Abstract: Provided are single-domain antibodies (sdAbs), also called heavy-chain-only variable domains (VHHs) or camelids, that contain reactive, non-canonical amino acids (ncAAs) and crosslink to target antigen protein. The target antigen may be a toxin or a neurotoxin produced by a pathogenic organism or microorganism that causes or is associated with a disease or pathology. Compositions and methods using the reactive ncAA-containing sdAbs to treat subjects afflicted with a pathology caused by a toxin- or neurotoxin-producing pathogen, such as Botulinum, are provided. In some cases, the compositions and methods comprising the sdAbs treat or prevent intoxication and inhibit and/or neutralize toxin or neurotoxin activity.

Abstract: Multi-step methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express fusion proteins comprising an antigen binding protein which allows the red blood cell to bind a toxin or an antigen of a pathogen. Also described herein are methods for neutralizing a toxin or pathogen in a subject by administering enucleated red blood cells that express any of the fusion proteins provided herein.

Abstract: Upon authentication via a required multi-function hardware component, coupled to a computer system with one or more computer-readable media, having a software product embodied thereon, one implementation, described herein, conditionally blocks or grants access to the software functionality of that software product on that computer system.

Abstract: The present invention relates to an isolated monoclonal antibody mAb PAB-1, deposited at ATCC on 24 Jan. 2002 and accorded accession PTA-4005, which binds to a surface antigen on nematode L3. It also relates to the antigen which binds to the monoclonal antibody and uses for the monoclonal antibody and antigen in diagnosing and treating or preventing nematode infection.

Abstract: Systems and methods for providing a media device capabilities determination mechanism in a networked computing environment are provided. Some of today's operating systems and applications deliver a set of remoting features to enable a networked ecosystem of remote media consumption devices. These devices connect to the host and display a remoted media experience via remoting protocols and technologies. In this regard, the device capabilities determination mechanism of the invention enables a remote device to specify a custom set of media capabilities that should be remoted from the host to the remote device.