Patents by Inventor Charles T. Tackney

Charles T. Tackney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION RELATED APPLICATIONS, ANALYSIS AND DIAGNOSIS
    Publication number: 20180031543
    Abstract: A solution is described for preserving cells and/or extra-cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.
    Type: Application
    Filed: February 9, 2016
    Publication date: February 1, 2018
    Inventors: Stephen ANDREWS, Youssef BIADILLAH, Manasi JAIN, David S. FRANK, John R. ZEMAN, Charles T. TACKNEY
  • Recombinant hybrid porin epitopes
    Patent number: 5547670
    Abstract: The present invention provides a polypeptide that is non-toxic in E. coli. The disclosed polypeptide comprises at least one antigenic sequence present in P.IA of N. gonorrhoeae and at least one antigenic sequence present in P.IB of N. gonorrhoeae. Further, the disclosed polypeptide of the invention is fused to a carrier peptide.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: August 20, 1996
    Assignee: Imclone Systems Incorporated
    Inventors: Neil I. Goldstein, Charles T. Tackney
  • Method of making cysteine depleted IL-6 muteins
    Patent number: 5545537
    Abstract: Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 13, 1996
    Assignee: The Trustees of Princeton University
    Inventors: Susan M. Skelly, Charles T. Tackney, John N. Snouwaert, Dana M. Fowlkes
  • Stabilized hepatitis B e antigen suitable for immunoassays
    Patent number: 5501948
    Abstract: Methods and materials for producing hepatitis virus HBe antigenic proteins useful in immunoassays without the necessity of maintaining these proteins in denaturing environments are disclosed. Assay methods and materials utilizing these HBe proteins are also provided.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: March 26, 1996
    Assignee: ImClone Systems Incorporated
    Inventors: Daniel J. Hicklin, Charles T. Tackney, Harlan W. Waksal
  • Cysteine depleted IL-6 muteins
    Patent number: 5359034
    Abstract: Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: October 25, 1994
    Assignees: Imclone Systems Inc., The University of North Carolina at Chapel Hill
    Inventors: Susan M. Skelly, Charles T. Tackney, John N. Snouwaert, Dana M. Fowlkes