Patents by Inventor Charles W. Emala

Charles W. Emala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
    Publication number: 20230103216
    Abstract: Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Application
    Filed: August 11, 2022
    Publication date: March 30, 2023
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
    Patent number: 11447495
    Abstract: Substituted benzo[f]imidazo[1,5-?][1,4]diazepines of formula (I?) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: September 20, 2022
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
    Publication number: 20210284649
    Abstract: Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Application
    Filed: August 16, 2017
    Publication date: September 16, 2021
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
    Patent number: 9879020
    Abstract: Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: January 30, 2018
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Douglas C. Stafford, James M. Cook, Alexander E. Arnold, Charles W. Emala, George Gallos, Michael Rajesh Stephen
  • NOVEL GABAA AGONISTS AND METHODS OF USING TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
    Publication number: 20150232473
    Abstract: Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.
    Type: Application
    Filed: September 20, 2013
    Publication date: August 20, 2015
    Inventors: Douglas C. Stafford, James M. Cook, Alexander E. Arnold, Charles W. Emala, George Gallos, Michael Rajesh Stephen
  • Method of mediating Airway Smooth Muscle Construction Due to Airway Irritation
    Publication number: 20100048732
    Abstract: Methods of minimizing bronchospasm and contraction of airway smooth muscle due to irritation of the airway are provided. More particularly, a method is provided of mitigating bronchospasm or airway smooth muscle constriction due to irritation. This method includes administering to a subject in need of such treatment an amount of propofol or a derivative thereof effective to decrease the severity and/or duration of bronchospasm or airway smooth muscle constriction. Also provided are methods of up-regulating GABA mediated relaxation of airway smooth muscle at GABAA receptors expressed on airway smooth muscle and methods of anesthetizing a subject and minimizing bronchospasm or airway smooth muscle constriction due to irritation using propofol or a propofol derivative.
    Type: Application
    Filed: May 30, 2007
    Publication date: February 25, 2010
    Inventor: Charles W. Emala, SR.