preferred embodiment, peripheral thrombosis is treated in a mammal comprising delivering to the mammal via a catheter an effective amount of this solution.
    Type: Application
    Filed: September 19, 2006
    Publication date: January 18, 2007
    Applicant: Genentech, Inc.
    Inventor: Charles Semba
  • Wound healing
    Publication number: 20060287234
    Abstract: Methods for accelerating and/or improving wound healing in a subject by administering vascular endothelial growth factor (VEGF) are provided.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 21, 2006
    Applicant: Genentech, Inc.
    Inventors: Timothy Breen, Stuart Bunting, Charles Semba
  • Catheter Composition and Uses Thereof
    Publication number: 20060257390
    Abstract: A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
    Type: Application
    Filed: June 23, 2006
    Publication date: November 16, 2006
    Applicant: Genentech, Inc.
    Inventor: Charles Semba
  • Catheter Composition and Uses Thereof
    Publication number: 20060246050
    Abstract: A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
    Type: Application
    Filed: June 23, 2006
    Publication date: November 2, 2006
    Applicant: Genentech, Inc.
    Inventor: Charles Semba