Abstract: A liquid biopsy system and method for the detection of SARS-CoV-2 antibodies in bodily fluids is described. In particular, the system is suitable for detecting SARS-CoV-2 antibodies in a saliva sample of a subject.

Abstract: An underwater device may include a waterproof housing defining a dry cavity and having a nonferrous switch interface wall. The underwater device may include a rotary switch within the dry cavity and including a switch body, and a switch shaft extending outwardly from the switch body. The underwater device may include a first magnetic body within the dry cavity and coupled between the switch shaft and the nonferrous switch interface wall, and a second magnetic body external from the waterproof housing and adjacent the nonferrous switch interface wall in alignment with the first magnetic body so that rotation of the second magnetic body rotates the switch shaft. Each of the first magnetic body and the second magnetic body may include a permanent magnet.

Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non-invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.

Abstract: A liquid biopsy system and method for the detection of biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject.

Abstract: An underwater device may include a waterproof housing defining a dry cavity and having a nonferrous switch interface wall. The underwater device may include a rotary switch within the dry cavity and including a switch body, and a switch shaft extending outwardly from the switch body. The underwater device may include a first magnetic body within the dry cavity and coupled between the switch shaft and the nonferrous switch interface wall, and a second magnetic body external from the waterproof housing and adjacent the nonferrous switch interface wall in alignment with the first magnetic body so that rotation of the second magnetic body rotates the switch shaft. Each of the first magnetic body and the second magnetic body may include a permanent magnet.

Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non-invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.

Abstract: The present disclosure provides methods for non-invasive prenatal screening (NIPS) of fetal aneuploidies. The present methods are based on analyzing cell-free fetal DNA (cff DNA) found in a pregnant woman's circulation through the next generation sequencing (NGS) technology. Particularly, the present methods analyze the relative abundance of different fetal genomic fragments present in the maternal sample, where the fragments can be aligned to particular chromosomal locations of the fetal genome. The relative abundance information is indicative as to whether a particular chromosome is overrepresented or underrepresented in a fetal genome as compared to normal individuals, and thus can be used to detect fetal aneuploidy. Additionally, methods for increasing the positive predictive values (PPV) of NIPS by excluding false-positive detections are also provided.

Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non-invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.