Abstract: Systems and methods are disclosed for blood flow simulation. For example, a method may include performing a plurality of blood flow simulations using a first model of vascular blood flow, each of the plurality of blood flow simulations simulating blood flow in a vasculature of a patient or a geometry based on the vasculature of the patient; based on results of the plurality of blood flow simulations, generating a response surface mapping one or more first parameters of the first model to one or more second parameters of a reduced order model of vascular blood; determining values for the one or more parameters of the reduced order model mapped, by the response surface, from parameter values representing a modified state of the vasculature; and performing simulation using the reduced order model parameterized by the determined values, to determine a blood flow characteristic of the modified state of the vasculature.

Abstract: Various reconfigurable phononic devices, including phase shifters, mirrors, Mach Zehnder interferometers, memories, and transducers for use in both classical and quantum computing systems are disclosed. The individual phononic devices may be combined in various configurations to implement desired, more complex functionality. The phononic devices may be coupled together to implement the desired functionality using phononic waveguides. The phononic devices include one or more phase shifters that are operationally based on either hyperelasticity or a moving boundary effect.

Abstract: A computer-implemented method for processing electronic images to quantify coronary microvascular disease may include receiving imaging data of one or more captured electronic images. A first set of the imaging data may have been captured prior to an administration of one or more pharmacological agents, and a second set of the imaging data may have been captured subsequently. The method may further include providing the imaging data and a set of patient data to a machine-learning model. The machine-learning model may have been trained to identify coronary microvascular disease (CMD) features within the captured imaging data and the set of patient data and output one or more CMD measures and/or a predicted CMD endotype. The method may further include transmitting, to a user device, the one or more CMD measures and/or the predicted CMD endotype.

Abstract: Systems and methods are disclosed for assessing cardiovascular disease and treatment effectiveness based on adipose tissue. One method includes identifying a vascular bed of interest in a patient's vasculature; receiving a medical image of the patient's identified vascular bed of interest; identifying adipose tissue in the received medical image; receiving a geometric vascular model comprising a representation of the patient's identified vascular bed of interest; and computing an inflammation index associated with the geometric vascular model, using the identified adipose tissue.

Abstract: Systems and methods are disclosed for using patient specific anatomical models and physiological parameters to estimate perfusion of a target tissue to guide diagnosis or treatment of cardiovascular disease. One method includes receiving a patient-specific vessel model and a patent-specific tissue model of a patient anatomy; extracting one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, image characteristics, etc.) from the vessel or tissue models for one or more physiological states of the patient; estimating a characteristic of the perfusion of the patient-specific tissue model (e.g., via a trained machine learning algorithm) using the patient-specific physiological parameters; and outputting the estimated perfusion characteristic to a display.

Abstract: The present invention relates to methods and means for producing nitrogenase polypeptides in the mitochondria of plant cells. The present disclosure provides plant cells that express one or more MTP-Nif fusions and/or translational NifD-NifK and NifE-NifN fusions. The present disclosure also provides nucleic acid constructs encoding these fusions as well as expression constructs for expression and targeting of the fusions to the mitochondria of plant cells. The present disclosure also provides transgenic plants comprising the plant cells of the invention and products obtained therefrom.

Abstract: A fiber optic system includes a telecommunications chassis defining a front and a rear, a plurality of blades slidably mounted to the chassis, the blades slidable in a direction extending from the front to the rear, and a plurality of fiber optic cassettes removably mounted to each blade. Each fiber optic cassette includes a housing defining a maximum cassette height, the housing formed by a base and a cover mounted thereon. Each cassette defines fiber optic connection locations. The base of each cassette defines a notched area for receiving a portion of the blade on which the cassette is mounted such that the blade does not increase the overall maximum height defined by the housing.

Abstract: Methods, systems and apparatus, including computer programs encoded on computer storage media for fleet management of unmanned aerial vehicles, including flight authorization. One of the methods includes maintaining one or more rules associated with authorizing UAVs to implement flight plans. A request to generate a flight plan associated with a job is received, the request including information indicating a flight pattern comprising, at least, one or more waypoints associated with geospatial references. The flight plan is generated based on the request, and an initial authorization check is determined based on the maintained rules and the generated flight plan. Upon a positive determination, access to the generated flight plan is provided by a ground control system, and the flight plan is implemented.

Abstract: Content providers may wish to display different versions of content to different users, which may require different versions of the content to be deliverable. The assignment of a particular version of the content to a particular user may also need to persist over time for that particular user. It may be desirable that this functionality occurs at an edge server of a content delivery network, rather than at an origin server. In some embodiments, the edge server may receive a user request including a user identifier for content from a user device; identify an experiment key for the user request based at least in part on the user identifier, the experiment key associated with an experimental version of the content; and transmit an experiment fetch request including the experiment key to an edge cache to retrieve the experimental version of the content.

