Patents by Inventor Charles Stuart Hoffman

Charles Stuart Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of phosphodiesterase 11 (PDE11)
    Patent number: 9173884
    Abstract: The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: November 3, 2015
    Assignee: Trustees of Boston College
    Inventors: Charles Stuart Hoffman, Ozge Ceyhan
  • INHIBITORS OF PHOSPODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATE CORTISOL PRODUCTION
    Publication number: 20140323503
    Abstract: The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency.
    Type: Application
    Filed: November 29, 2012
    Publication date: October 30, 2014
    Inventors: Charles Stuart Hoffman, Ozge Ceyhan