Patents by Inventor Charles T. Roberts
Charles T. Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220187293Abstract: Embodiments provide for devices and methods of use for detecting one or more biomarkers of rheumatic disease in a subject. In an example, a method includes detecting citrullinated human serum albumin (HSA) in a biological sample via obtaining the biological sample from a subject, applying the biological sample to a lateral flow device under conditions sufficient for formation of an immunocomplex comprising anti-HSA antibody coupled to citrullinated HSA that is in turn coupled to anti-citrullinated HSA autoantibody, determining a quantity of the immunocomplex, and managing rheumatic disease associated with the subject. In this way, rheumatic disease may be effectively managed based at least in part on amounts of citrullinated HSA detected via rapid point-of-care test methodology.Type: ApplicationFiled: December 10, 2021Publication date: June 16, 2022Applicant: DIABETOMICS, INC.Inventors: Srinivasa R. NAGALLA, Charles T. ROBERTS
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Patent number: 8530175Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: GrantFiled: April 26, 2012Date of Patent: September 10, 2013Assignee: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Patent number: 8497077Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: GrantFiled: April 26, 2012Date of Patent: July 30, 2013Assignee: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Patent number: 8497076Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: GrantFiled: April 26, 2012Date of Patent: July 30, 2013Assignee: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Patent number: 8476008Abstract: Non-invasive methods are provided herein for the diagnosis of pre-diabetes and diabetes using biomarkers identified in a biological fluid, such as saliva. These biomarkers can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.Type: GrantFiled: July 23, 2009Date of Patent: July 2, 2013Assignee: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts, Vishnupriya Rao Paturi
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Publication number: 20120214179Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: ApplicationFiled: April 26, 2012Publication date: August 23, 2012Applicant: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Publication number: 20120208217Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: ApplicationFiled: April 26, 2012Publication date: August 16, 2012Applicant: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Publication number: 20120208218Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: ApplicationFiled: April 26, 2012Publication date: August 16, 2012Applicant: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Patent number: 8168396Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: GrantFiled: May 11, 2010Date of Patent: May 1, 2012Assignee: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Publication number: 20110218230Abstract: This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein that sNRF causes NP resistance. Based on these observations, methods of treating a cardiovascular disorder by inhibiting the activity of sNRF are disclosed. Assays are provided that use sNRF to screen agents for their ability to increase the biological activity of an NPR, for example agents that increase the sensitivity of NPR for NPs (such as atrial natriuretic peptide, ANP), or that decrease growth factor deleterious effects, or combinations thereof. Also provided are agents identified using the disclosed assays, and methods of using the agents, for example to treat or diagnose a cardiovascular disorder, such as heart failure.Type: ApplicationFiled: May 16, 2011Publication date: September 8, 2011Inventors: MICHAEL SILBERBACH, CHARLES T. ROBERTS, NATHAN AIRHART
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Publication number: 20110124022Abstract: Non-invasive methods are provided herein for the diagnosis of pre-diabetes and diabetes using biomarkers identified in a biological fluid, such as saliva. These biomarkers can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.Type: ApplicationFiled: July 23, 2009Publication date: May 26, 2011Applicant: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts, Vishnupriya Rao Paturi
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Patent number: 7943296Abstract: This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein that sNRF causes NP resistance. Based on these observations, methods of treating a cardiovascular disorder by inhibiting the activity of sNRF are disclosed. Assays are provided that use sNRF to screen agents for their ability to increase the biological activity of an NPR, for example agents that increase the sensitivity of NPR for NPs (such as atrial natriuretic peptide, ANP), or that decrease growth factor deleterious effects, or combinations thereof. Also provided are agents identified using the disclosed assays, and methods of using the agents, for example to treat or diagnose a cardiovascular disorder, such as heart failure.Type: GrantFiled: October 30, 2006Date of Patent: May 17, 2011Assignee: Oregon Health & Science UniversityInventors: Michael Silberbach, Charles T. Roberts, Nathan Airhart
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Publication number: 20100285498Abstract: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.Type: ApplicationFiled: May 11, 2010Publication date: November 11, 2010Applicant: DiabetOmics, LLCInventors: Srinivasa R. Nagalla, Charles T. Roberts
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Publication number: 20090312247Abstract: This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein that sNRF causes NP resistance. Based on these observations, methods of treating a cardiovascular disorder by inhibiting the activity of sNRF are disclosed. Assays are provided that use sNRF to screen agents for their ability to increase the biological activity of an NPR, for example agents that increase the sensitivity of NPR for NPs (such as atrial natriuretic peptide, ANP), or that decrease growth factor deleterious effects, or combinations thereof. Also provided are agents identified using the disclosed assays, and methods of using the agents, for example to treat or diagnose a cardiovascular disorder, such as heart failure.Type: ApplicationFiled: October 30, 2006Publication date: December 17, 2009Inventors: Michael Silberbach, Charles T. Roberts, Nathan Airhart
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Publication number: 20080206231Abstract: The present invention discloses for the first time that the insulin receptor (IR) is a target of Herstatin, which modulates IR and IR-mediated intracellular signaling. In preferred aspects, Herstatin binds at nM concentrations to cell-surface IR, up-regulates basal IR expression by several-fold, induces the accumulation of pro-IR, and stimulates insulin activation of the ERK pathway. Moreover, these changes in insulin signaling are accompanied by alterations in IGF-IR expression, IRS-2 levels, and the serine phosphorylation state of both IRS-1 and IRS-2.Type: ApplicationFiled: October 5, 2005Publication date: August 28, 2008Applicant: OREGON HEALTH AND SCIENCE UNIVERSITYInventors: Gail M. Clinton, Charles T. Roberts
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Patent number: 5988950Abstract: A system for preventing upward migration of contaminants in soil having capillary pores defined therein, the system comprising the soil and a hydrophobic substance applied to the soil, the substance being attracted to enter the capillary pores so that a barrier is formed which, under unsaturated soil conditions, prevents the upward migration of contaminants carried by water through the capillary pores in the soil.Type: GrantFiled: November 18, 1997Date of Patent: November 23, 1999Assignee: Atlantic Richfield CompanyInventors: Terry J. Moore, Charles T. Roberts
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Patent number: 5951204Abstract: A process for removing water-soluble contaminates from soil includes laying a mat over and in contact with the contaminated soil, applying water to the soil, permitting the water to be transferred from the soil to the mat, permitting the contaminants to be carried via the water into the mat, and permitting the water to be evaporated from the mat so that the contaminants precipitate in the mat.Type: GrantFiled: November 18, 1997Date of Patent: September 14, 1999Assignee: Atlantic Richfield CompanyInventors: Charles T. Roberts, Terry J. Moore
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Patent number: 5794698Abstract: A system and method for removing light non-aqueous liquids via a wellbore from at least a water-saturated subterranean zone using an oleophilic absorbent wick by positioning the wick in a wellbore extending from the surface through at least a portion of the subterranean water-saturated zone; reducing the pressure in the wellbore and removing vaporized light non-aqueous liquids from the wellbore.Type: GrantFiled: June 9, 1997Date of Patent: August 18, 1998Assignee: Atlantic Richfield CompanyInventor: Charles T. Roberts