Patents by Inventor Charles Stanford Harmon

Charles Stanford Harmon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases
    Patent number: 7723366
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: May 25, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Masahiro Nishimoto, David Mark Wallace, Sovouthy Tith, Steve Joel Brown, Charles Stanford Harmon, Gary D. Lopaschuk, Jason R. Dyck
  • Method for preparing imidazole derivatives
    Patent number: 7385063
    Abstract: The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: June 10, 2008
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Michael Nadzan, Sovouthy Tith, Masayuki Haramura, David Mark Wallace, Steve Joel Brown, Charles Stanford Harmon, Lin Zhang, Gary D. Lopaschuk, Jason R. Dyck
  • Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
    Publication number: 20040087627
    Abstract: The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds.
    Type: Application
    Filed: July 21, 2003
    Publication date: May 6, 2004
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Michael Nadzan, Sovouthy Tith, Masayuki Haramura, David Mark Wallace, Steve Joel Brown, Charles Stanford Harmon, Lin Zhang
  • Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors
    Publication number: 20040082564
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Application
    Filed: August 19, 2003
    Publication date: April 29, 2004
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Masahiro Nishimoto, David Mark Wallace, Sovouthy Tith, Steve Joel Brown, Charles Stanford Harmon
  • Imidazol derivatives
    Patent number: 5959113
    Abstract: This invention relates to novel imidazole derivatives of formula a ##STR1## and pharmaceutically acceptable salts of these compounds, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.7 and R.sup.8 are as disclosed herein. These compounds are protein kinase inhibitors useful in the treatment of atherosclerosis, psoriasis, alopecia, and tumors.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: September 28, 1999
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Charles Stanford Harmon, Markus Kamber, Anna Krasso, Wolfgang Pirson, Pierre-Charles Wyss