Abstract: Collapsible branched anastomosis devices allow for the formation of percutaneous vascular anastomoses using a Seldinger wire technique. This minimally invasive approach eliminates the need for a large surgical incision and also avoids the use of time consuming hand-suturing. The devices collapse to a fraction of their expanded volume and are configured to fit within a delivery sheath for over the wire delivery through a small incision in a blood vessel.

Abstract: A gallbladder cryoablation device can include an elongated body and a compliant thermal conductive wire. The elongated body includes a sharp distal end for insertion into a gallbladder, a liquid duct configured to insert a cryoablation fluid into the gallbladder, and an air duct configured to evacuate any gas displaced by the cryoablation fluid. The compliant thermal conductive wire is configured to expand from the elongated body and contact an inner wall of the gallbladder. A method of using the gallbladder cryoablation device includes inserting the elongated body, via the sharp distal end of the elongated body, into the gallbladder; positioning the compliant thermal conductive wire into the gallbladder until a sufficient portion of the compliant thermal conductive wire contacts the inner wall of the gallbladder; directing the cryoablation fluid into the cryoablation device; and cooling the compliant thermal conductive wire to a freezing temperature.

Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Abstract: Optical biopsy staining panels for in vivo or in situ fluorescent staining of optical tissue (or other appropriate tissue), e.g., for the purpose of a direct biopsy such as an optical biopsy. The stain panels may feature a combination of a nuclear stain and a cytoplasmic stain, as a means of functioning as an invivo or in situ hematoxylin and eosin (H&E) stain. Examples of said stains may include anthracyclines such as Daunomcibin, acriflavines like Proflavine, anthracenediones such as Mitoxantrone, phenothiazines like Methylene Blue, and tri- and tetra-heterocyclic dyes like Fluorescein, Phloxine B, Phenol Red, Rose Bengal, Congo Red, and Indigo Carmine.

Abstract: A bioimpedance system is used to obtain multi-bioimpedance measurements for guiding a clinical tool into a body. The system includes a medical instrument that is to be inserted into a body and a plurality of electrodes disposed on a surface of the medical instrument, embedded within the instrument, or both. Each electrode is configured to apply electrical current to the immediate surroundings in contact with the electrode in order to obtain multiple bioimpedance measurements. The bio-impedance measurements are used to guide the medical instrument during insertion and determine positioning and composition of the surrounding environment. The electrodes can also be used to direct application of electricity for cauterizing tissue.

Abstract: Collapsible branched anastomosis devices allow for the formation of percutaneous vascular anastomoses using a Seldinger wire technique. This minimally invasive approach eliminates the need for a large surgical incision and also avoids the use of time consuming hand-suturing. The devices collapse to a fraction of their expanded volume and are configured to fit within a delivery sheath for over the wire delivery through a small incision in a blood vessel.

Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.