Patents by Inventor Charles V. Grudzinskas

Charles V. Grudzinskas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostacyclin analogs of the 1 series and related analogs wherein the carboxylic acid function has been replaced
    Patent number: 4235924
    Abstract: This disclosure describes certain 6,9.alpha.-epoxy prostacyclines and their intermediates. These compounds are useful as bronchodilators and inflammatory mediator release inhibitors.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: November 25, 1980
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Allan Wissner, Sow-Mei L. Chen
  • Novel vinyl-stannyl derivatives
    Patent number: 4233231
    Abstract: Vinylstannyl derivatives and the processes for their conversion to vinyliodides, vinylbromides and vinyllithium reagents. The vinylstannyl, vinyliodides, vinylbromide derivatives and vinyllithiums are useful as intermediates for the preparation of prostaglandin analogs.
    Type: Grant
    Filed: November 22, 1977
    Date of Patent: November 11, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Charles V. Grudzinskas, Sow-Mei L. Chen
  • 15-Deoxy-16-hydroxy-16-formyo or dimethoxy-methyl-prostane derivatives of the E and F series
    Patent number: 4230879
    Abstract: The invention disclosed herein relates to pharmacologically active prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and formyl or dimethoxymethyl as well as the pharmaceutically acceptable, non-toxic lower alkyl esters and salts thereof, and to the intermediates and processes for producing such compounds.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: October 28, 1980
    Assignee: American Cyanamid Company
    Inventors: Allen Wissner, Charles V. Grudzinskas
  • 15-Deoxy-16-hydroxy-16-fluoromethyl, difluoromethyl or trifluoromethyl prostaglandins of the E and F series
    Patent number: 4228298
    Abstract: The invention disclosed herein relates to pharmacologically active prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and fluoromethyl, difluoromethyl or trifluoromethyl as well as the pharmacologically acceptable, non-toxic lower alkyl esters and salts thereof, and to the intermediates and processes for producing such compounds.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: October 14, 1980
    Assignee: American Cyanamid Company
    Inventors: Sow-Mei L. Chen, Charles V. Grudzinskas
  • Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
    Patent number: 4228296
    Abstract: This disclosure describes novel 16-aryloxy-17,18, 19,20-tetranorprostanoic acids and derivatives thereof useful as bronchodilators and as hypotensive and contraceptive agents.
    Type: Grant
    Filed: January 24, 1979
    Date of Patent: October 14, 1980
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Martin J. Weiss
  • 15-Deoxy-16-hydroxy-16-chloromethyl or bromomethyl prostaglandins of the E and F series
    Patent number: 4227011
    Abstract: The invention disclosed herein relates to pharmacologically active prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and chloromethyl or bromomethyl as well as the pharmacologically acceptable, nontoxic lower alkyl esters and salts thereof, and to the intermediates and processes for producing such compounds.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: October 7, 1980
    Assignee: American Cyanamid Company
    Inventors: Sow-Mei L. Chen, Charles V. Grudzinskas
  • Novel 11-deoxy-substituted prostaglandins of the E and F series
    Patent number: 4219496
    Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.
    Type: Grant
    Filed: March 10, 1978
    Date of Patent: August 26, 1980
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Martin J. Weiss
  • Novel 11-deoxy-11-substituted prostaglandins of the E and F series
    Patent number: 4218565
    Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.
    Type: Grant
    Filed: March 10, 1977
    Date of Patent: August 19, 1980
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Martin J. Weiss
  • 15-Deoxy-16-hydroxy-16-vinyl or cyclopropyl prostan-1-ols of the E, A and F series
    Patent number: 4206151
    Abstract: This disclosure describes novel 15-deoxy-16 hydroxy-16-substituted prostanoic acid analogs in which the C-1 carboxyl is replaced by a primary alcohol and carboxylic acid esters, carbonates and carbomates thereof. The prostanoic carbinols and carboxylic acid esters thereof described herein have utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: December 21, 1978
    Date of Patent: June 3, 1980
    Assignee: American Cyanamid Company
    Inventor: Charles V. Grudzinskas
  • 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
    Patent number: 4202989
    Abstract: This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: May 13, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
    Patent number: 4198521
    Abstract: This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators, as hypotensive agents and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: April 15, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
    Patent number: 4192950
    Abstract: This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: September 22, 1977
    Date of Patent: March 11, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • Various- 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
    Patent number: 4191699
    Abstract: 15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: March 4, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
    Patent number: 4190596
    Abstract: 15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: February 26, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-mei L. Chen
  • Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
    Patent number: 4190597
    Abstract: 15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: February 26, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-mei L. Chen
  • Novel 11-deoxy-11-substituted prostaglandins of the E and F series
    Patent number: 4141914
    Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.
    Type: Grant
    Filed: July 24, 1972
    Date of Patent: February 27, 1979
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Martin J. Weiss