Abstract: Identifying indicia for use with a spiral notebook having a predetermined length and thickness. An elongated member includes a first elongated portion and a second elongated portion. A retaining member is provided at an end of the first elongated portion for securing and locking the elongated member relative to spiral turns of a spiral notebook. Identifying indicia may be positioned on an outer surface of the first elongated portion. The elongated member is adapted to be retained, secured and locked relative to the outer surface of the spiral turns of the spiral notebook by inserting the second elongated portion within the spiral turns of the spiral notebook and looping the first elongated portion to be disposed on an outer surface of the elongated spiral of the spiral notebook with the end of the second elongated portion being inserted within the retaining member.

Abstract: This disclosure includes sandwich composites comprising fiber-reinforced laminates. The disclosure further includes one or more film adhesives between a core and the fiber-reinforced laminates.

Abstract: The invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

Abstract: This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

Abstract: This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

Abstract: Peptidic molecules suitable for three dimensional NMR structure determination are provided which have been substituted with .sup.13 C and/or .sup.15 N in the backbone and/or at the .alpha.-carbon with .sup.2 H but not otherwise in the sidechains of the amino acid residues. One or more amino acids, amino acid species or substantially all of the amino acid residues of the molecule may be so substituted. A method of making the substituted peptidic molecules substituted in this manner is provided.