Abstract: The disclosure relates to a flow-deflecting medical device comprising a support structure and two flow-deflecting members attached to the support structure. The first flow-deflecting member is movable to a position in which it contacts and substantially seals against the second flow-deflecting member.

Abstract: Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel.

Abstract: A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.

Abstract: A flow-deflecting medical device comprising a support structure and at least one flow-deflecting member attached to the support structure. The flow-deflecting member is at least partially evertible between a first position and a second position. In the first position, antegrade flow contacts the antegrade surface of the flow-deflecting member, urging the flow-deflecting member proximally in the body vessel, such that antegrade flow is substantially uninterrupted. In the second position, retrograde flow contacts the retrograde surface of the flow-deflecting member, urging the flow-deflecting member distally in the body vessel, such that retrograde flow is received and redirected by the flow-deflecting member. Also provided is a method for treating a body vessel valve-related condition comprising implanting a flow-deflecting medical device proximal to a native valve.

Abstract: Prosthetic valves, methods of making medical devices, and methods of treatment are provided. The prosthetic valves of the invention have a valve portion moveable between first and second positions, and a spacing member that has a thickness and protects a portion of the valve portion from contact with a wall of a vessel in which the prosthetic valve is implanted, and/or another structural component of the prosthetic valve, such as a support frame.

Abstract: Delivery systems for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. The delivery systems comprise a sheath member and an inner member slideably disposed within a cavity formed by the sheath member. An expandable intraluminal medical device is disposed about the inner member and is initially positioned within the delivery system. A means for preventing axial movement of the inner member holds the inner member in position so that, while the delivery system and medical device are positioned at a desired point of treatment, the sheath member can be retracted while an axial position of the inner member is substantially maintained.

Abstract: Medical devices for implantation within a body vessel can include a remodelable material, such as an extracellular matrix material, positioned within a lumen defined by an outer covering material. The covering material is preferably substantially non-remodelable, and can be supported by a radially expandable frame. The medical device can also include a valve means positioned within the covering material. The valve means can include one or more valve leaflets formed from the remodelable material, and a separate valve support frame. One or more therapeutic agents can be associated with the remodelable material or the covering material.

Abstract: Disclosed is an anchoring element for an implantable prosthesis that includes a barb, wherein the anchoring element, which includes a basal portion, comprises a thin layer of material, such as a cannula or sheet of metal, that extends or wraps at least partially around the strut of the prosthesis to which it is attached. The barb is configured to extend outward from the basal portion to penetrate adjacent tissue. The anchoring element is either permanently affixed to the strut, such as by laser or spot welding, crimping, or some other method of bonding, or allowed to slide longitudinally over the strut between two points or stops in order to relieve any excessive loads placed upon the barb that could cause fracture. The anchoring element and strut may be configured to limit axial rotation of the barb, while still allowing longitudinal movement. In another embodiment, the slidable anchoring element may be manipulated following initial deployment to reorient the barb toward the implantation site.

Abstract: Prosthetic valves, methods of making medical devices, and methods of treatment are provided. The prosthetic valves of the invention have a valve portion moveable between first and second positions, and a spacing member that has a thickness and protects a portion of the valve portion from contact with a wall of a vessel in which the prosthetic valve is implanted, and/or another structural component of the prosthetic valve, such as a support frame.

Abstract: Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel.

Abstract: A medical system for performing a tissue biopsy at a remote location within a patient is disclosed. The medical system comprises an elongate outer cutting member, an elongate inner member movably disposed within the outer member, and a tissue traction member for anchoring bodily tissue and pulling a sample of the tissue within the outer cutting member.

Abstract: A drainage catheter includes an elongated tubular member, a locking assembly engaged with a proximal end of the tubular member, and a tension member for drawing a distal end of the tubular member into a desired configuration. The locking assembly includes a connector, a locking arm, and a locking mechanism. The connector has an exterior surface profile that corresponds with an interior surface profile of the locking arm. The locking arm is pivotably attached to the connector to enable pivoting movement of the locking arm between an unlocked position and a locked position whereby the tension member is secured between the locking arm and the connector when the arm is in the locked position. The locking assembly may alternatively comprise a connector and a sliding sleeve or a connector having a clamping element disposed therein.

Abstract: A method of occluding a fistula in a patient is provided. The method includes inserting a placement member having a coupling structure, such as a wire guide having a loop at one end, through the primary opening of a fistula and at least partially into the fistula tract; connecting the coupling structure to a medical device, such as a plug, graft, or other occluding member; and inserting the medical device into the fistula by pulling the placement member through the fistula until the medical device contacts the interior wall of the fistula. Medical devices and systems for occluding fistulas are also provided.

Abstract: Described are percutaneous vascular valves (11) free of attached support structures and deployment systems (31) and methods for providing attachment of the valves within a vascular vessel.

Abstract: A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.

Abstract: Medical device delivery systems that include a distal protection feature are provided. A distal tip member that includes a distal protection device and a mounting region for a self-expandable, intraluminal medical device is slidably disposed within a passageway defined by a tubular member.

Abstract: Methods of reducing retrograde fluid flow through a valve within a body vessel are provided. The methods can include the steps of identifying a valve exhibiting an undesirable amount of retrograde fluid flow within a body vessel, such as a venous valve or a heart valve, and providing a means for reducing the retrograde fluid flow. A medical device providing a desired amount of retrograde fluid flow can be modified after permitting the medical device to remain in a body cavity for a remodeling-effective time period. The implanted medical device can be modified by subsequently reducing the amount of retrograde fluid flow permitted across the implanted prosthetic valve within the body vessel.

Abstract: Medical device delivery systems that include a distal protection feature are provided. A distal tip member that includes a distal protection device and a mounting region for a self-expandable, intraluminal medical device is slidably disposed within a passageway defined by a tubular member.

Abstract: Prosthetic valve devices, as well as systems and methods for the delivery thereof, are disclosed. A device includes one or more leaflets disposed within a frameless conduit, wherein the conduit is adapted for attachment to walls of a vascular vessel, and the leaflets are adapted for attachment to walls of the conduit. The leaflets are configured to selectively restrict blood flow through the conduit, and the conduit can include wall-engaging adaptations, for example, barbs or an adhesive. The conduit and the leaflets are formed with a flexible material, which may comprise a remodelable material and/or a synthetic polymer.

Abstract: Medical devices that provide valves for regulating fluid flow through a body vessel are provided. The valves include a support frame having one or more adaptations for forming a leak path between the support frame and an interior wall of a body vessel in which the valve is implanted. A controlled amount of retrograde flow is able to flow through the leak path when the valve is implanted in a body vessel.