Patents by Inventor Charles W. Heilig

Charles W. Heilig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mesangial cell lines as models for the study and treatment of diabetic tissue complications
    Patent number: 5939275
    Abstract: An isolated and stable clone of mesangial cells which exhibit characteristics of diabetic cells when grown in normal glucose medium. The cells demonstrate an increase in glucose transport over normal mesangial cells and that provides a model for simulating diabetes in mesangial cells. Further, a stable, permanent clone of mesangial cells which underexpress GLUT1 mRNA and protein and which can be used therapeutically has been isolated.
    Type: Grant
    Filed: September 1, 1995
    Date of Patent: August 17, 1999
    Inventors: Charles W. Heilig, Svend O. Freytag, Bruce L. Riser
  • Treatment of osmotic disturbance with organic osmolytes
    Patent number: 5182299
    Abstract: A method of treating an osmotic disturbance in an animal which comprises administering to an animal an effective amount of an organic osmolyte, wherein the organic osmolyte is a polyol. Specific polyols include myo-inositol and sorbitol. Also included are precursors of organic osmolytes including precursors of polyols. Other polyol precursors are selected from the group consisting of glucose, glucose polymers, and glycerol. Also incluThis invention was funded by a research grant from the National Institutes of Health, 1RO1 DK36031, which provides to the United States Government certain rights in the invention.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: January 26, 1993
    Assignee: Brigham and Women's Hospital
    Inventors: Steven R. Gullans, Charles W. Heilig