Abstract: Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels. Each fluid channel includes a channel segment defined in a plane that is parallel to the device surface and parallel to each of the planes of the other channel segments. The plane of each channel segment is at a depth below the device surface that is different from the depth below the device surface for the other planes. Each channel segment may have a volume equal to the volume of each of the other channel segments. One of the fluid channels may include a plurality of channel segments serially connected to each other and each defined in a plane that is different from the planes of the other channel segments.

Abstract: A method of manufacturing a fitting for fluidic coupling in a chromatography system includes welding a tube sleeve and an inner tube at an endface of each of the tube sleeve and the inner tube to create a tube assembly having a welded tube assembly endface and polishing the welded tube assembly endface.

Abstract: A fitting for fluidic coupling in a chromatography system includes a compression screw including an axial bore, a threaded portion, and a drive end, a tube assembly including a tube sleeve and an inner tube disposed through the sleeve, the tube sleeve and the inner tube each extending to an endface of the tube assembly, the tube sleeve including an outer surface, a seal body extending between a first endface and a second endface, the first endface abutting the endface of the tube assembly, the seal body including an outer surface, and a collar secured to the outer surface of the tube sleeve and the outer surface of the seal body. Other Fittings, Methods of manufacture of fittings, and methods of fluidic coupling are further disclosed.

Abstract: A rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

Abstract: Described is a rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

Abstract: Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels. Each fluid channel includes a channel segment defined in a plane that is parallel to the device surface and parallel to each of the planes of the other channel segments. The plane of each channel segment is at a depth below the device surface that is different from the depth below the device surface for the other planes. Each channel segment may have a volume equal to the volume of each of the other channel segments. One of the fluid channels may include a plurality of channel segments serially connected to each other and each defined in a plane that is different from the planes of the other channel segments.

Abstract: A fitting for fluidic coupling in a chromatography system includes a compression screw including an axial bore, a threaded portion, and a drive end, a tube assembly including a tube sleeve and an inner tube disposed through the sleeve, the tube sleeve and the inner tube each extending to an endface of the tube assembly, the tube sleeve including an outer surface, a seal body extending between a first endface and a second endface, the first endface abutting the endface of the tube assembly, the seal body including an outer surface, and a collar secured to the outer surface of the tube sleeve and the outer surface of the seal body. Other Fittings, Methods of manufacture of fittings, and methods of fluidic coupling are further disclosed.

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

Abstract: Disclosed herein are fluidic couplings for high pressure sealing without tools that can apply large amounts of torque. One embodiment of a fitting includes a compression screw, a fluid-carrying tube extending through a bore in the compression screw, a sleeve disposed around the tube, and a seal coupled to the sleeve such that the seal surrounds a distal end portion of the sleeve. This positioning of the seal can facilitate more efficient sealing using less force and creating less dead volume. Such a fitting can be combined, for example, with a driver having a recess formed therein that can surround the compression screw and transfer rotational force thereto. The driver can include outer surface features, such as knurling, that can facilitate a user directly grasping and tightening the fitting. Further, the fitting can include at least one marking used to achieve a desired seal without overtightening.

Abstract: The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a calibration element configured to adjust a force applied to the poppet by the spring. The calibration element can include a through hole that forms part of the fluid pathway. The poppet can include a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat.

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

Abstract: A fluidic coupler assembly (10) for use in a light-guided flow cell comprises a coupler body (12) having a sealing face (10a), a tubular insert such as an optical fiber (16) passing through a through bore (14) of the coupler body and through a ferrule (18) located adjacent the sealing face of the coupler body. A backing plug (20) holds the ferrule in position within the coupler body.

Abstract: Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

Abstract: The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a calibration element configured to adjust a force applied to the poppet by the spring. The calibration element can include a through hole that forms part of the fluid pathway. The poppet can include a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat.

Abstract: A fluidic coupler assembly (10) for use in a light-guided flow cell comprises a coupler body (12) having a sealing face (10a), a tubular insert such as an optical fibre (16) passing through a through bore (14) of the coupler body and through a ferrule (18) located adjacent the sealing face of the coupler body. A backing plug (20) holds the ferrule in position within the coupler body.

Abstract: Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.

Abstract: Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidably receives a discharge tube. A union coupling the discharge tube to a source of fluid is slidably mounted to a mounting assembly holding the tube housing.

Abstract: A method of and program product for generating a report for use in assessing the credit worthiness of a borrower in a potential financing transaction with a lender, where the method comprises obtaining personal credit information about the borrower from a plurality of credit reporting services and combining the credit information, matching the borrower's address with a property in a database containing property information and obtaining property information pertaining to the matched property from the database. The method also includes obtaining value information about the matched property, aggregating the combined credit information about the borrower, the property information pertaining to the matched property and the value information pertaining to the matched property. A report is generated from the aggregated data.