Patents by Inventor Charles T. Harding

Charles T. Harding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NMR contrast agents
    Patent number: 5401491
    Abstract: An agent for modifying H.sub.2 O relaxation times in NMR diagnosis comprises a polysaccharide having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion. Polysaccharides include cellulose, starch, sepharose and dextran. Organic complexants include EDTA, DTPA and aminoethyl diphosphonate. A preferred metal ion is Gadolinium (III). The agents can be administered orally or parenterally.
    Type: Grant
    Filed: July 13, 1992
    Date of Patent: March 28, 1995
    Assignee: Guerbet S.A.
    Inventors: John P. Sadler, Charles T. Harding
  • Contrast agent for NMR imaging
    Patent number: 5250672
    Abstract: A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H.sub.2 O relaxation times in NMR diagnosis may comprise a polysaccharide to which is chemically linked both an NSL compound and an organic complexing agent to which is complexed a paramagnetic metal ion, such as Gd(III) or Cu(II). Polysaccharides include dextran, starch and cellulose. The preferred NSL compound is 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl.
    Type: Grant
    Filed: June 30, 1987
    Date of Patent: October 5, 1993
    Assignee: Guerbet S.A.
    Inventors: Peter J. Sadler, Charles T. Harding
  • Contrast agent for NMR scanning
    Patent number: 4880007
    Abstract: Complexes formed between (a) an amino di- or poly-phosphonate in which phosphonate groups comprise separate carbon atoms and (b) a paramagnetic metal ion such as Gd.sup.3+, have calcified tissue seeking properties which make them useful as contrast agents for investigating bone metabolism by NMR scanning. Two preferred poly-phosphonates are ethylenediamine tetramethylphosphonate and meta-xylene-diamine tetramethylphosphonate.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: November 14, 1989
    Assignee: Amersham International PLC
    Inventors: Peter J. Sadler, Charles T. Harding, James D. Kelly, Andrew B. McEwen