Abstract: Compounds of the formula: ##STR1## and their pharmaceutically acceptable non-toxic salts, wherein R.sub.1 is alkyl of 5 to 8 carbon atoms which is straight chained or .alpha.-substituted by a methyl group or .alpha.,.alpha.-disubstituted by methyl groups and R.sub.5 is hydrogen, R.sub.6 or CO.R.sub.6 wherein R.sub.6 is alkyl of 1 to 4 carbon atoms or alkyl of 1 to 4 carbon atoms substituted by NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are each hydrogen or alkyl of 1 to 4 carbon atoms or NR.sub.7 R.sub.8 is pyrrolidino, piperidino or morpholino, have been found to possess good antihypertensive activity while being of low-toxicity and substantially free of sedative side effects.

Abstract: Chromanols of the formula (II) ##SPC1##wherein R.sub.1 is a non-aromatic hydrocarbon group of 1-20 carbon atoms, R.sub.2 is a hydrocarbon group of 1-20 carbon atoms optionally substituted by a halogen atom and X is an optionally salted, etherified or acylated hydroxyl group, and N-oxides, acid-addition and quaternary salts thereof are shown to have anti-hypertensive activity. Their preparation and compositions containing them are described.

Abstract: Compounds of the formula: ##SPC1##And their pharmaceutically acceptable non-toxic salts, wherein R.sub.1 is alkyl of 5 to 8 carbon atoms which is straight chained or .alpha.-substituted by a methyl group or .alpha.,.alpha.-disubstituted by methyl groups and R.sub.5 is hydrogen, R.sub.6 or CO.R.sub.6 wherein R.sub.6 is alkyl of 1 to 4 carbon atoms or alkyl of 1 to 4 carbon atoms substituted by NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are each hydrogen or alkyl of 1 to 4 carbon atoms or NR.sub.7 R.sub.8 is pyrrolidino, piperidino or morpholino, have been found to possess good antihypertensive activity while being of low-toxicity and substantially free of sedative side effects.

Abstract: Compounds of the formula (I) ##SPC1##wherein R.sub.1 is an alkyl group of 4 - 8 carbon atoms, R.sub.2 is a naphthylmethyl group and their salts, ethers and esters have been found to possess good antihypertensive activity coupled with low toxicity. Such compounds may be prepared by the reduction of a quaternary salt of the correpsonding pyridyl compound.