Abstract: Systems and methods are disclosed for use with a valve of a heart. An implant (100) includes a wing (120); a flexible frame (124); and a pair of anchor receivers (150). A pair of shafts (660) are transluminally advanced through a catheter (40), while the shafts are each engaged with a respective anchor receiver (150), to deploy the implant out of the catheter such that the wing extends away from the anchor receivers and over a first leaflet of the valve and toward an opposing leaflet of the valve, with a contact face (122) of the wing facing the first leaflet. A pair of drivers (70) secure the implant using a pair of anchors (30) to anchor each anchor receiver to tissue at respective sites of the heart. Other implementations are also described.

Abstract: Various reconfigurable phononic devices, including phase shifters, mirrors, Mach Zehnder interferometers, memories, and transducers for use in both classical and quantum computing systems are disclosed. The individual phononic devices may be combined in various configurations to implement desired, more complex functionality. The phononic devices may be coupled together to implement the desired functionality using phononic waveguides. The phononic devices include one or more phase shifters that are operationally based on either hyperelasticity or a moving boundary effect.

Abstract: A controller may receive sensor data from one or more sensor devices of the drilling machine. The sensor data indicates a vertical position of a drilling assembly of the drilling machine. The drilling assembly includes a drill string connected to a drill bit. The controller may determine, based on the sensor data, that the vertical position of the drilling assembly corresponds to a deck wrench engaging position. The controller may cause a deck wrench, of the drilling machine, to engage an engagement portion of the drill string based on determining that the vertical position of the drilling assembly corresponds to the deck wrench engaging position. The engagement portion of the drill string is adjacent to an end of the drill string connected to the drill bit.

Abstract: Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic.

Abstract: Systems and methods are disclosed for blood flow simulation. For example, a method may include performing a plurality of blood flow simulations using a first model of vascular blood flow, each of the plurality of blood flow simulations simulating blood flow in a vasculature of a patient or a geometry based on the vasculature of the patient; based on results of the plurality of blood flow simulations, generating a response surface mapping one or more first parameters of the first model to one or more second parameters of a reduced order model of vascular blood; determining values for the one or more parameters of the reduced order model mapped, by the response surface, from parameter values representing a modified state of the vasculature; and performing simulation using the reduced order model parameterized by the determined values, to determine a blood flow characteristic of the modified state of the vasculature.

Abstract: A digital signaling device provides visual, audible, and haptic indicators when the digital signaling device changes state. The digital signaling device has a same operational feel and response as a classic electro-mechanical decorator-style light switch, including maintaining switch paddle position, using attractive magnetic latching in combination with a spring contact. The switch paddle can be pressed into one of two positions, each position representing a different state of the digital signaling device. The switch paddle provides a visual indicator of the digital signaling device state in that the switch paddle is maintained in one of the two positions. The attractive magnetic latching provides both an audible and haptic indicator when the magnet pairs are engaged, which corresponds to a change of state of the digital signaling device. The spring contact provides a digital switching mechanism for changing the state of the digital signaling device.

Abstract: Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points.

Abstract: Provided herein is a composition including a compound having the structure: a pharmaceutically acceptable salt(s) thereof, and one or more excipients selected from (a)-(g): a) C2-6 alcohol; b) an organic solvent and/or a penetration enhancer; c) an antioxidant; d) a preservative; e) water; f) a pH adjuster; and g) a gelling agent, wherein C2-6 alcohol, the organic solvent and/or a penetration enhancer, the antioxidant, the preservative, water, the pH adjuster, and the gelling agent are defined and described herein. Methods of treating a skin disease, condition or disorder, in particular seborrheic keratosis, with the compositions are also provided herein.

Abstract: In an optical data transfer system, a beam modulator is configured to embed a set of data in an input beam. A multimode optical waveguide network has an in-coupling region for receiving the input beam. The multimode optical waveguide network is configured to guide the input beam to an out-coupling region of the multimode optical waveguide network. A spatial coherent detector is configured to measure a phase and an amplitude of an output optical field at multiple locations. The output optical field is at least partially defined by the input beam and thus exhibiting distortion effects caused by the passage of the beam through the multimode waveguide network. Signal processing is applied to an output of the spatial coherent detector, in order to compensate for the distortion effects, and thereby recover, from the output of the spatial coherent detector, the set of data embedded in the input beam.

Abstract: Provided herein are compositions comprising ruboxistaurin free base and its salts thereof and methods of use for treating conditions of the skin.

Abstract: Systems and methods are disclosed for assessing a risk of disease. One method includes obtaining an anatomic model associated with a target anatomy; modeling, using a processor, an injection of one or more virtual contrast agents into the anatomic model; performing a simulation of flow of blood and the one or more virtual contrast agents through the anatomic model; and computing one or more characteristics of concentration associated with the one or more virtual contrast agents at one or more locations in the anatomic model based on the simulation.