Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

Abstract: An orthopedic device is presented which comprise a horizontal base and a vertical support. The vertical support is connected toward the rear end of the horizontal base by a pivot mechanism and a tension mechanism. The pivot mechanism may include slots which allow the position of the vertical support to be adjusted. The tension mechanism may be a band such as an o-ring which is connected to both a first protrusion on the vertical support and a second protrusion on the rear end of the horizontal base. A locking mechanism may also be present to further connect the vertical support to the horizontal base.

Abstract: A method of forming a construction member by first froming a plurality of elements by superimposing and bonding together a plurality of sheets of plastic foam material, each in the range of from about 10 mm to about 25 mm thick, to form a laminate and attaching a wire mesh reenforcing member to a face of the laminate with parts of the mesh extending over the edge of the laminate. A plurality of the elements are placed adjacent one another and the extending portions of the mesh are connected. A continuous layer of mineral hydraulic material in then placed over the faces of the element to form the construction member.