Patents by Inventor Charles Taylor

Charles Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190247124
    Abstract: Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Sethuraman SANKARAN, Leo Grady, Charles A. Taylor, Christopher K. Zarins
  • Publication number: 20190247123
    Abstract: Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Leo GRADY, Charles A. TAYLOR, Christopher K. ZARINS
  • Publication number: 20190247004
    Abstract: Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Charles A. Taylor, Leo Grady, Sethuraman Sankaran, Souma Sengupta, Hyun Jin Kim, Nan Xiao
  • Patent number: 10376317
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 13, 2019
    Assignee: HeartFlow, Inc.
    Inventor: Charles A. Taylor
  • Publication number: 20190233591
    Abstract: A process for the manufacturing of a poly(arylether sulfone) polymer comprising reacting in a solvent mixture comprising a polar aprotic solvent and in the presence of an alkali metal carbonate, a monomer mixture which contains: at least one 1,4:3,6-dianhydrohexitol selected from the group consisting of isosorbide (1), isomannide (2) and isoidide (3); at least one dihaloaryl compound of formula (S): X—Ar1—SO2—[Ar2—(T-Ar3)n—SO2]m—Ar4—X wherein n and m, equal to or different from each other, are independently zero or an integer of 1 to 5; X and X?, equal to or different from each other, are halogens selected from F, Cl, Br, I; each of Ar1, Ar2, Ar3 and Ar4 equal to or different from each other and at each occurrence, is an aromatic moiety, T is a bond or a divalent group optionally comprising one or more than one heteroatom; optionally, at least one dihydroxyl compound different from the diol (AA); optionally, at least one dihaloaryl compound different from the dihalo (BB); and optionally, at least one hydroxyl
    Type: Application
    Filed: April 4, 2019
    Publication date: August 1, 2019
    Applicant: SOLVAY SPECIALTY POLYMERS USA, LLC.
    Inventors: Narmandakh TAYLOR, Charles R. HOPPIN, Ahmed KHAN, Henry BRADLEY, Suresh R. SRIRAM
  • Patent number: 10358437
    Abstract: The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 23, 2019
    Assignees: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Brian K. Albrecht, Alexandre Cote, Terry Crawford, Martin Duplessis, Andrew Charles Good, Yves LeBlanc, Steven Magnuson, Christopher G. Nasveschuk, Richard Pastor, F. Anthony Romero, Alexander M. Taylor
  • Publication number: 20190217243
    Abstract: Systems and methods for removing elemental sulfur from a hydrocarbon fluid using an adsorbent.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 18, 2019
    Applicant: Bechtel Hydrocarbon Technology Solutions, Inc.
    Inventors: Martin A. Taylor, Charles L. Kimtantas
  • Patent number: 10354050
    Abstract: A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: July 16, 2019
    Assignee: THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Charles A. Taylor, Hyun Jin Kim, Jessica S. Coogan
  • Patent number: 10354759
    Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: July 16, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady
  • Patent number: 10354349
    Abstract: Systems and methods are disclosed for using geometry sensitivity information for guiding workflows in order to produce reliable models and quantities of interest. One method includes determining a geometric model associated with a target object; determining one or more quantities of interest; determining sensitivity information associated with one or more subdivisions of the geometric model and the one or more quantities of interest; and generating, using a processor, a workflow based on the sensitivity information.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: July 16, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor
  • Publication number: 20190200881
    Abstract: Systems and methods are disclosed for using patient specific anatomical models and physiological parameters to estimate perfusion of a target tissue to guide diagnosis or treatment of cardiovascular disease. One method includes receiving a patient-specific vessel model and a patent-specific tissue model of a patient anatomy; extracting one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, image characteristics, etc.) from the vessel or tissue models for one or more physiological states of the patient; estimating a characteristic of the perfusion of the patient-specific tissue model (e.g., via a trained machine learning algorithm) using the patient-specific physiological parameters; and outputting the estimated perfusion characteristic to a display.
    Type: Application
    Filed: March 4, 2019
    Publication date: July 4, 2019
    Inventors: Leo Grady, Michiel SCHAAP, Charles A. TAYLOR, Clara JAQUET
  • Patent number: 10339505
    Abstract: Provided is a method and a web-site integration system to integrate payment mechanisms into a commercial website that offers online merchants a flexible, user-friendly and customizable wizard to integrate payment mechanisms into their online commercial websites without having to understand the detailed intricacies of an API or other computer code. The wizard steps the merchant through creating an account to obtain credentials and educates the merchant on the page flows of the payment mechanism that the merchant wishes to integrate. Then, the wizard generates code snippets and files to be downloaded by the merchant and to be easily inserted into key pages of the merchant's online commercial website. The merchant can then test the completely integrated code in a developer's sandbox or go live with the completely integrated code.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: July 2, 2019
    Assignee: PAYPAL, INC.
    Inventors: Srinivasa Rao Pasupulati, Amish Patel, Nick Groleau, William Charles Taylor, Saleem Qadir
  • Patent number: 10327847
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: June 25, 2019
    Assignee: HeartFlow, Inc.
    Inventor: Charles A. Taylor
  • Publication number: 20190186207
    Abstract: A platform based drill includes a drilling platform including a frame structure with first and second opposite ends, and first and second opposite sides. A mast supported on a pivotal connection to the drilling platform adjacent the first end of the frame structure and including an upper portion extending above the pivotal connection, and a lower portion extending below the pivotal connection. An adjusting mechanism permits the mast to be pivotally adjusted to a negative drilling angle whereby the upper portion of the mast leans in a direction extending away from the second end and toward the first end.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 20, 2019
    Applicant: Caterpillar Global Mining Equipment LLC
    Inventors: Charles Taylor Hudson, Richard James LaReau, Gregory Scott
  • Patent number: 10321958
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: June 18, 2019
    Assignee: HeartFlow, Inc.
    Inventor: Charles A. Taylor
  • Patent number: 10316023
    Abstract: The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: June 11, 2019
    Assignees: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Brian K. Albrecht, Alexandre Cote, Terry Crawford, Martin Duplessis, Andrew Charles Good, Yves LeBlanc, Steven Magnuson, Christopher G. Nasveschuk, Richard Pastor, F. Anthony Romero, Alexander M. Taylor
  • Patent number: 10314655
    Abstract: Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: June 11, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Charles A. Taylor, Christopher K. Zarins
  • Patent number: 10314654
    Abstract: Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: June 11, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor, Christopher K. Zarins
  • Patent number: 10308614
    Abstract: The present invention relates to compounds of formula (I): and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: June 4, 2019
    Assignees: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Brian K. Albrecht, Alexandre Cote, Terry Crawford, Martin Duplessis, Andrew Charles Good, Yves LeBlanc, Steven R. Magnuson, Christopher G. Nasveschuk, F. Anthony Romero, Yong Tang, Alexander M. Taylor
  • Patent number: 10307131
    Abstract: Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 4, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Charles A. Taylor, Leo Grady, Sethuraman Sankaran, Souma Sengupta, Hyun Jin Kim, Nan Xiao